Search Results - "Mies, Anna"

Machine learning assisted real-time deformability cytometry of CD34+ cells allows to identify patients with myelodysplastic syndromes by Herbig, Maik, Jacobi, Angela, Wobus, Manja, Weidner, Heike, Mies, Anna, Kräter, Martin, Otto, Oliver, Thiede, Christian, Weickert, Marie‑Theresa, Götze, Katharina S., Rauner, Martina, Hofbauer, Lorenz C., Bornhäuser, Martin, Guck, Jochen, Ader, Marius, Platzbecker, Uwe, Balaian, Ekaterina

“…Diagnosis of myelodysplastic syndrome (MDS) mainly relies on a manual assessment of the peripheral blood and bone marrow cell morphology. The WHO guidelines…”
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Tracking myeloid malignancies by targeted analysis of successive DNA methylation at neighboring CG dinucleotides by Eipel, Monika, Božić, Tanja, Mies, Anna, Beier, Fabian, Jost, Edgar, Brümmendorf, Tim H, Platzbecker, Uwe, Wagner, Wolfgang

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Alterations within the Osteo-Hematopoietic Niche in MDS and their Therapeutic Implications by Mies, Anna, Bulycheva, Ekaterina, Rogulj, Inga Mandac, Hofbauer, Lorenz C, Platzbecker, Uwe

“…Hematopoietic and mesenchymal stem and progenitor cells are organized in the osteo-hematopoietic niche, a complex microenvironment ensuring self-renewal and…”
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Autophagy inhibition promotes defective neosynthesized proteins storage in ALIS, and induces redirection toward proteasome processing and MHCI-restricted presentation by Wenger, Till, Terawaki, Seigo, Camosseto, Voahirana, Abdelrassoul, Ronza, Mies, Anna, Catalan, Nadia, Claudio, Nuno, Clavarino, Giovanna, de Gassart, Aude, Rigotti, Francesca de Angelis, Gatti, Evelina, Pierre, Philippe

“…A significant portion of newly synthesized protein fails to fold properly and is quickly degraded. These defective ribosomal products (DRiPs) are substrates…”
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Increasing the effectiveness of hematopoiesis in myelodysplastic syndromes: erythropoiesis-stimulating agents and transforming growth factor-β superfamily inhibitors by Mies, Anna, Platzbecker, Uwe

“…Patients with lower-risk myelodysplastic syndromes (MDS) are mainly affected by chronic anemia and fatigue. Treatment strategies aim to improve anemia and…”
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Diagnostic approach to polyarticular joint pain by Mies Richie, Anna, Francis, Mark L

“…Identifying the cause of polyarticular joint pain can be difficult because of the extensive differential diagnosis. A thorough history and a complete physical…”
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Activin Receptor II Ligand Traps and Their Therapeutic Potential in Myelodysplastic Syndromes with Ring Sideroblasts by Mies, Anna, Hermine, Olivier, Platzbecker, Uwe

“…Distinct subtypes of lower risk myelodysplastic syndromes display ring sideroblasts in the bone marrow, i. e., erythroid progenitors characterized by excessive…”
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Luspatercept restores SDF-1-mediated hematopoietic support by MDS-derived mesenchymal stromal cells by Wobus, Manja, Mies, Anna, Asokan, Nandini, Oelschlägel, Uta, Möbus, Kristin, Winter, Susann, Cross, Michael, Weidner, Heike, Rauner, Martina, Hofbauer, Lorenz C., Bornhäuser, Martin, Platzbecker, Uwe

“…The bone marrow microenvironment (BMME) plays a key role in the pathophysiology of myelodysplastic syndromes (MDS), clonal blood disorders affecting the…”
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Altered Structure and Function of Mesenchymal Stromal Cell-Derived Extracellular Matrix in MDS Can be Restored By Luspatercept by Wobus, Manja, Mies, Anna, Magno, Valentina, Welzel, Cindy, Winter, Susann, Stoelzel, Friedrich, Werner, Carsten, Bornhaeuser, Martin, Platzbecker, Uwe

“…Introduction The involvement of the bone marrow microenvironment (BMME) into disease progression and therapeutic response of myelodysplastic syndromes (MDS) is…”
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Single agent talacotuzumab demonstrates limited efficacy but considerable toxicity in elderly high-risk MDS or AML patients failing hypomethylating agents by Kubasch, Anne Sophie, Schulze, Freya, Giagounidis, Aristoteles, Götze, Katharina S., Krönke, Jan, Sockel, Katja, Middeke, Jan Moritz, Chermat, Fatiha, Gloaguen, Silke, Puttrich, Martin, Weigt, Carmen, William, Doreen, Fenaux, Pierre, Schlenk, Richard F., Thiede, Christian, Stasik, Sebastian, Mies, Anna, Adès, Lionel, Oelschlägel, Uta, Platzbecker, Uwe

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Impairment of the Stromal SDF-1-Mediated Hematopoietic Support By GDF-11 in MDS Is Rescued By Luspatercept by Wobus, Manja, Mies, Anna, Asokan, Nandini, Oelschlaegel, Uta, Winter, Susann, Rauner, Martina, Hofbauer, Lorenz, Bornhäuser, Martin, Platzbecker, Uwe

“…Introduction: Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis due to genetic and functional abnormalities of hematopoietic stem…”
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Effects of rigosertib on the osteo-hematopoietic niche in myelodysplastic syndromes by Balaian, Ekaterina, Weidner, Heike, Wobus, Manja, Baschant, Ulrike, Jacobi, Angela, Mies, Anna, Bornhäuser, Martin, Guck, Jochen, Hofbauer, Lorenz C., Rauner, Martina, Platzbecker, Uwe

“…Rigosertib is a novel multi-kinase inhibitor, which has clinical activity towards leukemic progenitor cells of patients with high-risk myelodysplastic…”
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Epigenetic Biomarkers Are Applicable for Risk Stratification in Myelodysplastic Syndromes by Mies, Anna, Božić, Tanja, Kramer, Michael, Franzen, Julia, Ehninger, Gerhard, Bornhäuser, Martin, Platzbecker, Uwe, Wagner, Wolfgang

“…Introduction: Myelodysplastic syndromes (MDS) are frequently associated with somatic mutations in epigenetic modifiers such as de novo methyltransferase 3A…”
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Associations of myeloid hematological diseases of the elderly with osteoporosis: A longitudinal analysis of routine health care data by Datzmann, Thomas, Trautmann, Freya, Tesch, Falko, Mies, Anna, Hofbauer, Lorenz C., Platzbecker, Uwe, Schmitt, Jochen

“…•Clinically relevant relationship between Myelodysplastic Syndromes and osteoporosis.•Additional risk of 87% for osteoporosis in patients with pre-existing…”
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Prospective validation of a biomarker-driven response prediction model to romiplostim in lower-risk myelodysplastic neoplasms – results of the EUROPE trial by EMSCO by Kubasch, Anne Sophie, Giagounidis, Aristoteles, Metzgeroth, Georgia, Jonasova, Anna, Herbst, Regina, Diaz, Jose Miguel Torregrosa, De Renzis, Benoit, Götze, Katharina S., Huetter-Kroenke, Marie-Luise, Gourin, Marie-Pierre, Slama, Borhane, Dimicoli-Salazar, Sophie, Cony-Makhoul, Pascale, Laribi, Kamel, Park, Sophie, Jersemann, Katja, Schipp, Dorothea, Metzeler, Klaus H., Tiebel, Oliver, Sockel, Katja, Gloaguen, Silke, Mies, Anna, Chermat, Fatiha, Thiede, Christian, Sapena, Rosa, Schlenk, Richard F., Fenaux, Pierre, Platzbecker, Uwe, Adès, Lionel

“…The EUROPE phase 2 trial investigated the predictive value of biomarkers on the clinical efficacy of single agent romiplostim (ROM) treatment in patients with…”
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Anti-CD123 Targeted Therapy with Talacotuzumab in Advanced MDS and AML after Failing Hypomethylating Agents - Final Results of the Samba Trial by Kubasch, Anne Sophie, Schulze, Freya, Götze, Katharina S., Krönke, Jan, Sockel, Katja, Middeke, Jan Moritz, Chermat, Fatiha, Gloaguen, Silke, Puttrich, Martin, Weigt, Carmen, Jersemann, Katja, Fenaux, Pierre, Schlenk, Richard F., Giagounidis, Aristoteles, Ades, Lionel, Mies, Anna, Oelschlaegel, Uta, Platzbecker, Uwe

“…Introduction Recently, progress has been made in the treatment of patients with higher risk myelodysplastic syndromes (HR MDS) and acute myeloid leukemia…”
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A Molecular-Based Response Prediction Model to Romiplostim in Patients with Lower-Risk Myelodysplastic Syndrome and Severe Thrombocytopenia by Kubasch, Anne Sophie, Giagounidis, Aristoteles, Metzgeroth, Georgia, Jonasova, Anna, Herbst, Regina, Torregrosa Diaz, Jose Miguel, De Renzis, Benoit, Götze, Katharina S., Huetter-Kroenke, Marie-Luise, Gourin, Marie-Pierre, Slama, Bohrane, Dimicoli-Salazar, Sophie, Cony-Makhoul, Pascale, Laribi, Kamel, Park, Sophie, Jersemann, Katja, Schipp, Dorothea, Metzeler, Klaus H., Tiebel, Oliver, Sockel, Katja, Gloaguen, Silke, Mies, Anna, Chermat, Fatiha, Thiede, Christian, Sapena, Rosa, Schlenk, Richard F., Fenaux, Pierre, Platzbecker, Uwe, Ades, Lionel

“…*UP, LA contributed equally Introduction A significant proportion of lower risk (LR)-MDS patients present with thrombocytopenia, being associated with…”
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Biomarkers of Response to Romiplostim in Patients with Lower-Risk Myelodysplastic Syndrome (MDS) and Thrombocytopenia - Results of the Europe Trial By the Emsco Network by Platzbecker, Uwe, Kubasch, Anne Sophie, Giagounidis, Aristoteles, Metzgeroth, Georgia, Jonasova, Anna, Herbst, Regina, Torregrosa Diaz, Jose Miguel, De Renzis, Benoit, Götze, Katharina, Huetter-Kroenke, Marie-Luise, Gourin, Marie-Pierre, Slama, Borhane, Dimicoli-Salazar, Sophie, Cony-Makhoul, Pascale, Laribi, Kamel, Park, Sophie, Jersemann, Katja, Tiebel, Oliver, Sockel, Katja, Gloaguen, Silke, Mies, Anna, Chermat, Fatiha, Thiede, Christian, Sapena, Rosa, Schlenk, Richard F., Fenaux, Pierre, Ades, Lionel

“…Introduction: Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis and peripheral cytopenia. In about half of patients with…”
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Mutation Profile of PPM1D and TP53 in Patients with Myelodysplastic Syndromes and Complex Chromosome Abnormalities by Eder, Lea Naomi, Ganster, Christina, Shirneshan, Katayoon, Germing, Ulrich, Elmaagacli, Ahmet H., Mies, Anna, Hertenstein, Bernd, Simon-Becker, Susanne, Platzbecker, Uwe, Dierks, Sascha, Rittscher, Katharina, Schaab, Roxana, Martin, Roman, Söling, Ulrike, Heudobler, Daniel, Lange, Frank, Hildebrandt, Barbara, Glass, Bertram, Braulke, Friederike, Schanz, Julie, Haase, Detlef

“…Introduction: Complex (≥3) abnormalities (cA) are associated with an inferior outcome in myelodysplastic syndromes (MDS). About 50% of MDS with cA show…”
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TP53 Status As Well As Cytogenetic Complexity Significantly Impact on Prognosis in Myelodysplastic Syndromes with Complex (≥3 anomalies) Aberrant Karyotypes by Ganster, Christina, Schaab, Roxana, Shirneshan, Katayoon, Eder, Lea Naomi, Mies, Anna, Germing, Ulrich, Elmaagacli, Ahmet, Sole, Francesc, Palomo, Laura, Kaivers, Jennifer, Söling, Ulrike, Lange, Frank, Kröger, Nicolaus, Hertenstein, Bernd, Döhner, Konstanze, Bug, Gesine, Hildebrandt, Barbara, Talló Parra, Marc, Nickelsen, Maike, Glass, Bertram, Platzbecker, Uwe, Bacher, Ulrike, Braulke, Friederike, Schanz, Julie, Haase, Detlef

“…Introduction: Complex aberrant karyotypes (CK, ≥3 cytogenetic aberrations, CA) are associated with an unfavorable prognosis and an increased AML transformation…”
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