Search Results - "Miettinen, H. M."

Toxoplasma gondii: fusion competence of parasitophorous vacuoles in Fc receptor-transfected fibroblasts by Joiner, K. A., Fuhrman, S. A., Miettinen, H. M., Kasper, L. H., Mellman, I.

“…After actively entering its host cells, the protozoan parasite Toxoplasma gondii resides in an intracellular vacuole that is completely unable to fuse with…”
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Syndecan Expression Regulates Cell Morphology and Growth of Mouse Mammary Epithelial Tumor Cells by Leppa, Sirpa, Mali, Markku, Miettinen, Heini M., Jalkanen, Markku

“…S115 mouse mammary epithelial cells lose their epithelial morphology and become tumorigenic when exposed to steroids. We have recently reported that…”
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Inhibition of basic fibroblast growth factor-induced growth promotion by overexpression of syndecan-1 by MALI, MARKKU, ELENIUS, K, MIETTINEN, H. M, JALKANEN, M

“…The expression of syndecan-1, the prototype member of the cell surface proteoglycan family, follows morphogenetic rather than histological boundaries during…”
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A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in inhibition of desensitization and endocytosis, and a dose-dependent shift in p42/44 mitogen-activated protein kinase activation and chemotaxis by Gripentrog, J M, Jesaitis, A J, Miettinen, H M

“…The formyl peptide receptor (FPR) is a G-protein-coupled receptor (GPCR) that mediates chemotaxis and stimulates the mitogen-activated protein kinase…”
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Fc receptor isoforms exhibit distinct abilities for coated pit localization as a result of cytoplasmic domain heterogeneity by Miettinen, H M, Rose, J K, Mellman, I

“…Mouse macrophages and lymphocytes express two distinct isoforms of a single class of Fc receptor for IgG. The macrophage isoform (FcRII-B2) is identical to the…”
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Suppression of tumor cell growth by syndecan-1 ectodomain by Mali, M, Andtfolk, H, Miettinen, H M, Jalkanen, M

“…Syndecans are integral membrane proteoglycans characterized by the similarity of cytoplasmic and transmembrane domains of the core proteins. Syndecans may…”
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Expression of syndecan-1 is induced by differentiation and suppressed by malignant transformation of human keratinocytes by Inki, P, Larjava, H, Haapasalmi, K, Miettinen, H M, Grenman, R, Jalkanen, M

“…Syndecans comprise a family of integral membrane proteoglycans that presumably participate in cell-matrix interactions and the modulation of growth factor…”
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Fc Receptor Endocytosis Is Controlled by a Cytoplasmic Domain Determinant That Actively Prevents Coated Pit Localization by Miettinen, Heini M., Matter, Karl, Hunziker, Walter, Rose, John K., Mellman, Ira

“…Macrophages and B-lymphocytes express two major isoforms of Fc receptor (FcRII-B2 and FcRII-B1) that exhibit distinct capacities for endocytosis. This…”
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The ligand binding site of the formyl peptide receptor maps in the transmembrane region by Miettinen, HM, Mills, JS, Gripentrog, JM, Dratz, EA, Granger, BL, Jesaitis, AJ

“…We propose that the N-formyl-Met-Leu-Phe binding site in the human neutrophil formyl peptide receptor (FPR) lies in the predicted transmembrane region. We…”
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Ten-year prognosis of Puumala hantavirus-induced acute interstitial nephritis by Miettinen, M.H., Mäkelä, S.M., Ala-Houhala, I.O., Huhtala, H.S.A., Kööbi, T., Vaheri, A.I., Pasternack, A.I., Pörsti, I.H., Mustonen, J.T.

“…Nephropathia epidemica (NE) is a hemorrhagic fever with renal syndrome caused by Puumala hantavirus. Its long-term prognosis is considered favorable. There…”
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Non-serum-dependent chemotactic factors produced by Candida albicans stimulate chemotaxis by binding to the formyl peptide receptor on neutrophils and to an unknown receptor on macrophages by EDENS, H. A, PARKOS, C. A, LIANG, T. W, JESAITIS, A. J, CUTLER, J. E, MIETTINEN, H. M

“…Serum-free culture filtrates of six Candida species and Saccharomyces cerevisiae were found to contain chemoattractants for human polymorphonuclear leukocytes…”
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The cytoplasmic domain of syndecan-1 is not required for association with Triton X-100-insoluble material by MIETTINEN, H. M, JALKANEN, M

“…Cell surface heparan sulfate proteoglycans such as syndecan-1 bind various extracellular matrix proteins and have been suggested to interact with the…”
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The role of AhR in doxin-induced modulation of bone microarchitecture and mechanical strength by Herlin, Maria, Aula, Antti, Miettinen, Hanna M., Korkalainen, Merja, Finnilä, Mikko, Tuukkanen, Juha, Håkansson, Helen, Viluksela, Matti

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Effect of in Utero and Lactational 2,3,7,8-Tetrachlorodibenzo- p-dioxin Exposure on Rat Molar Development: The Role of Exposure Time by Miettinen, Hanna M., Alaluusua, Satu, Tuomisto, Jouko, Viluksela, Matti

“…We have previously shown that tooth development is a sensitive endpoint of dioxin toxicity. In the present study we determined the critical window of…”
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Effects of perinatal exposure to high purity PCB180 on rat offspring by Miettinen, Hanna M., Heikkinen, Päivi, Korkalainen, Merja, Antunes-Fernandes, Elsa, van Duursen, Majorie, Leslie, Heather, Hamscher, Gerd, Andersson, Patrik L., Halldin, Krister, Håkansson, Helen, Viluksela, Matti

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ATHON NDL-PCB effect database—A tool to facilitate the cumulative risk assessment of NDL-PCBs by Westerholm, Emma, Boix, Jordi, Miettinen, Hanna M., Roos, Robert, Antunes-Fernandes, Elsa, Westerink, Remco, van Duursen, Majorie, Stenberg, Maria, Carreira, Sara Correia, Machala, Miroslav, Silins, Ilona, Stenius, Ulla, Halldin, Krister, Hanberg, Annika, Håkansson, Helen

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Characterization of the Binding Site on the Formyl Peptide Receptor Using Three Receptor Mutants and Analogs of Met-Leu-Phe and Met-Met-Trp-Leu-Leu by Mills, John S., Miettinen, Heini M., Cummings, David, Jesaitis, Algirdas J.

“…The formyl peptide receptor (FPR) is a chemotactic G protein-coupled receptor found on the surface of phagocytes. We have previously shown that the formyl…”
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Toxicological profile of high purity PCB 180 in adult rats by Viluksela, Matti, Heikkinen, Päivi, van der Ven, Leo, Miettinen, Hanna M., Korkalainen, Merja, Savolainen, Kari, Lilienthal, Hellmuth, Adamsson, Annika, Toppari, Jorma, Finnilä, Mikko, Tuukkanen, Juha, Hamscher, Gerd, Andersson, Patrik L., Schrenk, Dieter, Halldin, Krister, Håkansson, Helen

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Experimental Evidence for Lack of Homodimerization of the G Protein-Coupled Human N-Formyl Peptide Receptor by Gripentrog, Jeannie M, Kantele, Katrin P, Jesaitis, Algirdas J, Miettinen, Heini M

“…A large number of G protein-coupled receptors have been shown to form homodimers based on a number of different techniques such as receptor…”
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399 MUTATIONS OF F110 AND C126 OF THE FORMYL PEPTIDE RECEPTOR INTERFERE WITH G-PROTEIN COUPLING AND CHEMOTAXIS by Jones, B. E., Miettinen, H. M., Jesaitis, A. J., Mills, J. S.

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