Carboxylation of Osteocalcin Affects Its Association With Metabolic Parameters in Healthy Children

OBJECTIVE: Osteocalcin (OC), a bone-derived protein, was recently shown to regulate metabolic pathways in mice. Undercarboxylated OC (ucOC), but not carboxylated OC (cOC), increases adiponectin and insulin secretion. It is unclear if carboxylation of OC affects its association with metabolic paramet...

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Published in:	Diabetes care Vol. 33; no. 3; pp. 661 - 663
Main Authors:	Prats-Puig, Anna, Mas-Parareda, Marta, Riera-Pérez, Elena, González-Forcadell, Dolors, Mier, Concepció, Mallol-Guisset, Montserrat, Díaz, Marta, Bassols, Judit, de Zegher, Francis, Ibáñez, Lourdes, López-Bermejo, Abel
Format:	Journal Article
Language:	English
Published:	Alexandria, VA American Diabetes Association 01-03-2010
Subjects:	Adiponectin - chemistry Adiponectin - metabolism Analysis Biological and medical sciences Biomarkers - metabolism Biomedical research Body Weight - physiology Carboxyl and Carbamoyl Transferases - metabolism Child Child, Preschool Children Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Health Homeostasis - physiology Humans Insulin Resistance - physiology Male Medical sciences Metabolic diseases Metabolic disorders Metabolism Metabolism - physiology Miscellaneous Molecular Weight Obesity in children Original Research Osteocalcin - chemistry Osteocalcin - metabolism Osteocalcin - physiology Protein Processing, Post-Translational - physiology Public health. Hygiene Public health. Hygiene-occupational medicine Studies Human Osteocalcin Association Nutrition Carboxylation Metabolic diseases Metabolism Child Endocrinology
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Summary:	OBJECTIVE: Osteocalcin (OC), a bone-derived protein, was recently shown to regulate metabolic pathways in mice. Undercarboxylated OC (ucOC), but not carboxylated OC (cOC), increases adiponectin and insulin secretion. It is unclear if carboxylation of OC affects its association with metabolic parameters in humans. RESEARCH DESIGN AND METHODS: The associations between ucOC, cOC, total and high-molecular-weight (HMW) adiponectin, and insulin secretion (homeostasis model assessment [HOMA]-β) were investigated in a population-based sample of healthy prepubertal children (n = 103; 49 boys and 54 girls). RESULTS: Weight-dependent associations were observed between the different forms of OC and metabolic parameters. Higher cOC was related to lower HMW adiponectin (with a stronger association in leaner children; P < 0.001). Higher ucOC-to-cOC ratio was associated with higher HOMA-β (P < 0.01) in leaner children and associated with higher HMW adiponectin (P < 0.001) in heavier children. CONCLUSIONS: In a weight-dependent manner, cOC and the proportion of ucOC are differentially related to HMW adiponectin and insulin secretion in healthy children.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0149-5992 1935-5548
DOI:	10.2337/dc09-1837