Search Results - "Middelberg, Anton P. J"

Nanoparticle vaccines by Zhao, Liang, Seth, Arjun, Wibowo, Nani, Zhao, Chun-Xia, Mitter, Neena, Yu, Chengzhong, Middelberg, Anton P.J

“…Highlights • Nanotechnology offers new vistas for the engineering of vaccine formulations. • Nanoparticles of various size, shape, surface and composition are…”
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Poly-l-lysine Functionalized Large Pore Cubic Mesostructured Silica Nanoparticles as Biocompatible Carriers for Gene Delivery by Hartono, Sandy B, Gu, Wenyi, Kleitz, Freddy, Liu, Jian, He, Lizhong, Middelberg, Anton P. J, Yu, Chengzhong, Lu, Gao Qing (Max), Qiao, Shi Zhang

“…Large pore mesoporous silica nanoparticles (LP-MSNs) functionalized with poly-l-lysine (PLL) were designed as a new carrier material for gene delivery…”
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Molecular Insight into Conformational Transition of Amyloid β-Peptide 42 Inhibited by (−)-Epigallocatechin-3-gallate Probed by Molecular Simulations by Liu, Fu-Feng, Dong, Xiao-Yan, He, Lizhong, Middelberg, Anton P. J, Sun, Yan

“…Considerable experimental evidence indicates that (−)-epigallocatechin-3-gallate (EGCG) inhibits the fibrillogenesis of Aβ42 and alleviates its associated…”
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Biomolecular engineering of virus-like particles aided by computational chemistry methods by Zhang, Lin, Lua, Linda H L, Middelberg, Anton P J, Sun, Yan, Connors, Natalie K

“…Virus-like particles (VLPs) are repetitive organizations of viral proteins assembled in an appropriate physicochemical environment. VLPs can stimulate both…”
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Subcellular compartment targeting of layered double hydroxide nanoparticles by Xu, Zhi Ping, Niebert, Marcus, Porazik, Katharina, Walker, Tara L., Cooper, Helen M., Middelberg, Anton P.J., Gray, Peter P., Bartlett, Perry F., Lu, Gao Qing (Max)

“…Current investigations show that layered double hydroxide (LDH) nanoparticles have high potential as effective non-viral agents for cellular drug delivery due…”
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Reversible active switching of the mechanical properties of a peptide film at a fluid-fluid interface by Middelberg, Anton P. J, Dexter, Annette F, Malcolm, Andrew S

“…Designer peptides have recently been developed as building blocks for novel self-assembled materials with stimuli-responsive properties. To date, such…”
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Understanding the Effects of Nanocapsular Mechanical Property on Passive and Active Tumor Targeting by Hui, Yue, Wibowo, David, Liu, Yun, Ran, Rui, Wang, Hao-Fei, Seth, Arjun, Middelberg, Anton P. J, Zhao, Chun-Xia

“…The physicochemical properties of nanoparticles (size, charge, and surface chemistry, etc.) influence their biological functions often in complex and poorly…”
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Non-carrier nanoparticles adjuvant modular protein vaccine in a particle-dependent manner by Seth, Arjun, Ritchie, Fiona K, Wibowo, Nani, Lua, Linda H L, Middelberg, Anton P J

“…Nanoparticles are increasingly used to adjuvant vaccine formulations due to their biocompatibility, ease of manufacture and the opportunity to tailor their…”
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Immunogenicity of Outer Membrane Proteins VirB9-1 and VirB9-2, a Novel Nanovaccine against Anaplasma marginale by Zhao, Liang, Mahony, Donna, Cavallaro, Antonino S, Zhang, Bing, Zhang, Jun, Deringer, James R, Zhao, Chun-Xia, Brown, Wendy C, Yu, Chengzhong, Mitter, Neena, Middelberg, Anton P J

“…Anaplasma marginale is the most prevalent tick-borne livestock pathogen and poses a significant threat to cattle industry. In contrast to currently available…”
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Stable Ultrathin-Shell Double Emulsions for Controlled Release by Zhao, Chun-Xia, Chen, Dong, Hui, Yue, Weitz, David A., Middelberg, Anton P. J.

“…Double emulsions are normally considered as metastable systems and this limit in stability restricts their applications. To enhance their stability, the outer…”
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Microfluidic Mass-Transfer Control for the Simple Formation of Complex Multiple Emulsions by Zhao, Chun-Xia, Middelberg, Anton P.J

“…Transforming emulsions: A straightforward method for turning a single emulsion into multiple emulsions in a common T‐junction microfluidic device has been…”
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Quantitative analysis of virus-like particle size and distribution by field-flow fractionation by Chuan, Yap P, Fan, Yuan Y, Lua, Linda, Middelberg, Anton P.J

“…Asymmetric flow field-flow fractionation (AFFFF) coupled with multiple-angle light scattering (MALS) is a powerful technique showing potential for the analysis…”
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Co-administration of non-carrier nanoparticles boosts antigen immune response without requiring protein conjugation by Wibowo, Nani, Chuan, Yap P, Seth, Arjun, Cordoba, Yoann, Lua, Linda H.L, Middelberg, Anton P.J

“…Highlights • Silica nanoparticles were used to adjuvant sub-unit protein antigen. • Nanoparticles boosted antigen immune response without protein conjugation…”
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Sustained Release of Fipronil Insecticide in Vitro and in Vivo from Biocompatible Silica Nanocapsules by Wibowo, David, Zhao, Chun-Xia, Peters, Brenton C, Middelberg, Anton P. J

“…A pesticide delivery system made of biocompatible components and having sustained release properties is highly desirable for agricultural applications. In this…”
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Modeling the competition between aggregation and self-assembly during virus-like particle processing by Ding, Yong, Chuan, Yap Pang, He, Lizhong, Middelberg, Anton P.J

“…Understanding and controlling aggregation is an essential aspect in the development of pharmaceutical proteins to improve product yield, potency and quality…”
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Quantitative characterization of virus-like particles by asymmetrical flow field flow fractionation, electrospray differential mobility analysis, and transmission electron microscopy by Pease, Leonard F. III, Lipin, Daniel I, Tsai, De-Hao, Zachariah, Michael R, Lua, Linda H.L, Tarlov, Michael J, Middelberg, Anton P.J

“…Here we characterize virus-like particles (VLPs) by three very distinct, orthogonal, and quantitative techniques: electrospray differential mobility analysis…”
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Self-adjuvanting modular virus-like particles for mucosal vaccination against group A streptococcus (GAS) by Rivera-Hernandez, Tania, Hartas, Jon, Wu, Yang, Chuan, Yap P, Lua, Linda H.L, Good, Michael, Batzloff, Michael R, Middelberg, Anton P.J

“…Graphical abstract Highlights ► Low-cost, effective modular VLP vaccine candidates displaying GAS peptide antigen. ► Unadjuvanted VLP intranasal delivery gave…”
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Protective efficacy of a bacterially produced modular capsomere presenting M2e from influenza: Extending the potential of broadly cross-protecting epitopes by Wibowo, Nani, Hughes, Fiona K, Fairmaid, Emily J, Lua, Linda H.L, Brown, Lorena E, Middelberg, Anton P.J

“…Highlights • Investigation of a modular capsomere vaccine presenting multiple M2e elements. • Protective efficacy demonstrated. • Rapid matching of broadly…”
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Nanoparticle elasticity regulates phagocytosis and cancer cell uptake by Hui, Yue, Yi, Xin, Wibowo, David, Yang, Guangze, Middelberg, Anton P J, Gao, Huajian, Zhao, Chun-Xia

“…The ability of cells to sense external mechanical cues is essential for their adaptation to the surrounding microenvironment. However, how nanoparticle…”
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Synthetic biology for bioengineering virus‐like particle vaccines by Charlton Hume, Hayley K., Vidigal, João, Carrondo, Manuel J. T., Middelberg, Anton P. J., Roldão, António, Lua, Linda H. L.

“…Vaccination is the most effective method of disease prevention and control. Many viruses and bacteria that once caused catastrophic pandemics (e.g., smallpox,…”
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