Preparation of Budesonide-Loaded Polycaprolactone Nanobeads by Electrospraying for Controlled Drug Release

Corticosteroids such as budesonide are the drugs of choice for the treatment of inflammatory disorders with an inherent limitation, viz., rapid elimination. To overcome this constraint and attain sustained release, budesonide was encapsulated in a biodegradable polymer, polycaprolactone (PCL), by DC...

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Bibliographic Details
Published in:	Journal of biomaterials science. Polymer ed. Vol. 22; no. 18; pp. 2431 - 2444
Main Authors:	Midhun, B. T., Shalumon, K. T., Manzoor, K., Jayakumar, R., Nair, S. V., Deepthy, M.
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis Group 01-01-2011
Subjects:	BUDESONIDE Budesonide - administration & dosage Budesonide - chemistry Budesonide - pharmacokinetics Cell Survival CONTROLLED DRUG DELIVERY Controllers Delayed-Action Preparations - chemical synthesis Delayed-Action Preparations - chemistry Drug Carriers - chemical synthesis Drug Carriers - chemistry Drug Liberation Drugs Electric Conductivity ELECTROSPRAYING Encapsulation Glucocorticoids - administration & dosage Glucocorticoids - chemistry Glucocorticoids - pharmacokinetics Humans Materials Testing MCF-7 Cells Microscopy, Electron, Scanning NANOBEADS Nanocomposites Nanofibers - chemistry Nanomaterials Nanoparticles - chemistry Nanoparticles - ultrastructure Nanostructure Particle Size POLY(CAPROLACTONE) Polyesters - chemistry Programmable logic devices Solutions Spectroscopy, Fourier Transform Infrared Suspensions Viscosity Water - chemistry BUDESONIDE CONTROLLED DRUG DELIVERY ELECTROSPRAYING NANOBEADS POLY(CAPROLACTONE)
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Summary:	Corticosteroids such as budesonide are the drugs of choice for the treatment of inflammatory disorders with an inherent limitation, viz., rapid elimination. To overcome this constraint and attain sustained release, budesonide was encapsulated in a biodegradable polymer, polycaprolactone (PCL), by DC electrospraying. By varying the experimental parameters involved in electrospraying such as applied voltage, flow rate, viscosity as well as conductivity of the polymer solution, the dimensionality of nanostructures was tuned from 1-D nanofibers to spherical nanoparticles. By adopting this rapid and viable method of DC electrospraying, we successfully prepared aqueous suspensions of nearly monodispersed, nano-sized drug encapsulated PCL. Drug encapsulation efficiency, in vitro drug release as well as biocompatibility studies of budesonide-loaded PCL nanobeads were carried out. The cytocompatible nanobeads prepared by electrospraying exhibited good encapsulation efficiency (approx. 75%), with controlled drug release enabled by the dissolution of the polymer. Our results demonstrate the potential of this novel technique of electrospraying in developing efficient drug encapsulated polymeric nanocarriers possessing sustained drug release profile.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0920-5063 1568-5624
DOI:	10.1163/092050610X540486