Search Results - "Mierzchala, Magdalena"
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Effect of a 3% gelatin solution on urinary KIM-1 levels in patients after thyroidectomy: a preliminary randomized controlled trial
Published in Scientific reports (08-12-2021)“…Optimal fluid therapy significantly affects the maintenance of proper tissue perfusion and, consequently, kidney function. An adverse effect of colloids on…”
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Renin as a Marker of Tissue Perfusion, Septic Shock and Mortality in Septic Patients: A Prospective Observational Study
Published in International journal of molecular sciences (15-08-2022)“…Sepsis is a life-threatening organ dysfunction caused by the dysregulation of the host’s response to an infection, where the dominant mechanism is tissue…”
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An analysis of urine and serum amino acids in critically ill patients upon admission by means of targeted LC–MS/MS: a preliminary study
Published in Scientific reports (07-10-2021)“…Sepsis, defined as a dysregulated host response to infection, causes the interruption of homeostasis resulting in metabolic changes. An examination of patient…”
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Modulating Properties of Piroxicam, Meloxicam and Oxicam Analogues against Macrophage-Associated Chemokines in Colorectal Cancer
Published in Molecules (Basel, Switzerland) (05-12-2021)“…The mechanisms underlying the antineoplastic effects of oxicams have not been fully elucidated. We aimed to assess the effect of classic and novel oxicams on…”
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Altered L-Arginine Metabolic Pathways in Gastric Cancer: Potential Therapeutic Targets and Biomarkers
Published in Biomolecules (Basel, Switzerland) (23-07-2021)“…There is a pressing need for molecular targets and biomarkers in gastric cancer (GC). We aimed at identifying aberrations in L-arginine metabolism with…”
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Impact of chronic wounds of various etiology on systemic profiles of key inflammatory cytokines, chemokines, and growth factors and their interplay
Published in Advances in clinical and experimental medicine : official organ Wroclaw Medical University (01-10-2019)“…Non-healing wounds are becoming a growing concern for public health as a result of their increasing prevalence in progressively aging societies. The aim of…”
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Circulating adipocyte fatty acid-binding protein, juvenile obesity, and metabolic syndrome
Published in Journal of pediatric endocrinology & metabolism : JPEM (2011)“…Adipocyte fatty acid-binding protein (A-FABP) links obesity and metabolic syndrome (MetS) and might be targeted in future therapies. Its utility as a MetS…”
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Sepsis diagnosis and monitoring - procalcitonin as standard, but what next?
Published in Anaesthesiology intensive therapy : official publication of the Polish Society of Anaesthesiology and Intensive Therapy (01-01-2019)“…Sepsis is a life-threatening organ dysfunction caused by a systemic altered host response to infection. According to the newest guidelines the sepsis treatment…”
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Measurement of Serum Levels of 5 Amino Acids and Dimethylamine Using Liquid Chromatography-Tandem Mass Spectrometry in Patients without Septic Associated Acute Kidney Injury and with Septic Associated Acute Kidney Injury Requiring Continuous Renal Replacement Therapy
Published in Medical science monitor (07-09-2022)“…BACKGROUND Acute kidney injury (AKI) is one of the most common organ failures. An early diagnosis of AKI using specific biomarkers is essential for effective…”
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L-Arginine/Nitric Oxide Pathway Is Altered in Colorectal Cancer and Can Be Modulated by Novel Derivatives from Oxicam Class of Non-Steroidal Anti-Inflammatory Drugs
Published in Cancers (11-09-2020)“…L-arginine/nitric oxide pathway metabolites are altered in colorectal cancer (CRC). We evaluated underlying changes in pathway enzymes in 55 paired…”
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Experimental and bioinformatic approach to identifying antigenic epitopes in human α- and β-enolases
Published in Biochemistry and biophysics reports (01-09-2018)“…Human α- and β-enolases are highly homologous enzymes, difficult to differentiate immunologically. In this work, we describe production, purification and…”
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The composition, biochemical properties and toxicity of snake venoms
Published in Postȩpy higieny i medycyny doświadczalnej (28-05-2010)“…2.5 million cases of snake bites are noticed in the world every year (within 100,000 is mortal). These bites occur frequently in Asia and Africa. Some reports…”
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The effect of packed red blood cell storage on arachidonic acid and advanced glycation end-product formation
Published in Archivum Immunologiae et Therapiae Experimentalis (01-10-2006)“…The transfusion of packed red blood cells (PRBCs) is a significant risk to blood recipients. Blood banking procedures permit the storage of PRBCs for up to 42…”
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Serum and Erythrocyte Antioxidant Defense in Colorectal Cancer Patients during Early Postoperative Period: Potential Modifiers and Impact on Clinical Outcomes
Published in Antioxidants (23-06-2021)“…A better understanding of antioxidant status, its modifiers, and its effect on clinical outcomes in patients undergoing colorectal cancer surgery is needed for…”
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Midkine, a multifunctional cytokine, in patients with severe sepsis and septic shock: a pilot study
Published in Shock (Augusta, Ga.) (01-05-2011)“…The objective of the study was to evaluate whether severe sepsis and septic shock are related to alterations in midkine concentrations, to identify…”
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Quantitative indices of dynamics in concentrations of lipopolysaccharide-binding protein (LBP) as prognostic factors in severe sepsis/septic shock patients — Comparison with CRP and procalcitonin
Published in Clinical biochemistry (01-04-2011)“…To devise and evaluate quantitative indices of dynamics in lipopolysaccharide-binding protein (LBP), CRP, and procalcitonin concentrations as prognostic…”
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Specific plasma amino acid disturbances associated with metabolic syndrome
Published in Endocrine (01-12-2017)“…Purpose The primary objective of the present study was to examine the association between branched chain and aromatic amino acid profiles (BCAA and AAA…”
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Procalcitonin kinetics - prognostic and diagnostic significance in septic patients
Published in Archives of medical science (01-02-2016)“…Severe sepsis and septic shock are advanced clinical conditions representing the patient's response to infection and having a variable but high mortality rate…”
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Does the Serum Concentration of Angiotensin II Type 1 Receptor Have an Effect on the Severity of COVID-19? A Prospective Preliminary Observational Study among Healthcare Professionals
Published in Journal of clinical medicine (23-03-2022)“…SARS-CoV-2 is a virus that causes severe respiratory distress syndrome. The pathophysiology of COVID-19 is related to the renin-angiotensin system (RAS)…”
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