Search Results - "Midgley, R."

The proportion of tumor-stroma as a strong prognosticator for stage II and III colon cancer patients: validation in the VICTOR trial by Huijbers, A., Tollenaar, R.A.E.M., v Pelt, G.W., Zeestraten, E.C.M., Dutton, S., McConkey, C.C., Domingo, E., Smit, V.T.H.B.M., Midgley, R., Warren, B.F., Johnstone, E.C., Kerr, D.J., Mesker, W.E.

“…The intra-tumor stroma percentage in colon cancer (CC) patients has previously been reported by our group as a strong independent prognostic parameter…”
Get full text

Colorectal cancer by Midgley, R, Kerr, D

“…Colorectal cancer is a leading cause of morbidity and mortality with about 300 000 new cases and 200 000 deaths in Europe and the USA each year. 1,2 Published…”
Get full text

TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres by Jones, A M, Beggs, A D, Carvajal-Carmona, L, Farrington, S, Tenesa, A, Walker, M, Howarth, K, Ballereau, S, Hodgson, S V, Zauber, A, Bertagnolli, M, Midgley, R, Campbell, H, Kerr, D, Dunlop, M G, Tomlinson, I P M

“…Shorter telomeres have been associated with increased risk of malignancy, including colorectal cancer (CRC). Telomere length is heritable and may be an…”
Get more information

A phase I and pharmacokinetic study of lapatinib in combination with infusional 5-fluorouracil, leucovorin and irinotecan by Midgley, R.S., Kerr, D.J., Flaherty, K.T., Stevenson, J.P., Pratap, S.E., Koch, K.M., Smith, D.A., Versola, M., Fleming, R.A., Ward, C., O'Dwyer, P.J., Middleton, M.R.

“…This study determined the optimally tolerated regimen (OTR) of oral lapatinib administered in combination with infusional 5-fluorouracil (5-FU), leucovorin and…”
Get full text

Safety, tolerability, pharmacokinetics and pharmacodynamics of the oral cyclin-dependent kinase inhibitor AZD5438 when administered at intermittent and continuous dosing schedules in patients with advanced solid tumours by Boss, D.S., Schwartz, G.K., Middleton, M.R., Amakye, D.D., Swaisland, H., Midgley, R.S., Ranson, M., Danson, S., Calvert, H., Plummer, R., Morris, C., Carvajal, R.D., Chirieac, L.R., Schellens, J.H.M., Shapiro, G.I.

“…AZD5438 is an orally bioavailable inhibitor of cyclin E-cdk2, cyclin A-cdk2 and cyclin B-cdk1 complexes. Three phase I studies assessed the clinical safety,…”
Get full text

A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer by Khan, O A, Ranson, M, Michael, M, Olver, I, Levitt, N C, Mortimer, P, Watson, A J, Margison, G P, Midgley, R, Middleton, M R

“…To evaluate the tumour response to lomeguatrib and temozolomide (TMZ) administered for 5 consecutive days every 4 weeks in patients with metastatic colorectal…”
Get full text

phase I trial of lomeguatrib and irinotecan in metastatic colorectal cancer by Sabharwal, A, Corrie, P. G, Midgley, R. S, Palmer, C, Brady, J, Mortimer, P, Watson, A. J, Margison, G. P, Middleton, M. R

“…Background Expression of the DNA repair protein O ⁶-methylguanine-DNA methyltransferase (MGMT) correlates with resistance to irinotecan in colorectal cancer…”
Get full text

Systemic treatment of colorectal cancer by Tebbutt, N.C, Cattell, E, Midgley, R, Cunningham, D, Kerr, D

“…Palliative and adjuvant treatment for colorectal cancer has been, until recently, largely dependent on 5-fluorouracil (5-FU)-based chemotherapy. Oral…”
Get full text

PP 104 Stroma production within the primary tumor correlates with poor survival for stage I-II colon cancer patients by Mesker, W, Huijbers, A, Johnstone, E, van Pelt, G, Midgley, R, Morreau, H, Kerr, D, Tollenaar, R

Get full text

6082 POSTER Stroma Production Within the Primary Tumour Correlates With Poor Survival for Stage l-ll Colon Cancer Patients by Mesker, W.E, Huijbers, A, Johnstone, E.C, Van Pelt, G.W, Midgley, R, Liefers, G.J, Morreau, J, Kerr, D.J, Tollenaar, R.A.E.M

Get full text

Latent Gene Sequencing Reveals Familial Relationships among Chinese Epstein-Barr Virus Strains and Evidence for Positive Selection of A11 Epitope Changes by Midgley, R S, Bell, A I, McGeoch, D J, Rickinson, A B

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

HLA-A11-Restricted Epitope Polymorphism among Epstein-Barr Virus Strains in the Highly HLA-A11-Positive Chinese Population: Incidence and Immunogenicity of Variant Epitope Sequences by Midgley, R S, Bell, A I, Yao, Q Y, Croom-Carter, D, Hislop, A D, Whitney, B M, Chan, A T C, Johnson, P J, Rickinson, A B

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer by Khan, O A, Ranson, M, Michael, M, Olver, I, Levitt, N C, Mortimer, P, Watson, A J, Margison, G P, Midgley, R, Middleton, M R

Get full text

Conventional cytotoxic and novel therapeutic concepts in colorectal cancer by Midgley, R, Kerr, D

“…Colorectal cancer (CRC) is a major cause of death, particularly in the Western world, leading to 400,000 deaths each year. Of the patients, 30% have advanced…”
Get more information

Novel Intertypic Recombinants of Epstein-Barr Virus in the Chinese Population by Midgley, R S, Blake, N W, Yao, Q Y, Croom-Carter, D, Cheung, S T, Leung, S F, Chan, A T, Johnson, P J, Huang, D, Rickinson, A B, Lee, S P

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Changes in expression of connexin 43 gap junction messenger ribonucleic acid and protein during ovarian follicular growth by Wiesen, J F, Midgley, Jr, A R

“…Within the ovarian follicle, communication between granulosa cells and the oocyte via gap junction channels may be crucial for the determination of whether a…”
Get more information

A two-site chemiluminescent assay for activin-free follistatin reveals that most follistatin circulating in men and normal cycling women is in an activin-bound state by MCCONNELL, D. S, QIFA WANG, SLUSS, P. M, BOLF, N, KHOURY, R. H, SCHNEYER, A. L, MIDGLEY, A. R, REAME, N. E, CROWLEY, W. F, PADMANABHAN, V

“…Follistatin (FS) is a monomeric protein that binds and regulates the bioavailability of activin. Previously, we found circulating levels of total FS to be…”
Get full text

mathematical model of luteinizing hormone release from ovine pituitary cells in perifusion by Heinze, K, Keener, R.W, Midgley, A.R. Jr

“…We model the effect of gonadotropin-releasing hormone (GnRH) on the production of luteinizing hormone (LH) by the ovine pituitary. GnRH, released by the…”
Get full text

Circulating concentrations of dimeric inhibin A and B in the male rhesus monkey (Macaca mulatta) by PLANT, T. M, PADMANABHAN, V, RAMASWAMY, S, MCCONNELL, D. S, WINTERS, S. J, GROOME, N, MIDGLEY, A. R, MCNEILLY, A. S

“…The purpose of this study was to determine the relative concentrations of inhibin A and B in peripheral serum of the adult male rhesus monkey and to examine…”
Get full text

127 Stroma production within the primary tumour correlates with poor survival for stage I-II colon cancer patients by Mesker, W.E, Johnstone, E.C, Van Pelt, G.W, Midgley, R, Liefers, G.J, Morreau, J, Kerr, D.J, Tollenaar, R.A.E.M

Get full text