Search Results - "Mien, L K"

Simple and rapid preparation of [11C]DASB with high quality and reliability for routine applications by Haeusler, D., Mien, L.-K., Nics, L., Ungersboeck, J., Philippe, C., Lanzenberger, R.R., Kletter, K., Dudczak, R., Mitterhauser, M., Wadsak, W.

“…[11C]DASB combines all major prerequisites for a successful SERT-ligand, providing excellent biological properties and in-vivo behaviour. Thus, we aimed to…”
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“Label and go” – A fast and easy radiolabelling method for pellets by Philippe, C., Mien, L.-K., Salar-Behzadi, S., Knäusl, B., Wadsak, W., Dudczak, R., Kletter, K., Viernstein, H., Mitterhauser, M.

“…For the development and process optimization of pharmaceutical equipment, it is important to investigate the underlying processes. Taking the fluidized bed…”
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Influence of escitalopram treatment on 5-HT 1A receptor binding in limbic regions in patients with anxiety disorders by Spindelegger, C, Lanzenberger, R, Wadsak, W, Mien, L K, Stein, P, Mitterhauser, M, Moser, U, Holik, A, Pezawas, L, Kletter, K, Kasper, S

“…There is an increasing interest in the underlying mechanisms of the antidepressant and anxiolytic treatment effect associated with changes in serotonergic…”
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Influence of escitalopram treatment on 5-HT1A receptor binding in limbic regions in patients with anxiety disorders by Spindelegger, C, Lanzenberger, R, Wadsak, W, Mien, L K, Stein, P, Mitterhauser, M, Moser, U, Holik, A, Pezawas, L, Kletter, K, Kasper, S

“…There is an increasing interest in the underlying mechanisms of the antidepressant and anxiolytic treatment effect associated with changes in serotonergic…”
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PW01-155 - Seasonal alterations of serotonin-1A receptor binding in the healthy human brain by Spindelegger, C, Stein, P, Wadsak, W, Fink, M, Mitterhauser, M, Moser, U, Savli, M, Mien, L.-K, Akimova, E, Hahn, A, Willeit, M, Kletter, K, Kasper, S, Lanzenberger, R

“…Objectives Serotonergic neurotransmission plays a key role in seasonal changes of mood and behaviour. Higher serotonin transporter availability in healthy…”
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Binding studies of [ 18F]-fluoride and polyphosphonates radiolabelled with [ 99mTc], [ 111In], [ 153Sm] and [ 188Re] on bone compartments: Verification of the pre vivo model? by Mitterhauser, Markus, Toegel, Stefan, Wadsak, Wolfgang, Mien, Leonhard-Key, Eidherr, Harald, Kletter, Kurt, Viernstein, Helmut, Kluger, Rainer, Engel, Alfred, Dudczak, Robert

“…Although the first polyphosphonates (PP) were introduced to nuclear medicine as bone imagers in the early 70s, mechanisms involved in uptake still remain…”
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Reduced Serotonin-1A Receptor Binding in Social Anxiety Disorder by Lanzenberger, Rupert R, Mitterhauser, Markus, Spindelegger, Christoph, Wadsak, Wolfgang, Klein, Nikolas, Mien, Leonhard-Key, Holik, Alexander, Attarbaschi, Trawat, Mossaheb, Nilufar, Sacher, Julia, Geiss-Granadia, Thomas, Kletter, Kurt, Kasper, Siegfried, Tauscher, Johannes

“…Background Results from studies in serotonin-1A (5-HT1A ) knockout mice and previous positron emission tomography (PET) studies in humans imply a role for…”
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Influence of escitalopram treatment on 5-HT sub(1A) receptor binding in limbic regions in patients with anxiety disorders by Spindelegger, C, Lanzenberger, R, Wadsak, W, Mien, L K, Stein, P, Mitterhauser, M, Moser, U, Holik, A, Pezawas, L, Kletter, K, Kasper, S

“…There is an increasing interest in the underlying mechanisms of the antidepressant and anxiolytic treatment effect associated with changes in serotonergic…”
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Preparation and first evaluation of [ super(18)F]FE SUPPY: a new PET tracer for the adenosine A sub(3) receptor by Wadsak, W, Mien, L-K, Shanab, K, Ettlinger, DE, Haeusler, D, Sindelar, K, Lanzenberger, R R, Spreitzer, H, Viernstein, H, Keppler, B K, Dudczak, R, Kletter, K, Mitterhauser, M

“…Introduction: Changes of the adenosine A sub(3) receptor subtype (A3AR) expression have been shown in a variety of pathologies, especially neurological and…”
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Uptake of bone-seekers is solely associated with mineralisationl A study with super(99m)Tc-MDP, super(153)Sm-EDTMP and super(18)F-fluoride on osteoblasts by Toegel, S, Hoffmann, O, Wadsak, W, Ettlinger, D, Mien, L-K, Wiesner, K, Nguemo, J, Viernstein, H, Kletter, K, Dudczak, R, Mitterhauser, M

“…Purpose Although polyphosphonates (PPs) were introduced as bone imaging agents in nuclear medicine in the early 1970s, the mechanisms involved in their uptake…”
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Serotonin-1A receptor binding and Reward-dependent Activation are associated within the Human Dorsal Raphe Nucleus as revealed by PET-fMRI by Lanzenberger, R., Hahn, A., Windischberger, C., Wadsak, W., Holik, A., Gerstl, F., Savli, M., Moser, U., Mien, L.K., Akimova, E., Mitterhauser, M., Kletter, K., Moser, E., Kasper, S.

“…The tonic activity of these serotonergic neurons is regulated by auto-inhibition via somatodendritic serotonin-1A (5-HT1A) receptors in the DRN. [...]we would…”
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Serotonin transporter availability in dorsal raphe nucleus predicts serotonin-1A receptor binding in striatum —A multitracer PET study with [ Carbonyl-11C]WAY and [ 11C]DASB by Lanzenberger, Rupert, Wadsak, W., Savli, M., Mitterhauser, M., Fink, M., Mien, L.K., Hahn, A., Haeusler, D., Spindelegger, C., Moser, U., Stein, P., Kletter, K., Kasper, S.

“…Combined PET and fMRI studies have shown that the 5-HT1A autoreceptor binding potential (BP) and regional 5-HTT BP predict amygdala activation [2, 3]. [...]the…”
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Regional relationships of serotonin transporter and serotonin-1A receptor in human brain revealed by PET by Savli, Markus, Haeusler, D., Fink, M., Hahn, A., Spindelegger, C., Moser, U., Mien, L.K., Mitterhauser, M., Wadsak, W., Stein, P., Kletter, K., Kasper, S., Lanzenberger, R.

“…Six regions of interest (ROIs) were investigated: dorsal raphe nucleus (DRN) and striatum including nucleus caudatus and putamen expressing high levels of 5-HT…”
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Absence of sex differences in the serotonin-1A receptor binding in healthy women and men measured by PET by Stein, Patrycja, Fink, M., Hahn, A., Spindelegger, C., Mitterhauser, M., Wadsak, W., Moser, U., Savli, M., Mien, L.K., Lanzenberger, R., Kletter, K., Kasper, S.

“…For the manual method, nine regions of interest (ROIs; anterior and posterior cingulate cortex, amygdala, hippocampus, insula, orbitofrontal cortex,…”
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Synthesis and biodistribution of [18F]FE@CIT, a new potential tracer for the dopamine transporter by Mitterhauser, Markus, Wadsak, Wolfgang, Mien, Leonhard-Key, Hoepping, Alexander, Viernstein, Helmut, Dudczak, Robert, Kletter, Kurt

“…In the last decade radiolabeled tropane analogs based on β‐CIT have proven indispensable for the imaging of the dopamine transporter. However, further…”
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Biological evaluation of 2′-[ 18F]fluoroflumazenil ([ 18F]FFMZ), a potential GABA receptor ligand for PET by Mitterhauser, Markus, Wadsak, Wolfgang, Wabnegger, Leila, Mien, Leonhard-Key, Tögel, Stefan, Langer, Oliver, Sieghart, Werner, Viernstein, Helmut, Kletter, Kurt, Dudczak, Robert

“…[ 11C]Flumazenil, a highly selective benzodiazepine antagonist is the most extensively used GABA A ligand for PET so far. To overcome half life disadvantages…”
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Binding studies of [ 18F]-fluoride and polyphosphonates radiolabelled with [ 111In], [ 99mTc], [ 153Sm], and [ 188Re] on bone compartments: a new model for the pre vivo evaluation of bone seekers? by Mitterhauser, Markus, Tögel, Stefan, Wadsak, Wolfgang, Mien, Leonhard-Key, Eidherr, Harald, Wiesner, Karoline, Viernstein, Helmut, Kletter, Kurt, Dudczak, Robert

“…Introduction. Although the first polyphosphonates were already introduced in the early 1970s, mechanisms involved in uptake still remain speculative. The…”
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In vitro evaluation of no carrier added, carrier added and cross-complexed [ 90Y]-EDTMP provides evidence for a novel “foreign carrier theory” by Toegel, Stefan, Mien, Leonhard-Key, Wadsak, Wolfgang, Eidherr, Harald, Viernstein, Helmut, Kluger, Rainer, Ettlinger, Dagmar, Kletter, Kurt, Dudczak, Robert, Mitterhauser, Markus

“…The present study focused on the preparation of novel bone tracers containing yttrium as radionuclide or carrier. Moreover, these preparations were…”
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NCA nucleophilic radiofluorination on substituted benzaldehydes for the preparation of [18F]fluorinated aromatic amino acids by Wadsak, Wolfgang, Wirl-Sagadin, Barbara, Mitterhauser, Markus, Mien, Leonhard-Key, Ettlinger, Dagmar E., Keppler, Bernhard K., Dudczak, Robert, Kletter, Kurt

“…Nucleophilic aromatic substitution is a challenging task in radiochemistry. Therefore, a thorough evaluation and optimisation of this step is needed to provide…”
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Radiosynthesis of 3-(2′-[18F]fluoro)-flumazenil ([18F]FFMZ) by Wadsak, Wolfgang, Mitterhauser, Markus, Mien, Leonhard-Key, Tögel, Stefan, Keppler, Bernhard, Dudczak, Robert, Kletter, Kurt

“…Recently, two fluorine‐18 labelled derivatives of flumazenil were described: 5‐(2′‐[18F]fluoroethyl)‐5‐desmethylflumazenil (ethyl…”
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