Search Results - "Middleton, Brian J"

Practical use of the regression offset approach for the prediction of in vivo intrinsic clearance from hepatocytes by Sohlenius-Sternbeck, Anna-Karin, Jones, Christopher, Ferguson, Douglas, Middleton, Brian J., Projean, Denis, Floby, Eva, Bylund, Johan, Afzelius, Lovisa

“…Systematic under-prediction of clearance is frequently associated with in vitro kinetic data when extrapolated using physiological scaling factors, appropriate…”
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The histone deacetylase inhibitor UCL67022 has potent activity in multiple myeloma and non‐Hodgkin lymphoma pre‐clinical models by Maharaj, Lenushka, Marson, Charles M., Middleton, Brian J., Rioja, Alf S., Perry, Jackie, Oakervee, Heather, Cavenagh, Jamie, Joel, Simon P., Popat, Rakesh

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Effects of a selection of histone deacetylase inhibitors on mast cell activation and airway and colonic smooth muscle contraction by Assem, El-Sayed K, Peh, Kheng H, Wan, Beatrice Y C, Middleton, Brian J, Dines, Jon, Marson, Charles M

“…Studies of histone deacetylase (HDAC) inhibitors, novel anticancer drugs, in models of autoimmune diseases, asthma, and inflammatory bowel disease suggest that…”
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Identification of in Vitro Folding Conditions for Procathepsin S and Cathepsin S Using Fractional Factorial Screens by Tobbell, Dominique A, Middleton, Brian J, Raines, Stephanie, Needham, Maurice R.C, Taylor, Ian W.F, Beveridge, John Y, Abbott, W.Mark

“…Human procathepsin S and cathepsin S were expressed as inclusion bodies in Escherichia coli. Following solubilization of the inclusion body proteins,…”
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The histone deacetylase inhibitor UCL 67022 has potent activity in multiple myeloma and non‐ H odgkin lymphoma pre‐clinical models by Maharaj, Lenushka, Marson, Charles M., Middleton, Brian J., Rioja, Alf S., Perry, Jackie, Oakervee, Heather, Cavenagh, Jamie, Joel, Simon P., Popat, Rakesh

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Biostatistical methodology in carcinogenicity studies by FAIRWEATHER, W. R, BHATTACHARYYA, A, SOPER, K. A, STALLARD, N, VENTRE, J, WRIGHT, J, CEUPPENS, P. P, HEIMANN, G, HOTHORN, L. A, KODELL, R. L, LIN, K. K, MAGER, H, MIDDLETON, B. J, SLOB, W

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Diurnal variation in the femoral articular cartilage of the knee in young adult humans by Waterton, John C., Solloway, Stuart, Foster, John E., Keen, Michael C., Gandy, Stephen, Middleton, Brian J., Maciewicz, Rose A., Watt, Iain, Dieppe, Paul A., Taylor, Christopher J.

“…Our objective was to test the hypothesis that diurnal changes occur in thickness or volume of the femoral articular cartilage of the knee in asymptomatic young…”
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