Search Results - "Mighton, Chloe"

Clinical and psychological outcomes of receiving a variant of uncertain significance from multigene panel testing or genomic sequencing: a systematic review and meta-analysis by Mighton, Chloe, Shickh, Salma, Uleryk, Elizabeth, Pechlivanoglou, Petros, Bombard, Yvonne

“…This study systematically reviewed and synthesized the literature on psychological and clinical outcomes of receiving a variant of uncertain significance (VUS)…”
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The clinical utility of exome and genome sequencing across clinical indications: a systematic review by Shickh, Salma, Mighton, Chloe, Uleryk, Elizabeth, Pechlivanoglou, Petros, Bombard, Yvonne

“…Exome sequencing and genome sequencing have the potential to improve clinical utility for patients undergoing genetic investigations. However, evidence of…”
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Heath policy guiding the identification, analysis and management of secondary findings for individuals undergoing genomic sequencing: a systematic review protocol by Majeed, Safa, Mighton, Chloe, Malkin, David, Bombard, Yvonne

“…Genomic sequencing is increasingly enabling precision care across medical specialties; however, the discovery of genomic 'secondary findings' (SFs) unrelated…”
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Effect of genetics clinical decision support tools on health-care providers’ decision making: a mixed-methods systematic review by Sebastian, Agnes, Carroll, June C., Oldfield, Leslie E., Mighton, Chloe, Shickh, Salma, Uleryk, Elizabeth, Bombard, Yvonne

“…Patient care involving genetics is challenging for nongenetics health-care providers. Clinical decision support (CDS) tools are a potential solution because…”
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Variant classification changes over time in BRCA1 and BRCA2 by Mighton, Chloe, Charames, George S., Wang, Marina, Zakoor, Kathleen-Rose, Wong, Andrew, Shickh, Salma, Watkins, Nicholas, Lebo, Matthew S., Bombard, Yvonne, Lerner-Ellis, Jordan

“…Purpose To report BRCA1 and BRCA2 ( BRCA1/2 ) variant reassessments and reclassifications between 2012 and 2017 at the Advanced Molecular Diagnostics…”
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From the patient to the population: Use of genomics for population screening by Mighton, Chloe, Shickh, Salma, Aguda, Vernie, Krishnapillai, Suvetha, Adi-Wauran, Ella, Bombard, Yvonne

“…Genomic medicine is expanding from a focus on diagnosis at the patient level to prevention at the population level given the ongoing under-ascertainment of…”
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Widening the lens of actionability: A qualitative study of primary care providers' views and experiences of managing secondary genomic findings by Sebastian, Agnes, Carroll, June C, Vanstone, Meredith, Clausen, Marc, Kodida, Rita, Reble, Emma, Mighton, Chloe, Shickh, Salma, Aronson, Melyssa, Eisen, Andrea, Elser, Christine, Lerner-Ellis, Jordan, Kim, Raymond H, Bombard, Yvonne

“…Most secondary genomic findings (SFs) fall in the scope of primary care practice. However, primary care providers' (PCPs) capacity to manage these findings is…”
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Beyond medically actionable results: an analytical pipeline for decreasing the burden of returning all clinically significant secondary findings by Reble, Emma, Gutierrez Salazar, Mariana, Zakoor, Kathleen-Rose, Khalouei, Sam, Clausen, Marc, Kodida, Rita, Shickh, Salma, Mighton, Chloe, Cohn, Iris, Schrader, Kasmintan A., Kim, Raymond H., Lerner-Ellis, Jordan, Bombard, Yvonne

“…Genomic sequencing advances have increased the potential to identify secondary findings (SFs). Current guidelines recommend the analysis of 59 medically…”
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Multigene panel testing for hereditary breast and ovarian cancer in the province of Ontario by Lerner-Ellis, Jordan, Mighton, Chloe, Lazaro, Conxi, Watkins, Nicholas, Di Gioacchino, Vanessa, Wong, Andrew, Chang, Martin C., Charames, George S.

“…Purpose The aim of this study was to determine the diagnostic yield of multigene panel testing among patients referred with hereditary breast and ovarian…”
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Effectiveness of the Genomics ADvISER decision aid for the selection of secondary findings from genomic sequencing: a randomized clinical trial by Bombard, Yvonne, Clausen, Marc, Shickh, Salma, Mighton, Chloe, Casalino, Selina, Kim, Theresa H.M., Muir, Sarah M., Carlsson, Lindsay, Baxter, Nancy, Scheer, Adena, Elser, Christine, Eisen, Andrea, Panchal, Seema, Graham, Tracy, Aronson, Melyssa, Piccinin, Carolyn, Mancuso, Talia, Semotiuk, Kara, Evans, Michael, Carroll, June C., Offit, Kenneth, Robson, Mark, Hamilton, Jada G., Glogowski, Emily, Schrader, Kasmintan, Kim, Raymond H., Lerner-Ellis, Jordan, Thorpe, Kevin E., Laupacis, Andreas, Bombard, Yvonne, Armel, Susan, Aronson, Melyssa, Bayoumi, Ahmed, Bond, Ken, Caulfield, Timothy, Clausen, Marc, Clifford, Tammy, Cohn, Iris, Dhalla, Irfan, Earle, Craig C., Elser, Christine, Isaranuwatchai, Wanrudee, Kastner, Monika, Kim, Raymond H., Mujoomdar, Michelle, Robson, Mark E., Scheer, Adena, Scherer, Stephen W., Schrader, Kasmintan, Sullivan, Terrence, Thorpe, Kevin E.

“…To evaluate the effectiveness of the Genomics ADvISER (www.genomicsadviser.com) decision aid (DA) for selection of secondary findings (SF), compared with…”
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Patient and public preferences for being recontacted with updated genomic results: a mixed methods study by Mighton, Chloe, Clausen, Marc, Sebastian, Agnes, Muir, Sarah M., Shickh, Salma, Baxter, Nancy N., Scheer, Adena, Glogowski, Emily, Schrader, Kasmintan A., Thorpe, Kevin E., Kim, Theresa H. M., Lerner-Ellis, Jordan, Kim, Raymond H., Regier, Dean A., Bayoumi, Ahmed M., Bombard, Yvonne

“…Variants of uncertain significance (VUS) are frequently reclassified but recontacting patients with updated results poses significant resource challenges. We…”
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Correction to: Multigene panel testing for hereditary breast and ovarian cancer in the province of Ontario by Lerner-Ellis, Jordan, Mighton, Chloe, Lazaro, Conxi, Watkins, Nicholas, Di Gioacchino, Vanessa, Wong, Andrew, Chang, Martin C., Charames, George S.

“…In the original article published, the proportions for the categories "Non-AJ, non-FC, non-Hispanic White" and "Other ethnicity" have incorrectly been…”
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The role of digital tools in the delivery of genomic medicine: enhancing patient-centered care by Shickh, Salma, Rafferty, Sara A., Clausen, Marc, Kodida, Rita, Mighton, Chloe, Panchal, Seema, Lorentz, Justin, Ward, Thomas, Watkins, Nicholas, Elser, Christine, Eisen, Andrea, Carroll, June C., Glogowski, Emily, Schrader, Kasmintan A., Lerner-Ellis, Jordan, Kim, Raymond H., Chitayat, David, Shuman, Cheryl, Bombard, Yvonne, Bombard, Yvonne, Armel, Susan, Aronson, Melyssa, Baxter, Nancy, Bond, Kenneth, Capo-Chichi, José-Mario, Caulfield, Timothy, Clifford, Tammy, Cohn, Iris, Dhalla, Irfan, Earle, Craig C., Evans, Mike, Graham, Tracy, Hamilton, Jada G., Isaranuwatchai, Wanrudee, Kastner, Monika, Laupacis, Andreas, Morel, Chantal F., Mujoomdar, Michelle, Offit, Kenneth, Robson, Mark E., Scheer, Adena, Scherer, Stephen W., Sullivan, Terrence, Thorpe, Kevin E.

“…Alternative models of genetic counseling are needed to meet the rising demand for genomic sequencing. Digital tools have been proposed as a method to augment…”
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Primary care provider perspectives on using genomic sequencing in the care of healthy children by Joshi, Esha, Mighton, Chloe, Clausen, Marc, Casalino, Selina, Kim, Theresa H M, Kowal, Christine, Birken, Catherine, Maguire, Jonathon L, Bombard, Yvonne

“…Genome sequencing (GS) studies involving healthy children can advance scientific knowledge of genetic variation. Little research has examined primary care…”
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Quality of life drives patients' preferences for secondary findings from genomic sequencing by Mighton, Chloe, Carlsson, Lindsay, Clausen, Marc, Casalino, Selina, Shickh, Salma, McCuaig, Laura, Joshi, Esha, Panchal, Seema, Semotiuk, Kara, Ott, Karen, Elser, Christine, Eisen, Andrea, Kim, Raymond H, Lerner-Ellis, Jordan, Carroll, June C, Glogowski, Emily, Schrader, Kasmintan, Bombard, Yvonne

“…There is growing impetus to include measures of personal utility, the nonmedical value of information, in addition to clinical utility in health technology…”
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Development of patient "profiles" to tailor counseling for incidental genomic sequencing results by Mighton, Chloe, Carlsson, Lindsay, Clausen, Marc, Casalino, Selina, Shickh, Salma, McCuaig, Laura, Joshi, Esha, Panchal, Seema, Graham, Tracy, Aronson, Melyssa, Piccinin, Carolyn, Winter-Paquette, Laura, Semotiuk, Kara, Lorentz, Justin, Mancuso, Talia, Ott, Karen, Silberman, Yael, Elser, Christine, Eisen, Andrea, Kim, Raymond H, Lerner-Ellis, Jordan, Carroll, June C, Glogowski, Emily, Schrader, Kasmintan, Bombard, Yvonne

“…Guidelines recommend that providers engage patients in shared decision-making about receiving incidental results (IR) prior to genomic sequencing (GS), but…”
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P782: Validation of low-pass genome sequencing for prenatal diagnosis by Mighton, Chloe, Noor, Abdul, Watkins, Nicholas, Di Gioacchino, Vanessa, Lerner-Ellis, Jordan, Wong, Andrew, Anggala, Nina, Chitayat, David, Greenfeld, Elena

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P539: International policies guiding the identification, analysis, and management of secondary findings from genomic sequencing: Results from a systematic review by Majeed, Safa, Johnston, Christine, Saeedi, Saumeh, Mighton, Chloe, Rokoszak, Vanessa, Abbasi, Ilham, Grewal, Sonya, Aguda, Vernie, Malkin, David, Bombard, Yvonne

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Genetics Adviser: a protocol for a mixed-methods randomised controlled trial evaluating a digital platform for genetics service delivery by Shickh, Salma, Hirjikaka, Daena, Clausen, Marc, Kodida, Rita, Mighton, Chloe, Reble, Emma, Sam, Jordan, Panchal, Seema, Aronson, Melyssa, Graham, Tracy, Armel, Susan Randall, Glogowski, Emily, Elser, Christine, Eisen, Andrea, Carroll, June C, Shuman, Cheryl, Seto, Emily, Baxter, Nancy N, Scheer, Adena, Shastri-Estrada, Serena, Feldman, Geoff, Thorpe, Kevin E, Schrader, Kasmintan A, Lerner-Ellis, Jordan, Kim, Raymond H, Faghfoury, Hanna, Bombard, Yvonne

“…IntroductionThe high demand for genetic tests and limited supply of genetics professionals has created a need for alternative service delivery models. Digital…”
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P397: Clinical utility of all types of medically relevant secondary findings: A systematic evidence review by Mighton, Chloe, Rokoszak, Vanessa, Dhaliwal, Simran, Majeed, Safa, Aguda, Vernie, Grewal, Sonya, Sebastian, Agnes, Shickh, Salma, Lightfoot, David, Bombard, Yvonne

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