Search Results - "Micol, Jean Baptiste"

Therapy-related myelodysplastic syndromes in the genomics era by Renneville, Aline, Bernard, Elsa, Micol, Jean-Baptiste

“…Therapy-related myelodysplastic syndromes (t-MDS) represent a heterogeneous group of malignancies that arise as a late complication of prior exposure to…”
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Bone marrow metastases mimicking acute leukaemia by Chraïbi, Samy, Vergé, Véronique, Micol, Jean‐Baptiste

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The Role of Additional Sex Combs-Like Proteins in Cancer by Micol, Jean-Baptiste, Abdel-Wahab, Omar

“…Additional sex combs-like (ASXL) proteins are mammalian homologs of Addition of sex combs (Asx), a protein that regulates the balance of trithorax and Polycomb…”
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Comprehensive mutational profiling of core binding factor acute myeloid leukemia by Duployez, Nicolas, Marceau-Renaut, Alice, Boissel, Nicolas, Petit, Arnaud, Bucci, Maxime, Geffroy, Sandrine, Lapillonne, Hélène, Renneville, Aline, Ragu, Christine, Figeac, Martin, Celli-Lebras, Karine, Lacombe, Catherine, Micol, Jean-Baptiste, Abdel-Wahab, Omar, Cornillet, Pascale, Ifrah, Norbert, Dombret, Hervé, Leverger, Guy, Jourdan, Eric, Preudhomme, Claude

“…Acute myeloid leukemia (AML) with t(8;21) or inv(16) have been recognized as unique entities within AML and are usually reported together as core binding…”
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SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition by Kim, Eunhee, Ilagan, Janine O., Liang, Yang, Daubner, Gerrit M., Lee, Stanley C.-W., Ramakrishnan, Aravind, Li, Yue, Chung, Young Rock, Micol, Jean-Baptiste, Murphy, Michele E., Cho, Hana, Kim, Min-Kyung, Zebari, Ahmad S., Aumann, Shlomzion, Park, Christopher Y., Buonamici, Silvia, Smith, Peter G., Deeg, H. Joachim, Lobry, Camille, Aifantis, Iannis, Modis, Yorgo, Allain, Frederic H.-T., Halene, Stephanie, Bradley, Robert K., Abdel-Wahab, Omar

“…Mutations affecting spliceosomal proteins are the most common mutations in patients with myelodysplastic syndromes (MDS), but their role in MDS pathogenesis…”
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Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis by Yoshimi, Akihide, Lin, Kuan-Ting, Wiseman, Daniel H., Rahman, Mohammad Alinoor, Pastore, Alessandro, Wang, Bo, Lee, Stanley Chun-Wei, Micol, Jean-Baptiste, Zhang, Xiao Jing, de Botton, Stephane, Penard-Lacronique, Virginie, Stein, Eytan M., Cho, Hana, Miles, Rachel E., Inoue, Daichi, Albrecht, Todd R., Somervaille, Tim C. P., Batta, Kiran, Amaral, Fabio, Simeoni, Fabrizio, Wilks, Deepti P., Cargo, Catherine, Intlekofer, Andrew M., Levine, Ross L., Dvinge, Heidi, Bradley, Robert K., Wagner, Eric J., Krainer, Adrian R., Abdel-Wahab, Omar

“…Transcription and pre-mRNA splicing are key steps in the control of gene expression and mutations in genes regulating each of these processes are common in…”
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Loss of BAP1 function leads to EZH2-dependent transformation by LaFave, Lindsay M, Béguelin, Wendy, Koche, Richard, Teater, Matt, Spitzer, Barbara, Chramiec, Alan, Papalexi, Efthymia, Keller, Matthew D, Hricik, Todd, Konstantinoff, Katerina, Micol, Jean-Baptiste, Durham, Benjamin, Knutson, Sarah K, Campbell, John E, Blum, Gil, Shi, Xinxu, Doud, Emma H, Krivtsov, Andrei V, Chung, Young Rock, Khodos, Inna, de Stanchina, Elisa, Ouerfelli, Ouathek, Adusumilli, Prasad S, Thomas, Paul M, Kelleher, Neil L, Luo, Minkui, Keilhack, Heike, Abdel-Wahab, Omar, Melnick, Ari, Armstrong, Scott A, Levine, Ross L

“…BAP1 regulation of EZH2 provides therapeutic opportunities in cancer. The tumor suppressors BAP1 and ASXL1 interact to form a polycomb deubiquitinase complex…”
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Clonal interference of signaling mutations worsens prognosis in core-binding factor acute myeloid leukemia by Itzykson, Raphael, Duployez, Nicolas, Fasan, Annette, Decool, Gauthier, Marceau-Renaut, Alice, Meggendorfer, Manja, Jourdan, Eric, Petit, Arnaud, Lapillonne, Hélène, Micol, Jean-Baptiste, Cornillet-Lefebvre, Pascale, Ifrah, Norbert, Leverger, Guy, Dombret, Hervé, Boissel, Nicolas, Haferlach, Torsten, Preudhomme, Claude

“…Mutations in receptor tyrosine kinase/RAS signaling pathway genes are frequent in core-binding factor (CBF) acute myeloid leukemias (AMLs), but their…”
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Acute Abdominal Complications in Deeply Neutropenic Onco-Hematology Patients: A Retrospective Series of 105 Cases by Siebert, Matthieu, Lucas, Nolwenn, Gelli, Maximiliano, sourrouille, Isabelle, Benhaïm, Léonor, Faron, Matthieu, Micol, Jean-Baptiste, Ducreux, Michel, Stoclin, Annabelle, Honoré, Charles

“…Background Acute abdominal complications (AAC) in patients with deep neutropenia (DN) is challenging to manage because of the expected influence of AAC on…”
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ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia by Micol, Jean-Baptiste, Pastore, Alessandro, Inoue, Daichi, Duployez, Nicolas, Kim, Eunhee, Lee, Stanley Chun-Wei, Durham, Benjamin H., Chung, Young Rock, Cho, Hana, Zhang, Xiao Jing, Yoshimi, Akihide, Krivtsov, Andrei, Koche, Richard, Solary, Eric, Sinha, Amit, Preudhomme, Claude, Abdel-Wahab, Omar

“…Additional sex combs-like (ASXL) proteins are mammalian homologues of additional sex combs (Asx), a regulator of trithorax and polycomb function in Drosophila…”
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Germline ATG2B/GSKIP-containing 14q32 duplication predisposes to early clonal hematopoiesis leading to myeloid neoplasms by Pegliasco, Jean, Hirsch, Pierre, Marzac, Christophe, Isnard, Françoise, Meniane, Jean-Côme, Deswarte, Caroline, Pellet, Philippe, Lemaitre, Céline, Leroy, Gwendoline, Rabadan Moraes, Graciela, Guermouche, Hélène, Schmaltz-Panneau, Barbara, Pasquier, Florence, Colas, Chrystelle, Benusiglio, Patrick R., Bera, Odile, Bourhis, Jean-Henri, Brissot, Eolia, Caron, Olivier, Chraibi, Samy, Cony-Makhoul, Pascale, Delaunay-Darivon, Christine, Lapusan, Simona, de Fontbrune, Flore Sicre, Fuseau, Pascal, Najman, Albert, Vainchenker, William, Delhommeau, François, Micol, Jean-Baptiste, Plo, Isabelle, Bellanné-Chantelot, Christine

“…The germline predisposition associated with the autosomal dominant inheritance of the 14q32 duplication implicating ATG2B/GSKIP genes is characterized by a…”
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Serum 2-Hydroxyglutarate Production in IDH1- and IDH2-Mutated De Novo Acute Myeloid Leukemia: A Study by the Acute Leukemia French Association Group by JANIN, Maxime, MYLONAS, Elena, CAILLOT, Denis, PREUDHOMME, Claude, DOMBRET, Hervé, BERTHON, Céline, BAROUKI, Robert, RABIER, Daniel, AUGER, Nathalie, GRISCELLI, Frank, CHACHATY, Elisabeth, LECLERCQ, Edwige, SAADA, Véronique, COURTIER, Marie-Hélène, BENNACEUR-GRISCELLI, Annelise, SOLARY, Eric, BERNARD, Olivier Adrien, PENARD-LACRONIQUE, Virginie, OTTOLENGHI, Chris, DE BOTTON, Stéphane, MICOL, Jean-Baptiste, RENNEVILLE, Aline, QUIVORON, Cyril, KOSCIELNY, Serge, SCOURZIC, Laurianne, FORGET, Sébastien, PAUTAS, Cécile

“…Mutated isocitrate dehydrogenases (IDHs) 1 and 2 produce high levels of 2-hydroxyglutarate (2-HG). We investigated whether, in acute myeloid leukemia (AML),…”
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Myeloid malignancies with translocation t(4;12)(q11‐13;p13): molecular landscape, clonal hierarchy and clinical outcomes by Parinet, Vincent, Chapiro, Elise, Bidet, Audrey, Gaillard, Baptiste, Maarek, Odile, Simon, Laurence, Lefebvre, Christine, Defasque, Sabine, Mozziconacci, Marie‐Joelle, Quinquenel, Anne, Decamp, Matthieu, Lifermann, François, Ali‐Ammar, Nadia, Maillon, Agathe, Baron, Marine, Martin, Mélanie, Struski, Stéphanie, Penther, Dominique, Micol, Jean‐Baptiste, Auger, Nathalie, Bilhou‐Nabera, Chrystèle, Martignoles, Jean‐Alain, Tondeur, Sylvie, Nguyen‐Khac, Florence, Hirsch, Pierre, Roos‐Weil, Damien

“…Translocation t(4;12)(q11‐13;p13) is a recurrent but very rare chromosomal aberration in acute myeloid leukaemia (AML) resulting in the non‐constant expression…”
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Mutational profiling of isolated myeloid sarcomas and utility of serum 2HG as biomarker of IDH1/2 mutations by Willekens, Christophe, Renneville, Aline, Broutin, Sophie, Saada, Véronique, Micol, Jean-Baptiste, Delahousse, Julia, Poinsignon, Vianney, Bories, Claire, Berthon, Céline, Itzykson, Raphael, Boissel, Nicolas, Quivoron, Cyril, Terroir-Cassou-Mounat, Marie, Bosq, Jacques, Preudhomme, Claude, Paci, Angelo, Penard-Lacronique, Virginie, De Botton, Stéphane

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Collaborating constitutive and somatic genetic events in myeloid malignancies: ASXL1 mutations in patients with germline GATA2 mutations by Micol, Jean-Baptiste, Abdel-Wahab, Omar

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Disappearance of slan-positive non-classical monocytes for diagnosis of chronic myelomonocytic leukemia with an associated inflammatory state by Tarfi, Sihem, Badaoui, Bouchra, Freynet, Nicolas, Morabito, Margot, Lafosse, Jeffie, Toma, Andréa, Etienne, Gabriel, Micol, Jean-Baptiste, Sloma, Ivan, Fenaux, Pierre, Solary, Eric, Selimoglu-Buet, Dorothée, Wagner-Ballon, Orianne

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Impact and consequences of intensive chemotherapy on intestinal barrier and microbiota in acute myeloid leukemia: the role of mucosal strengthening by Hueso, Thomas, Ekpe, Kenneth, Mayeur, Camille, Gatse, Anna, Joncquel-Chevallier Curt, Marie, Gricourt, Guillaume, Rodriguez, Christophe, Burdet, Charles, Ulmann, Guillaume, Neut, Christel, Amini, Salah-Eddine, Lepage, Patricia, Raynard, Bruno, Willekens, Christophe, Micol, Jean-Baptiste, De Botton, Stéphane, Yakoub-Agha, Ibrahim, Gottrand, Frédéric, Desseyn, Jean-Luc, Thomas, Muriel, Woerther, Paul-Louis, Seguy, David

“…Induction chemotherapy (7 + 3 regimen) remains the gold standard for patients with acute myeloid leukemia (AML) but is responsible for gut damage leading to…”
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JAK2 and MPL protein levels determine TPO-induced megakaryocyte proliferation vs differentiation by Besancenot, Rodolphe, Roos-Weil, Damien, Tonetti, Carole, Abdelouahab, Hadjer, Lacout, Catherine, Pasquier, Florence, Willekens, Christophe, Rameau, Philippe, Lecluse, Yann, Micol, Jean-Baptiste, Constantinescu, Stefan N., Vainchenker, William, Solary, Eric, Giraudier, Stéphane

“…Megakaryopoiesis is a 2-step differentiation process, regulated by thrombopoietin (TPO), on binding to its cognate receptor myeloproliferative leukemia (MPL)…”
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An atypical promyelocytic sarcoma and pleural effusion in a patient with Gorham's disease: Efficiency of ATRA/ATO‐based treatment by Loyaux, Romain, Lecolant, Solène, Cysique Foilan, Leila, Pradon, Caroline, Cotteret, Sophie, Micol, Jean‐Baptiste, Stoclin, Annabelle, Saada, Véronique, Marzac, Christophe, Arbab, Ahmadreza

“…Key Clinical Message This is the first case of a promyelocytic sarcoma diagnosed on pleural effusion and exposed the difficulty of demonstrating a leukemic…”
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Molecular Landscape of Therapy‐related Myeloid Neoplasms in Patients Previously Treated for Gynecologic and Breast Cancers by Khalife‐Hachem, Sabine, Saleh, Khalil, Pasquier, Florence, Willekens, Christophe, Tarabay, Anthony, Antoun, Leony, Grinda, Thomas, Castilla‐Llorente, Cristina, Duchmann, Matthieu, Quivoron, Cyril, Auger, Nathalie, Saada, Veronique, Delaloge, Suzette, Leary, Alexandra, Renneville, Aline, Antony‐Debre, Ileana, Rosselli, Filippo, De Botton, Stéphane, Salviat, Flore, Marzac, Christophe, Micol, Jean‐Baptiste

“…Definition of therapy‐related myeloid neoplasms (TRMN) is only based on clinical history of exposure to leukemogenic therapy. No specific molecular…”
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