Search Results - "Middel, Volker"
-
1
Mandipropamid as a chemical inducer of proximity for in vivo applications
Published in Nature chemical biology (01-01-2022)“…Direct control of protein interactions by chemically induced protein proximity holds great potential for both cell and synthetic biology as well as therapeutic…”
Get full text
Journal Article -
2
Dysferlin-mediated phosphatidylserine sorting engages macrophages in sarcolemma repair
Published in Nature communications (19-09-2016)“…Failure to repair the sarcolemma leads to muscle cell death, depletion of stem cells and myopathy. Hence, membrane lesions are instantly sealed by a repair…”
Get full text
Journal Article -
3
Light-controllable dithienylethene-modified cyclic peptides: photoswitching the in vivo toxicity in zebrafish embryos
Published in Beilstein journal of organic chemistry (07-01-2020)“…This study evaluates the embryotoxicity of dithienylethene-modified peptides upon photoswitching, using 19 analogues based on the β-hairpin scaffold of the…”
Get full text
Journal Article -
4
Distinct amino acid motifs carrying multiple positive charges regulate membrane targeting of dysferlin and MG53
Published in PloS one (09-08-2018)“…Dysferlin (Dysf) and mitsugumin53 (MG53) are two key proteins involved in membrane repair of muscle cells which are efficiently recruited to the sarcolemma…”
Get full text
Journal Article -
5
Caveolae disassemble upon membrane lesioning and foster cell survival
Published in iScience (16-02-2024)“…Repair of lesions in the plasma membrane is key to sustaining cellular homeostasis. Cells maintain cytoplasmic as well as membrane-bound stores of repair…”
Get full text
Journal Article -
6
Inhibition of Pseudomonas aeruginosa biofilm formation and expression of virulence genes by selective epimerization in the peptide Esculentin‐1a(1‐21)NH2
Published in The FEBS journal (01-10-2019)“…Pseudomonas aeruginosa is a pathogenic bacterium known to cause serious human infections, especially in immune‐compromised patients. This is due to its unique…”
Get full text
Journal Article -
7
Single Molecule Imaging Reveals Dysferlin-Mediated Recruitment of Phosphatidylserine in Cell Membrane Repair
Published in Biophysical journal (03-02-2017)Get full text
Journal Article -
8
Supreme activity of gramicidin S against resistant, persistent and biofilm cells of staphylococci and enterococci
Published in Scientific reports (29-11-2019)“…Three promising antibacterial peptides were studied with regard to their ability to inhibit the growth and kill the cells of clinical strains of Staphylococcus…”
Get full text
Journal Article -
9
Super-Resolution Imaging of Plasma Membrane Lesions Inflicted by 405-nm Laser Light
Published in Biophysical journal (16-02-2016)Get full text
Journal Article -
10
Correlative in vivo Fluorescence Imaging and 19F-MRI of Zebrafish Embryos
Published in Biophysical journal (07-02-2020)Get full text
Journal Article -
11
Inhibition of Pseudomonas aeruginosa biofilm formation and expression of virulence genes by selective epimerization in the peptide Esculentin-1a(1-21)NH 2
Published in The FEBS journal (01-10-2019)“…Pseudomonas aeruginosa is a pathogenic bacterium known to cause serious human infections, especially in immune-compromised patients. This is due to its unique…”
Get full text
Journal Article -
12
Zebrafish biosensor for toxicant induced muscle hyperactivity
Published in Scientific reports (31-03-2016)“…Robust and sensitive detection systems are a crucial asset for risk management of chemicals, which are produced in increasing number and diversity. To…”
Get full text
Journal Article -
13
Microtome-integrated microscope system for high sensitivity tracking of in-resin fluorescence in blocks and ultrathin sections for correlative microscopy
Published in Scientific reports (19-10-2017)“…Many areas of biological research demand the combined use of different imaging modalities to cover a wide range of magnifications and measurements or to place…”
Get full text
Journal Article