Search Results - "Mifsud, N. A."

Linking CMV Serostatus to Episodes of CMV Reactivation Following Lung Transplantation by Measuring CMV‐Specific CD8+ T‐Cell Immunity by Westall, G. P., Mifsud, N. A., Kotsimbos, T.

“…CMV‐specific immunity was assessed in a longitudinal cohort of 39 lung transplant recipients (LTR) who were followed prospectively from the time of transplant…”
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Clara Cells and Injury Post Lung Transplantation: An Evolving Story by Bourdin, A., Mifsud, N. A., Chanez, B., Chanez, P., Snell, G., Kotsimbos, T. C.

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Human leucocyte antigen‐defined microchimerism early post‐transplant does not predict for stable lung allograft function by Rowntree, L. C., Bayliss, J., Nguyen, T. H. O., Kotsimbos, T. C., Mifsud, N. A.

“…Summary Microchimerism is the presence of foreign cells in an individual below 1% of total cells, which can occur in the setting of solid organ…”
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Immunodominance Hierarchies and Gender Bias in Direct TCD8‐Cell Alloreactivity by Mifsud, N. A., Purcell, A. W., Chen, W., Holdsworth, R., Tait, B. D., McCluskey, J.

“…Allogeneic solid organ transplantation often occurs across multiple donor–recipient HLA mismatches with consequent risk of allograft rejection. However, there…”
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Endogenous-peptide-dependent alloreactivity: new scientific insights and clinical implications by D'Orsogna, L. J., Nguyen, T. H. O., Claas, F. H. J., Witt, C., Mifsud, N. A.

“…T‐cell alloreactivity is generated via immune responsiveness directed against allogeneic (allo) human leucocyte antigen (HLA) molecules. Whilst the…”
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Use of the Polymerase Chain Reaction–Sequence Specific Oligonucleotide Technique for the Detection of the K1/K2 Polymorphism of the Kell Blood Group System by Mifsud, N.A., Haddad, A.P., Sparrow, R.L., Condon, J.A.

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A novel cis‐AB variant allele arising from a nucleotide substitution A796C in the B transferase gene by Mifsud, Nicole A., Watt, Julie M., Condon, Jenny A., Haddad, Albert P., Sparrow, Rosemary L.

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Expression of Surfactant Protein mRNA in Normal and Neoplastic Lung of B6C3F1 Mice as Demonstrated by In Situ Hybridization by Pilling, A. M., Mifsud, N. A. M., Jones, S. A., Endersby-Wood, H. J., Turton, J. A.

“…The localization of surfactant protein (SP), A, B, C, and D mRNAs was examined in B6C3F1 mice in the normal lung, and in a range of spontaneous proliferative…”
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Cross-Reactive CMV-Specific T Cells Significantly Increase in Frequency and TCR Clonality in the Setting of Viral Reactivation in Human Lung Transplantation: 940 by Mifsud, N. A., Nguyen, T. H.O., Kedzierska, K., Bird, N., Westall, G. P., Kotsimbos, T. C.

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Humanleucocyte antigen-defined microchimerism early post-transplant does not predict for stable lung allograft function by Rowntree, L C, Bayliss, J, Nguyen, T H O, Kotsimbos, T C, Mifsud, N A

“…Summary Microchimerism is the presence of foreign cells in an individual below 1% of total cells, which can occur in the setting of solid organ…”
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Quantitative and Functional Diversity of Cross-Reactive EBV-Specific CD8+ T Cells in a Longitudinal Study Cohort of Lung Transplant Recipients by MIFSUD, Nicole A, NGUYEN, Thi Hoang Oanh, TAIT, Brian D, KOTSIMBOS, Tom C

“…Cross-reactive antiviral memory T cells constitute a significant proportion of the alloresponse, potentially playing a pivotal role in adverse posttransplant…”
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Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3 by Kjer-Nielsen, Lars, Dunstone, Michelle A, Kostenko, Lyudmila, Ely, Lauren K, Beddoe, Travis, Mifsud, Nicole A, Purcell, Anthony W, Brooks, Andrew G, McCluskey, James, Rossjohn, Jamie

“…The CD3 epsilon gamma heterodimer is essential for expression and function of the T cell receptor. The crystal structure of the human CD3 epsilon gamma…”
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Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion by Zernich, Danielle, Purcell, Anthony W, Macdonald, Whitney A, Kjer-Nielsen, Lars, Ely, Lauren K, Laham, Nihay, Crockford, Tanya, Mifsud, Nicole A, Bharadwaj, Mandvi, Chang, Linus, Tait, Brian D, Holdsworth, Rhonda, Brooks, Andrew G, Bottomley, Stephen P, Beddoe, Travis, Peh, Chen Au, Rossjohn, Jamie, McCluskey, James

“…HLA class I polymorphism creates diversity in epitope specificity and T cell repertoire. We show that HLA polymorphism also controls the choice of Ag…”
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High Levels of Mannose-Binding Lectin Are Associated With Poor Outcomes After Lung Transplantation by CARROLL, Katherine E, DEAN, Melinda M, HEATLEY, Susan L, MEEHAN, Aislin C, MIFSUD, Nicole A, KOTSIMBOS, Tom C, SNELL, Greg I, WESTALL, Glen P

“…Mannose-binding lectin (MBL) is a key molecule of the innate immune system and, in addition to the classical and alternative pathways, a principle driver of…”
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A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition by Macdonald, Whitney A, Purcell, Anthony W, Mifsud, Nicole A, Ely, Lauren K, Williams, David S, Chang, Linus, Gorman, Jeffrey J, Clements, Craig S, Kjer-Nielsen, Lars, Koelle, David M, Burrows, Scott R, Tait, Brian D, Holdsworth, Rhonda, Brooks, Andrew G, Lovrecz, George O, Lu, Louis, Rossjohn, Jamie, McCluskey, James

“…HLA-B*4402 and B*4403 are naturally occurring MHC class I alleles that are both found at a high frequency in all human populations, and yet they only differ by…”
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Natural Killer Cell Activation in the Lung Allograft Early Posttransplantation by MEEHAN, Aislin C, SULLIVAN, Lucy C, MIFSUD, Nicole A, BROOKS, Andrew G, SNELL, Greg I, KOTSIMBOS, Tom C, WESTALL, Glen P

“…In addition to their known antiviral and host defense functions, emerging evidence suggests that natural killer (NK) cells may influence allograft outcomes…”
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Immunodominance hierarchies and gender bias in direct T(CD8)-cell alloreactivity by Mifsud, N A, Purcell, A W, Chen, W, Holdsworth, R, Tait, B D, McCluskey, J

“…Allogeneic solid organ transplantation often occurs across multiple donor-recipient HLA mismatches with consequent risk of allograft rejection. However, there…”
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Immunodominant CD4+Responses Identified in a Patient Vaccinated with Full-Length NY-ESO-1 Formulated with ISCOMATRIX Adjuvant by Chen, Qiyuan, Jackson, Heather, Parente, Phillip, Luke, Tina, Rizkalla, Mark, Tai, Tsin Yee, Zhu, He-Cheng, Mifsud, Nicole A., Dimopoulos, Nektaria, Masterman, Kelly-Anne, Hopkins, Wendie, Goldie, Heather, Maraskovsky, Eugene, Green, Simon, Miloradovic, Lena, McCluskey, James, Old, Lloyd J., Davis, Ian D., Cebon, Jonathan, Chen, Weisan

“…There is increasing evidence showing the involvement of CD4+T cells in initiating and maintaining antitumor immune responses. NY-ESO-1 is expressed by various…”
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Differential dynamics of donor DC and non-DC peripheral blood mononuclear cell microchimerism in lung transplantation by Van der Meulen, Joel, Mifsud, Nicole A, Abud, Diahnn, Paul, Eldho, Varney, Michael D, Lewin, Sharon R, Cameron, Paul U, Kotsimbos, Tom C

“…Abstract Donor cell microchimerism induces tolerance in animal models and may increase graft survival in man. Since dendritic cells (DC) are critical for…”
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Dissecting the role of peptides in the immune response: theory, practice and the application to vaccine design by Purcell, Anthony W., Zeng, Weiguang, Mifsud, Nicole A., Ely, Lauren K., Macdonald, Whitney A., Jackson, David C.

“…Analytical biochemistry and synthetic peptide based chemistry have helped to reveal the pivotal role that peptides play in determining the specificity,…”
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