Search Results - "Miele, Gino"

Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain-dependent manner by Kranich, Jan, Krautler, Nike Julia, Falsig, Jeppe, Ballmer, Boris, Li, Shulei, Hutter, Gregor, Schwarz, Petra, Moos, Rita, Julius, Christian, Miele, Gino, Aguzzi, Adriano

“…Progressive accumulation of PrP(Sc), a hallmark of prion diseases, occurs when conversion of PrP(C) into PrP(Sc) is faster than PrP(Sc) clearance. Engulfment…”
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Comparative gene expression profiling identifies common molecular signatures of NF-κB activation in canine and human diffuse large B cell lymphoma (DLBCL) by Mudaliar, Manikhandan A V, Haggart, Ross D, Miele, Gino, Sellar, Grant, Tan, Karen A L, Goodlad, John R, Milne, Elspeth, Vail, David M, Kurzman, Ilene, Crowther, Daniel, Argyle, David J

“…We present the first comparison of global transcriptional changes in canine and human diffuse large B-cell lymphoma (DLBCL), with particular reference to the…”
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Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8 by Kranich, Jan, Krautler, Nike Julia, Heinen, Ernst, Polymenidou, Magdalini, Bridel, Claire, Schildknecht, Anita, Huber, Christoph, Kosco-Vilbois, Marie H, Zinkernagel, Rolf, Miele, Gino, Aguzzi, Adriano

“…The secreted phosphatidylserine-binding protein milk fat globule epidermal growth factor 8 (Mfge8) mediates engulfment of apoptotic germinal center B cells by…”
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Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: Relationship to disease severity by Chaudhuri, Rekha, MD, McSharry, Charles, PhD, Brady, Jeffrey, PhD, Donnelly, Iona, BSc, Grierson, Christal, PhD, McGuinness, Stephen, BSc, Jolly, Lisa, BSc, Weir, Christopher J., PhD, Messow, C. Martina, PhD, Spears, Mark, PhD, Miele, Gino, PhD, Nocka, Karl, PhD, Crowther, Dan, PhD, Thompson, Joyce, BSc, Brannigan, Maureen, BSc, Lafferty, Jane, BSc, Sproule, Michael, MBChB, MacNee, William, MD, Connell, Martin, BSc, Murchison, John T., FRCR, Shepherd, Malcolm C., PhD, Feuerstein, Giora, MD, Miller, Douglas K., PhD, Thomson, Neil C., MD

“…Background Matrix metalloproteinase (MMP)-12 has been implicated in the pathogenesis of both chronic obstructive pulmonary disease (COPD) and asthma. The…”
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An in vitro diagnostic certified point of care single nucleotide test for IL28B polymorphisms by Duffy, Darragh, Mottez, Estelle, Ainsworth, Shaun, Buivan, Tan-Phuc, Baudin, Aurelie, Vray, Muriel, Reed, Ben, Fontanet, Arnaud, Rohel, Alexandra, Petrov-Sanchez, Ventzislava, Abel, Laurent, Theodorou, Ioannis, Miele, Gino, Pol, Stanislas, Albert, Matthew L

“…Numerous genetic polymorphisms have been identified as associated with disease or treatment outcome, but the routine implementation of genotyping into…”
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Pharmacogenetics to Avoid Loss of Hearing (PALOH) trial: a protocol for a prospective observational implementation trial by McDermott, John Henry, Mahood, Rachel, Stoddard, Duncan, Mahaveer, Ajit, Turner, Mark A, Corry, Rachel, Garlick, Julia, Miele, Gino, Ainsworth, Shaun, Kemp, Laura, Bruce, Iain, Body, Richard, Ulph, Fiona, Macleod, Rhona, Harvey, Karen, Booth, Nicola, Roberts, Peter, Wilson, Paul, Newman, William G

“…IntroductionIn conjunction with a beta-lactam, aminoglycosides are the first-choice antibiotic for empirical treatment of sepsis in the neonatal period. The…”
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Cystatin F is a biomarker of prion pathogenesis in mice by Nuvolone, Mario, Schmid, Nicolas, Miele, Gino, Sorce, Silvia, Moos, Rita, Schori, Christian, Beerli, Roger R, Bauer, Monika, Saudan, Philippe, Dietmeier, Klaus, Lachmann, Ingolf, Linnebank, Michael, Martin, Roland, Kallweit, Ulf, Kana, Veronika, Rushing, Elisabeth J, Budka, Herbert, Aguzzi, Adriano

“…Misfolding of the cellular prion protein (PrPC) into the scrapie prion protein (PrPSc) results in progressive, fatal, transmissible neurodegenerative…”
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Liposome-siRNA-peptide complexes cross the blood-brain barrier and significantly decrease PrP on neuronal cells and PrP in infected cell cultures by Pulford, Bruce, Reim, Natalia, Bell, Aimee, Veatch, Jessica, Forster, Genevieve, Bender, Heather, Meyerett, Crystal, Hafeman, Scott, Michel, Brady, Johnson, Theodore, Wyckoff, A Christy, Miele, Gino, Julius, Christian, Kranich, Jan, Schenkel, Alan, Dow, Steven, Zabel, Mark D

“…Recent advances toward an effective therapy for prion diseases employ RNA interference to suppress PrP(C) expression and subsequent prion neuropathology,…”
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Diagnosing and Preventing Hearing Loss in the Genomic Age by McDermott, John H., Molina-Ramírez, Leslie P, Bruce, Iain A, Mahaveer, Ajit, Turner, Mark, Miele, Gino, Body, Richard, Mahood, Rachel, Ulph, Fiona, MacLeod, Rhona, Harvey, Karen, Booth, Nicola, Demain, Leigh A. M., Wilson, Paul, Black, Graeme C., Morton, Cynthia C., Newman, William G

“…Over the past two decades, significant technological advances have facilitated the identification of hundreds of genes associated with hearing loss. Variants…”
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Liposome-siRNA-Peptide Complexes Cross the Blood-Brain Barrier and Significantly Decrease PrPC on Neuronal Cells and PrPRES in Infected Cell Cultures by Pulford, Bruce, Reim, Natalia, Bell, Aimee, Veatch, Jessica, Forster, Genevieve, Bender, Heather, Meyerett, Crystal, Hafeman, Scott, Michel, Brady, Johnson, Theodore, Wyckoff, A. Christy, Miele, Gino, Julius, Christian, Kranich, Jan, Schenkel, Alan, Dow, Steven, Zabel, Mark D.

“…Background Recent advances toward an effective therapy for prion diseases employ RNA interference to suppress PrPC expression and subsequent prion…”
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Coincident Scrapie Infection and Nephritis Lead to Urinary Prion Excretion by Seeger, Harald, Heikenwalder, Mathias, Zeller, Nicolas, Kranich, Jan, Schwarz, Petra, Gaspert, Ariana, Seifert, Burkhardt, Miete, Gino, Aguzzi, Adriano

“…Prion infectivity is typically restricted to the central nervous and lymphatic systems of infected hosts, but chronic inflammation can expand the distribution…”
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A novel erythroid-specific marker of transmissible spongiform encephalopathies by Clinton, Michael, Miele, Gino, Manson, Jean

“…Transmissible spongiform encephalopathies (TSE) are a group of invariably fatal neurodegenerative diseases and include scrapie in sheep, bovine spongiform…”
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Simultaneous non-negative matrix factorization for multiple large scale gene expression datasets in toxicology by Lee, Clare M, Mudaliar, Manikhandan A V, Haggart, D R, Wolf, C Roland, Miele, Gino, Vass, J Keith, Higham, Desmond J, Crowther, Daniel

“…Non-negative matrix factorization is a useful tool for reducing the dimension of large datasets. This work considers simultaneous non-negative matrix…”
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Truncated Prion Protein and Doppel Are Myelinotoxic in the Absence of Oligodendrocytic PrPC by Radovanovic, Ivan, Braun, Nathalie, Giger, Olivier T, Mertz, Kirsten, Miele, Gino, Prinz, Marco, Navarro, Beatriz, Aguzzi, Adriano

“…The cellular prion protein PrP(C) confers susceptibility to transmissible spongiform encephalopathies, yet its normal function is unknown. Although…”
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Urinary α1-Antichymotrypsin: A Biomarker of Prion Infection by Miele, Gino, Seeger, Harald, Marino, Denis, Eberhard, Ralf, Heikenwalder, Mathias, Stoeck, Katharina, Basagni, Max, Knight, Richard, Green, Alison, Chianini, Francesca, Wüthrich, Rudolf P., Hock, Christoph, Zerr, Inga, Aguzzi, Adriano

“…The occurrence of blood-borne prion transmission incidents calls for identification of potential prion carriers. However, current methods for intravital…”
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Humoral Immune Response to Native Eukaryotic Prion Protein Correlates with Anti-Prion Protection by Polymenidou, Magdalini, Heppner, Frank L., Pellicioli, Erica C., Urich, Eduard, Miele, Gino, Braun, Nathalie, Wopfner, Franziska, Schätzl, Hermann M., Becher, Burkhard, Aguzzi, Adriano

“…Prion diseases are characterized by the deposition of an abnormal form (termed PrP Sc) of the cellular prion protein ( PrP C). Because antibodies to PrP C can…”
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Global array-based transcriptomics from minimal input RNA utilising an optimal RNA isolation process combined with SPIA cDNA probes by Kennedy, Laura, Pauriah, Mahesh, Godfrey, Valerie, Howie, Jacqueline, Dennis, Helen, Crowther, Daniel, Struthers, Allan, Goddard, Catharine, Feuerstein, Giora, Lang, Chim, Miele, Gino

“…Technical advances in the collection of clinical material, such as laser capture microdissection and cell sorting, provide the advantage of yielding more…”
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Disruption of Doppel Prevents Neurodegeneration in Mice with Extensive Prnp Deletions by Genoud, Nicolas, Behrens, Axel, Miele, Gino, Robay, Dimitri, Heppner, Frank L., Freigang, Stefan, Aguzzi, Adriano, Weissmann, Charles

“…The Prnp gene encodes the cellular prion protein PrPC. Removal of its ORF does not result in pathological phenotypes, but deletions extending into the upstream…”
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Functional Analysis of the Core Human Immunodeficiency Virus Type 1 Packaging Signal in a Permissive Cell Line by Harrison, G P, Miele, G, Hunter, E, Lever, A M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Hematopoietic Lineage Transcriptome Stability and Representation in PAXgene™ Collected Peripheral Blood Utilising SPIA Single-Stranded cDNA Probes for Microarray by Kennedy, Laura, Vass, J. Keith, Haggart, D. Ross, Moore, Steve, Burczynski, Michael E., Crowther, Dan, Miele, Gino

“…Peripheral blood as a surrogate tissue for transcriptome profiling holds great promise for the discovery of diagnostic and prognostic disease biomarkers,…”
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