Search Results - "Middleton, David"

Improving descriptive terminology using a descriptive algorithm as an educational intervention to improve referral accuracy by Middleton, David W, Dolan, Olivia

“…The accuracy of clinical communication in referrals to dermatology has not been fully explored. Baseline analysis of inpatient ward referral to a dermatology…”
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Sensitive Morphological Characterization of Oriented High-Density Lipoprotein Nanoparticles Using 31 P NMR Spectroscopy by Lau, Sophie, Middleton, David A

“…The biological function of high-density lipoprotein (HDL) nanoparticles, the so-called good cholesterol that is associated with a low risk of heart disease,…”
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Sensitive Morphological Characterization of Oriented High‐Density Lipoprotein Nanoparticles Using 31P NMR Spectroscopy by Lau, Sophie, Middleton, David A.

“…The biological function of high‐density lipoprotein (HDL) nanoparticles, the so‐called good cholesterol that is associated with a low risk of heart disease,…”
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Solid-state NMR chemical shift analysis for determining the conformation of ATP bound to Na,K-ATPase in its native membrane by Middleton, David A, Griffin, John, Esmann, Mikael, Fedosova, Natalya U

“…Structures of membrane proteins determined by X-ray crystallography and, increasingly, by cryo-electron microscopy often fail to resolve the structural details…”
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Raman Spectroscopy with 2D Perturbation Correlation Moving Windows for the Characterization of Heparin-Amyloid Interactions by Townsend, David J, Middleton, David A, Ashton, Lorna

“…It has been shown extensively that glycosaminoglycan (GAG)-protein interactions can induce, accelerate, and impede the clearance of amyloid fibrils associated…”
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Aggregation Kinetics and Filament Structure of a Tau Fragment Are Influenced by the Sulfation Pattern of the Cofactor Heparin by Townsend, David, Fullwood, Nigel J, Yates, Edwin A, Middleton, David A

“…A pathological signature of Alzheimer's disease (AD) is the formation of neurofibrillary tangles comprising filamentous aggregates of the microtubule…”
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New Guinea has the world’s richest island flora by Cámara-Leret, Rodrigo, Frodin, David G., Adema, Frits, Anderson, Christiane, Appelhans, Marc S., Argent, George, Arias Guerrero, Susana, Ashton, Peter, Baker, William J., Barfod, Anders S., Barrington, David, Borosova, Renata, Bramley, Gemma L. C., Briggs, Marie, Buerki, Sven, Cahen, Daniel, Callmander, Martin W., Cheek, Martin, Chen, Cheng-Wei, Conn, Barry J., Coode, Mark J. E., Darbyshire, Iain, Dawson, Sally, Dransfield, John, Drinkell, Clare, Duyfjes, Brigitta, Ebihara, Atsushi, Ezedin, Zacky, Fu, Long-Fei, Gideon, Osia, Girmansyah, Deden, Govaerts, Rafaël, Fortune-Hopkins, Helen, Hassemer, Gustavo, Hay, Alistair, Heatubun, Charlie D., Hind, D. J. Nicholas, Hoch, Peter, Homot, Peter, Hovenkamp, Peter, Hughes, Mark, Jebb, Matthew, Jennings, Laura, Jimbo, Tiberius, Kessler, Michael, Kiew, Ruth, Knapp, Sandra, Lamei, Penniel, Lehnert, Marcus, Lewis, Gwilym P., Linder, Hans Peter, Lindsay, Stuart, Low, Yee Wen, Lucas, Eve, Mancera, Jeffrey P., Monro, Alexandre K., Moore, Alison, Middleton, David J., Nagamasu, Hidetoshi, Newman, Mark F., Nic Lughadha, Eimear, Melo, Pablo H. A., Ohlsen, Daniel J., Pannell, Caroline M., Parris, Barbara, Pearce, Laura, Penneys, Darin S., Perrie, Leon R., Petoe, Peter, Poulsen, Axel Dalberg, Prance, Ghillean T., Quakenbush, J. Peter, Raes, Niels, Rodda, Michele, Rogers, Zachary S., Schuiteman, André, Schwartsburd, Pedro, Scotland, Robert W., Simmons, Mark P., Simpson, David A., Stevens, Peter, Sundue, Michael, Testo, Weston, Trias-Blasi, Anna, Turner, Ian, Utteridge, Timothy, Walsingham, Lesley, Webber, Bruce L., Wei, Ran, Weiblen, George D., Weigend, Maximilian, Weston, Peter, de Wilde, Willem, Wilkie, Peter, Wilmot-Dear, Christine M., Wilson, Hannah P., Wood, John R. I., Zhang, Li-Bing, van Welzen, Peter C.

“…New Guinea is the world’s largest tropical island and has fascinated naturalists for centuries 1 , 2 . Home to some of the best-preserved ecosystems on the…”
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Insights into the Molecular Architecture of a Peptide Nanotube Using FTIR and Solid-State NMR Spectroscopic Measurements on an Aligned Sample by Middleton, David A., Madine, Jillian, Castelletto, Valeria, Hamley, Ian W.

“…Queuing up: Molecular orientation within macroscopically aligned nanotubes of the peptide AAAAAAK can be studied by solid‐state NMR and IR spectroscopy. Line…”
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Comparison of the structure and function of phospholamban and the arginine-14 deficient mutant associated with dilated cardiomyopathy by Hughes, Eleri, Middleton, David A

“…Phospholamban (PLB) is a pentameric protein that plays an important role in regulating cardiac contractility via a reversible inhibitory association with the…”
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Heparin and Methionine Oxidation Promote the Formation of Apolipoprotein A‑I Amyloid Comprising α‑Helical and β‑Sheet Structures by Townsend, David, Hughes, Eleri, Hussain, Rohanah, Siligardi, Giuliano, Baldock, Sarah, Madine, Jillian, Middleton, David A

“…Peptides derived from apolipoprotein A-I (apoA-I), the main component of high-density lipoprotein (HDL), constitute the main component of amyloid deposits that…”
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Drug orientations within statin-loaded lipoprotein nanoparticles by 19 F solid-state NMR by Lau, Sophie, Stanhope, Naomi, Griffin, John, Hughes, Eleri, Middleton, David A

“…NMR measurements of 19F chemical shift anisotropy and 1H-19F dipolar couplings provide unprecedented information on the molecular orientations of two…”
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Epigallocatechin-3-gallate remodels apolipoprotein A-I amyloid fibrils into soluble oligomers in the presence of heparin by Townsend, David, Hughes, Eleri, Akien, Geoffrey, Stewart, Katie L., Radford, Sheena E., Rochester, David, Middleton, David A.

“…Amyloid deposits of WT apolipoprotein A-I (apoA-I), the main protein component of high-density lipoprotein, accumulate in atherosclerotic plaques where they…”
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Structural Insights into the Polymorphism of Amyloid-Like Fibrils Formed by Region 20−29 of Amylin Revealed by Solid-State NMR and X-ray Fiber Diffraction by Madine, Jillian, Jack, Edward, Stockley, Peter G, Radford, Sheena E, Serpell, Louise C, Middleton, David A

“…Many unrelated proteins and peptides can assemble into amyloid or amyloid-like nanostructures, all of which share the cross-β motif of repeat arrays of…”
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19 F Solid-State NMR and Vibrational Raman Characterization of Corticosteroid Drug-Lipid Membrane Interactions by Mapley, Bethany, Townsend, David, Griffin, John, Ashton, Lorna, Middleton, David A

“…Drug interactions with phospholipid bilayers underpin their behaviour in cell membranes and in liposomal delivery formulations. Liposomal drug delivery in…”
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19F Solid‐State NMR and Vibrational Raman Characterization of Corticosteroid Drug‐Lipid Membrane Interactions by Mapley, Bethany, Townsend, David, Griffin, John, Ashton, Lorna, Middleton, David A.

“…Drug interactions with phospholipid bilayers underpin their behaviour in cell membranes and in liposomal delivery formulations. Liposomal drug delivery in…”
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Molecular Origins of the Compatibility between Glycosaminoglycans and Aβ40 Amyloid Fibrils by Stewart, Katie L., Hughes, Eleri, Yates, Edwin A., Middleton, David A., Radford, Sheena E.

“…The Aβ peptide forms extracellular plaques associated with Alzheimer's disease. In addition to protein fibrils, amyloid plaques also contain non-proteinaceous…”
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Amyloid-Derived Peptide Forms Self-Assembled Monolayers on Gold Nanoparticle with a Curvature-Dependent β-Sheet Structure by Shaw, Christopher P, Middleton, David A, Volk, Martin, Lévy, Raphaël

“…Using a combination of Fourier transform infrared (FTIR) spectroscopy and solid-state nuclear magnetic resonance (SSNMR) techniques, the secondary structure of…”
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Design of an N-Methylated Peptide Inhibitor of α-Synuclein Aggregation Guided by Solid-State NMR by Madine, Jillian, Doig, Andrew J, Middleton, David A

“…Many neurodegenerative diseases are associated with the aggregation of misfolded proteins into amyloid oligomers or fibrils that are deposited as pathological…”
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Comparisons with Amyloid-β Reveal an Aspartate Residue That Stabilizes Fibrils of the Aortic Amyloid Peptide Medin by Davies, Hannah A., Madine, Jillian, Middleton, David A.

“…Aortic medial amyloid (AMA) is the most common localized human amyloid, occurring in virtually all of the Caucasian population over the age of 50. The main…”
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Atomic Details of the Interactions of Glycosaminoglycans with Amyloid‑β Fibrils by Stewart, Katie L, Hughes, Eleri, Yates, Edwin A, Akien, Geoffrey R, Huang, Teng-Yi, Lima, Marcelo A, Rudd, Timothy R, Guerrini, Marco, Hung, Shang-Cheng, Radford, Sheena E, Middleton, David A

“…The amyloid plaques associated with Alzheimer’s disease (AD) comprise fibrillar amyloid-β (Aβ) peptides as well as non-protein factors including…”
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