Search Results - "Midha, Rajiv"

Nerve transfers for severe brachial plexus injuries: a review by Midha, Rajiv

“…Nerve transfer procedures are increasingly performed for repair of severe brachial plexus injury (BPI), in which the proximal spinal nerve roots have been…”
Get full text

Macrophages Regulate Schwann Cell Maturation after Nerve Injury by Stratton, Jo Anne, Holmes, Alexandra, Rosin, Nicole L., Sinha, Sarthak, Vohra, Mohit, Burma, Nicole E., Trang, Tuan, Midha, Rajiv, Biernaskie, Jeff

“…Pro-regenerative macrophages are well known for their role in promoting tissue repair; however, their specific roles in promoting regeneration of the injured…”
Get full text

Insights Into the Role and Potential of Schwann Cells for Peripheral Nerve Repair From Studies of Development and Injury by Balakrishnan, Anjali, Belfiore, Lauren, Chu, Tak-Ho, Fleming, Taylor, Midha, Rajiv, Biernaskie, Jeff, Schuurmans, Carol

“…Peripheral nerve injuries arising from trauma or disease can lead to sensory and motor deficits and neuropathic pain. Despite the purported ability of the…”
Get full text

Nerve Guidance Tubes (Conduits): Past, Present and Future by Midha, Rajiv, M.D., FRCSC, FAANS

Get full text

A Multi-Stage Bioprocess for the Expansion of Rodent Skin-Derived Schwann Cells in Computer-Controlled Bioreactors by Walsh, Tylor, Abraham, Brett, Chu, Tak-Ho, Biernaskie, Jeff, Midha, Rajiv, Kallos, Michael S

“…Regenerative therapies for the treatment of peripheral nerve and spinal cord injuries can require hundreds of millions of autologous cells. Current treatments…”
Get full text

Skin derived precursor Schwann cells improve behavioral recovery for acute and delayed nerve repair by Khuong, Helene T., Kumar, Ranjan, Senjaya, Ferry, Grochmal, Joey, Ivanovic, Aleksandra, Shakhbazau, Antos, Forden, Joanne, Webb, Aubrey, Biernaskie, Jeffrey, Midha, Rajiv

“…Previous work has shown that infusion of skin-derived precursors pre-differentiated into Schwann cells (SKP-SCs) can remyelinate injured and regenerating…”
Get full text

Analysis of the effect of intraoperative neuromonitoring during resection of benign nerve sheath tumors on gross-total resection and neurological complications by Wilson, Thomas J, Hamrick, Forrest, Alzahrani, Saud, Dibble, Christopher F, Koduri, Sravanthi, Pendleton, Courtney, Saleh, Sara, Ali, Zarina S, Mahan, Mark A, Midha, Rajiv, Ray, Wilson Z, Yang, Lynda J S, Zager, Eric L, Spinner, Robert J

“…The aim of this study was to examine the role of intraoperative neuromonitoring (IONM) during resection of benign peripheral nerve sheath tumors in achieving…”
Get full text

Dose and duration of nerve growth factor (NGF) administration determine the extent of behavioral recovery following peripheral nerve injury in the rat by Kemp, Stephen W.P., Webb, Aubrey A., Dhaliwal, Sundeep, Syed, Shahbaz, Walsh, Sarah K., Midha, Rajiv

“…Nerve growth factor (NGF) has been previously shown to support neuron survival and direct neurite outgrowth in vitro, and to enhance axonal regeneration in…”
Get full text

The immunomodulatory properties of adult skin-derived precursor Schwann cells: implications for peripheral nerve injury therapy by Stratton, Jo Anne, Shah, Prajay T., Kumar, Ranjan, Stykel, Morgan G., Shapira, Yuval, Grochmal, Joey, Guo, Gui Fang, Biernaskie, Jeff, Midha, Rajiv

“…Skin‐derived precursor Schwann cell (SKPSC) therapy has been identified as a potentially beneficial treatment for peripheral nerve injuries. One hypothesised…”
Get full text

Accelerated axon outgrowth, guidance, and target reinnervation across nerve transection gaps following a brief electrical stimulation paradigm by Singh, Bhagat, Xu, Qing-Gui, Franz, Colin K, Zhang, Rumi, Dalton, Colin, Gordon, Tessa, Verge, Valerie M K, Midha, Rajiv, Zochodne, Douglas W

“…Regeneration of peripheral nerves is remarkably restrained across transection injuries, limiting recovery of function. Strategies to reverse this common and…”
Get full text

Overcoming neurite-inhibitory chondroitin sulfate proteoglycans in the astrocyte matrix by Cua, Rowena C., Lau, Lorraine W., Keough, Michael B., Midha, Rajiv, Apte, Suneel S., Yong, V. Wee

“…Acute trauma to the central nervous system (CNS) can result in permanent damage and loss of function related to the poor regeneration of injured axons. Injured…”
Get full text

Doxycycline-regulated GDNF expression promotes axonal regeneration and functional recovery in transected peripheral nerve by Shakhbazau, Antos, Mohanty, Chandan, Shcharbin, Dzmitry, Bryszewska, Maria, Caminade, Anne-Marie, Majoral, Jean-Pierre, Alant, Jacob, Midha, Rajiv

“…Increased production of neurotrophic factors (NTFs) is one of the key responses seen following peripheral nerve injury, making them an attractive choice for…”
Get full text

Macrophages and Associated Ligands in the Aged Injured Nerve: A Defective Dynamic That Contributes to Reduced Axonal Regrowth by Stratton, Jo Anne, Eaton, Shane, Rosin, Nicole L., Jawad, Sana, Holmes, Alexandra, Yoon, Grace, Midha, Rajiv, Biernaskie, Jeff

“…Regenerative capacity of injured peripheral nerves is diminished with aging. To identify factors that contribute to this impairment, we compared the immune…”
Get full text

Recent advances in stem cell-mediated peripheral nerve repair by Grochmal, Joey, Midha, Rajiv

“…A major advance in the field of peripheral nerve repair has been the advent of stem and progenitor cell use to supplement the regenerative environment in…”
Get more information

Adult skin-derived precursor Schwann cells exhibit superior myelination and regeneration supportive properties compared to chronically denervated nerve-derived Schwann cells by Kumar, Ranjan, Sinha, Sarthak, Hagner, Andrew, Stykel, Morgan, Raharjo, Eko, Singh, Karun K., Midha, Rajiv, Biernaskie, Jeff

“…Functional outcomes following delayed peripheral nerve repair are poor. Schwann cells (SCs) play key roles in supporting axonal regeneration and remyelination…”
Get full text

The impact of motor axon misdirection and attrition on behavioral deficit following experimental nerve injuries by Alant, Jacob Daniel de Villiers, Senjaya, Ferry, Ivanovic, Aleksandra, Forden, Joanne, Shakhbazau, Antos, Midha, Rajiv

“…Peripheral nerve transection and neuroma-in-continuity injuries are associated with permanent functional deficits, often despite successful end-organ…”
Get full text

Malignant Peripheral Nerve Sheath Tumors by Khu, Kathleen Joy, MD, Midha, Rajiv, MD, MSc, FRCSC, FAANS

“…Highlights • Malignant peripheral nerve sheath tumors are rare and aggressive tumors that arise from a peripheral nerve or show nerve sheath differentiation on…”
Get full text

Purification and Characterization of Schwann Cells from Adult Human Skin and Nerve by Stratton, Jo Anne, Kumar, Ranjan, Sinha, Sarthak, Shah, Prajay, Stykel, Morgan, Shapira, Yuval, Midha, Rajiv, Biernaskie, Jeff

“…Despite its modest capacity for regeneration, peripheral nervous system injury often results in significant long-term disability. Supplementing peripheral…”
Get full text

Control of dissolved oxygen significantly increases the yield of skin‐derived Schwann cells during expansion in stirred suspension bioreactors by Walsh, Tylor, Biernaskie, Jeff, Midha, Rajiv, Kallos, Michael S.

“…Peripheral nerve and spinal cord injuries affect millions of people worldwide often leading to lifelong disability and pain. Cell therapy using autologous…”
Get full text

Functional Gait Assessment Using Manual, Semi-Automated and Deep Learning Approaches Following Standardized Models of Peripheral Nerve Injury in Mice by Umansky, Daniel, Hagen, Kathleen M, Chu, Tak Ho, Pathiyil, Rajesh K, Alzahrani, Saud, Ousman, Shalina S, Midha, Rajiv

“…Objective: To develop a standardized model of stretch−crush sciatic nerve injury in mice, and to compare outcomes of crush and novel stretch−crush injuries…”
Get full text