Search Results - "Mietzner, A"

Rational Design of Engineered Cationic Antimicrobial Peptides Consisting Exclusively of Arginine and Tryptophan, and Their Activity against Multidrug-Resistant Pathogens by DESLOUCHES, Berthony, STECKBECK, Jonathan D, CRAIGO, Jodi K, DOI, Yohei, MIETZNER, Timothy A, MONTELARO, Ronald C

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Lipocalin 2 Is Required for Pulmonary Host Defense against Klebsiella Infection by Chan, Yvonne R, Liu, Jessica S, Pociask, Derek A, Zheng, Mingquan, Mietzner, Timothy A, Berger, Thorsten, Mak, Tak W, Clifton, Matthew C, Strong, Roland K, Ray, Prabir, Kolls, Jay K

“…Antimicrobial proteins comprise a significant component of the acute innate immune response to infection. They are induced by pattern recognition receptors as…”
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Activity of the De Novo Engineered Antimicrobial Peptide WLBU2 against Pseudomonas aeruginosa in Human Serum and Whole Blood: Implications for Systemic Applications by DESLOUCHES, Berthony, ISLAM, Kazi, CRAIGO, Jodi K, PARANJAPE, Shruti M, MONTELARO, Ronald C, MIETZNER, Timothy A

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De Novo Generation of Cationic Antimicrobial Peptides: Influence of Length and Tryptophan Substitution on Antimicrobial Activity by DESLOUCHES, Berthony, PHADKE, Shruti M, LAZAREVIC, Vanja, CASCIO, Michael, ISLAM, Kazi, MONTELARO, Ronald C, MIETZNER, Timothy A

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Evaluation of WLBU2 Peptide and 3-O-Octyl-sn-Glycerol Lipid as Active Ingredients for a Topical Microbicide Formulation Targeting Chlamydia trachomatis by SKINNER, M. C, KISELEV, A. O, ISAACS, C. E, MIETZNER, T. A, MONTELARO, R. C, LAMPE, M. F

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Role of Citrate and Phosphate Anions in the Mechanism of Iron(III) Sequestration by Ferric Binding Protein: Kinetic Studies of the Formation of the Holoprotein of Wild-Type FbpA and Its Engineered Mutants by Weaver, Katherine D, Gabričević, Mario, Anderson, Damon S, Adhikari, Pratima, Mietzner, Timothy A, Crumbliss, Alvin L

“…Ferric binding protein A (FbpA) plays a central role in the iron acquisition processes of pathogenic Neisseria gonorrheae, Neisseria meningitidis, and…”
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Sulfate as a Synergistic Anion Facilitating Iron Binding by the Bacterial Transferrin FbpA:  The Origins and Effects of Anion Promiscuity by Heymann, J. J, Weaver, K. D, Mietzner, T. A, Crumbliss, A. L

“…The ferric binding protein, FbpA, has been demonstrated to facilitate the transport of naked Fe3+ across the periplasmic space of several Gram-negative…”
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The Influence of the Synergistic Anion on Iron Chelation by Ferric Binding Protein, a Bacterial Transferrin by Dhungana, Suraj, Taboy, Céline H., Anderson, Damon S., Vaughan, Kevin G., Aisen, Philip, Mietzner, Timothy A., Crumbliss, Alvin L.

“…Although the presence of an exogenous anion is a requirement for tight Fe3+ binding by the bacterial (Neisseria) transferrin nFbp, the identity of the…”
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The hFbpABC Transporter from Haemophilus influenzae Functions as a Binding-Protein-Dependent ABC Transporter with High Specificity and Affinity for Ferric Iron by ANDERSON, Damon S, ADHIKARI, Pratima, NOWALK, Andrew J, CHEN, Cheng Y, MIETZNER, Timothy A

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Kinetics and mechanism of exogenous anion exchange in FeFbpA-NTA: significance of periplasmic anion lability and anion binding activity of ferric binding protein A by Heymann, Jared J, Gabričević, Mario, Mietzner, Timothy A, Crumbliss, Alvin L

“…The bacterial transferrin ferric binding protein A (FbpA) requires an exogenous anion to facilitate iron sequestration, and subsequently to shuttle the metal…”
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The Haemophilus influenzae hFbpABC Fe3+ Transporter: Analysis of the Membrane Permease and Development of a Gallium-Based Screen for Mutants by ANDERSON, Damon S, ADHIKARI, Pratima, WEAVER, Katherine D, CRUMBLISS, Alvin L, MIETZNER, Timothy A

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Structure of Haemophilus influenzae Fe +3 -binding protein reveals convergent evolution within a superfamily by Bruns, Christopher M, Nowalk, Andrew J, Arvai, Andrew S, McTigue, Michele A, Vaughan, Kevin G, Mietzner, Timothy A, McRee, Duncan E

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Fe3+ Coordination and Redox Properties of a Bacterial Transferrin by Taboy, Céline H., Vaughan, Kevin G., Mietzner, Timothy A., Aisen, Philip, Crumbliss, Alvin L.

“…The Fe3+ binding site of recombinant nFbp, a ferric-binding protein found in the periplasmic space of pathogenic Neisseria, has been characterized by…”
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Porträt chinesischer Arzneimittel by Mietzner, A.

“…Übergewicht kann aus Sicht der Chinesischen Medizin unterschiedliche Ursachen haben; Atractylodis macrocephalae Rhizoma ist ein Arzneimittel für die Gruppe von…”
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Kinetics and Mechanism of Iron(III) Complexation by Ferric Binding Protein:  The Role of Phosphate by Gabričević, Mario, Anderson, Damon S, Mietzner, Timothy A, Crumbliss, Alvin L

“…Iron transport across the periplasmic space to the cytoplasmic membrane of certain Gram-negative bacteria is mediated by a ferric binding protein (Fbp). This…”
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Hijacking transferrin bound iron: protein-receptor interactions involved in iron transport in N. gonorrhoeae by Siburt, Claire J Parker, Roulhac, Petra L, Weaver, Katherine D, Noto, Jennifer M, Mietzner, Timothy A, Cornelissen, Cynthia N, Fitzgerald, Michael C, Crumbliss, Alvin L

“…Neisseria gonorrhoeae has the capacity to acquire iron from its human host by removing this essential nutrient from serum transferrin. The transferrin binding…”
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Efficacy of the De Novo-Derived Antimicrobial Peptide WLBU2 against Oral Bacteria by NOVAK, Karen F, DIAMOND, William J, KIRAKODU, Sreenatha, PEYYALA, Rebecca, ANDERSON, Kimberly W, MONTELARO, Ronald C, MIETZNER, Timothy A

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Crystallographic and Biochemical Analyses of the Metal-Free Haemophilus influenzae Fe3+-Binding Protein by Bruns, Christopher M, Anderson, Damon S, Vaughan, Kevin G, Williams, Pamela A, Nowalk, Andrew J, McRee, Duncan E, Mietzner, Timothy A

“…The crystal structure of the iron-free (apo) form of the Haemophilus influenzae Fe3+-binding protein (hFbp) has been determined to 1.75 Å resolution…”
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Modulation of proinflammatory activity by the engineered cationic antimicrobial peptide WLBU-2 [version 1; peer review: 2 approved] by Paranjape, Shruti M, Lauer, Thomas W, Montelaro, Ronald C, Mietzner, Timothy A, Vij, Neeraj

“…Background: Host-derived (LL-37) and synthetic (WLBU-2) cationic antimicrobial peptides (CAPs) are known for their membrane-active bactericidal properties…”
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Antimicrobial peptides in mucosal secretions: the importance of local secretions in mitigating infection by Phadke, Shruti M, Deslouches, Berthony, Hileman, Sara E, Montelaro, Ronald C, Wiesenfeld, Harold C, Mietzner, Timothy A

“…The antimicrobial activity of the collective molecules comprising human milk reflects an evolutionarily successful paradigm for preventing and limiting…”
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