Search Results - "Mickelsen, Deanne"

PDE10A Inactivation Prevents Doxorubicin-Induced Cardiotoxicity and Tumor Growth by Chen, Si, Chen, Jiawei, Du, Wenting, Mickelsen, Deanne M., Shi, Hangchuan, Yu, Han, Kumar, Sparsh, Yan, Chen

“…Cyclic nucleotides play critical roles in cardiovascular biology and disease. PDE10A (phosphodiesterase 10A) is able to hydrolyze both cAMP and cGMP. PDE10A…”
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Sacubitril/Valsartan Decreases Cardiac Fibrosis in Left Ventricle Pressure Overload by Restoring PKG Signaling in Cardiac Fibroblasts by Burke, Ryan M, Lighthouse, Janet K, Mickelsen, Deanne M, Small, Eric M

“…Background Heart failure (HF) is invariably accompanied by development of cardiac fibrosis, a form of scarring that increases muscular tissue rigidity and…”
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A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction by Chen, Si, Zhang, Yishuai, Lighthouse, Janet K., Mickelsen, Deanne M., Wu, Jiangbin, Yao, Peng, Small, Eric M., Yan, Chen

“…BACKGROUND:Heart failure is a leading cause of death worldwide. Cyclic nucleotide phosphodiesterases (PDEs), through degradation of cyclic nucleotides, play…”
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p53 Regulates the Extent of Fibroblast Proliferation and Fibrosis in Left Ventricle Pressure Overload by Liu, Xiaoyi, Burke, Ryan M., Lighthouse, Janet K., Baker, Cameron D., Dirkx, Ronald A., Kang, Brian, Chakraborty, Yashoswini, Mickelsen, Deanne M., Twardowski, Jennifer J., Mello, Stephano S., Ashton, John M., Small, Eric M.

“…Cardiomyopathy is characterized by the pathological accumulation of resident cardiac fibroblasts that deposit ECM (extracellular matrix) and generate a…”
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SIRT6 Mitigates Heart Failure With Preserved Ejection Fraction in Diabetes by Wu, Xiaoqian, Liu, Huan, Brooks, Alan, Xu, Suowen, Luo, Jinque, Steiner, Rebbeca, Mickelsen, Deanne M., Moravec, Christine S., Alexis, Jeffrey D., Small, Eric M., Jin, Zheng Gen

“…Heart failure with preserved ejection fraction (HFpEF) is a growing health problem without effective therapies. Epidemiological studies indicate that diabetes…”
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New approaches in small animal echocardiography: imaging the sounds of silence by Ram, Rashmi, Mickelsen, Deanne M, Theodoropoulos, Catherine, Blaxall, Burns C

“…Systolic and diastolic dysfunction of the left ventricle (LV) is a hallmark of most cardiac diseases. In vivo assessment of heart function in animal models,…”
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PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction by Knight, Walter E., Chen, Si, Zhang, Yishuai, Oikawa, Masayoshi, Wu, Meiping, Zhou, Qian, Miller, Clint L., Cai, Yujun, Mickelsen, Deanne M., Moravec, Christine, Small, Eric M., Abe, Junichi, Yan, Chen

“…Cyclic nucleotide phosphodiesterase 1C (PDE1C) represents a major phosphodiesterase activity in human myocardium, but its function in the heart remains…”
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Simultaneous Adrenal and Cardiac G-Protein–Coupled Receptor-G βγ Inhibition Halts Heart Failure Progression by Kamal, Fadia A., PharmD, PhD, Mickelsen, Deanne M., BS, Wegman, Katherine M, Travers, Joshua G., BS, Moalem, Jacob, MD, Hammes, Stephen R., MD, PhD, Smrcka, Alan V., PhD, Blaxall, Burns C., PhD

“…Objectives The authors propose simultaneous inhibition of Gβγ signaling in the heart and the adrenal gland as a novel therapeutic approach for heart failure…”
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Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors Is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy by Trembley, Michael A, Quijada, Pearl, Agullo-Pascual, Esperanza, Tylock, Kevin M, Colpan, Mert, Dirkx, Ronald A, Myers, Jason R, Mickelsen, Deanne M, de Mesy Bentley, Karen, Rothenberg, Eli, Moravec, Christine S, Alexis, Jeffrey D, Gregorio, Carol C, Dirksen, Robert T, Delmar, Mario, Small, Eric M

“…BACKGROUND:Hypertrophic cardiomyocyte growth and dysfunction accompany various forms of heart disease. The mechanisms responsible for transcriptional changes…”
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Pre-existing fibroblasts of epicardial origin are the primary source of pathological fibrosis in cardiac ischemia and aging by Quijada, Pearl, Misra, Adwiteeya, Velasquez, Lissette S., Burke, Ryan M., Lighthouse, Janet K., Mickelsen, Deanne M., Dirkx, Ronald A., Small, Eric M.

“…Serum response factor (SRF) and the SRF co-activators myocardin-related transcription factors (MRTFs) are essential for epicardium-derived progenitor cell…”
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Model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice by Korshunov, Vyacheslav A., Wang, Hexuan, Ahmed, Rifat, Mickelsen, Deanne M., Zhou, Qian, Yan, Chen, Doyley, Marvin M.

“…Increased arterial thickness measured with ultrasound correlates with future cardiovascular events, but conventional ultrasound imaging techniques cannot…”
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Platelet factor 4 mediates vascular smooth muscle cell injury responses by Shi, Guanfang, Field, David J., Long, Xiaochun, Mickelsen, Deanne, Ko, Kyung-ae, Ture, Sara, Korshunov, Vyacheslav A., Miano, Joseph M., Morrell, Craig N.

“…Activated platelets release many inflammatory molecules with important roles in accelerating vascular inflammation. Much is known about platelet and…”
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The Protective Role of Natriuretic Peptide Receptor 2 against High Salt Injury in the Renal Papilla by Dugbartey, George J., Quinn, Breandan, Luo, Lingfeng, Mickelsen, Deanne M., Ture, Sara K., Morrell, Craig N., Czyzyk, Jan, Doyley, Marvin M., Yan, Chen, Berk, Bradford C., Korshunov, Vyacheslav A.

“…Mutations in natriuretic peptide receptor 2 (Npr2) gene cause a rare form of short-limbed dwarfism, but its physiological effects have not been well studied…”
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Innate Immune Cells Are Regulated by Axl in Hypertensive Kidney by Batchu, Sri N., Dugbartey, George J., Wadosky, Kristine M., Mickelsen, Deanne M., Ko, Kyung A., Wood, Ronald W., Zhao, Yuqi, Yang, Xia, Fowell, Deborah J., Korshunov, Vyacheslav A.

“…The balance between adaptive and innate immunity in kidney damage in salt-dependent hypertension is unclear. We investigated early renal dysfunction and the…”
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Natriuretic Peptide Receptor 2 Locus Contributes to Carotid Remodeling by Korshunov, Vyacheslav A, Smolock, Elaine M, Wines-Samuelson, Mary E, Faiyaz, Abrar, Mickelsen, Deanne M, Quinn, Breandan, Pan, Calvin, Dugbartey, George J, Yan, Chen, Doyley, Marvin M, Lusis, Aldons J, Berk, Bradford C

“…Background Carotid artery intima/media thickness (IMT) is a hallmark trait associated with future cardiovascular events. The goal of this study was to map new…”
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Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor by Woo, Chang-Hoon, Le, Nhat-Tu, Shishido, Tetsuro, Chang, Eugene, Lee, Hakjoo, Heo, Kyung-Sun, Mickelsen, Deanne M, Lu, Yan, McClain, Carolyn, Spangenberg, Thomas, Yan, Chen, Molina, Carlos A, Yang, Jay, Patterson, Cam, Abe, Jun-ichi

“…Growing evidence indicates a critical role of ubiquitin-proteosome system in apoptosis regulation. A cardioprotective effect of ubiquitin (Ub) ligase of the C…”
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Cardiac overexpression of Mammalian enabled (Mena) exacerbates heart failure in mice by Belmonte, Stephen L, Ram, Rashmi, Mickelsen, Deanne M, Gertler, Frank B, Blaxall, Burns C

“…Mammalian enabled (Mena) is a key regulator of cytoskeletal actin dynamics, which has been implicated in heart failure (HF). We have previously demonstrated…”
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Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor by Woo, Chang-Hoon, Le, Nhat-Tu, Shishido, Tetsuro, Chang, Eugene, Lee, Hakjoo, Heo, Kyung-Sun, Mickelsen, Deanne M, Lu, Yan, McClain, Carolyn, Spangenberg, Thomas, Yan, Chen, Molina, Carlos A, Yang, Jay, Patterson, Cam, Abe, Jun-ichi

“…Growing evidence indicates a critical role of ubiquitin-proteosome system in apoptosis regulation. A cardioprotective effect of ubiquitin (Ub) ligase of the C…”
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Decomplexification in critical illness and injury: Relationship between heart rate variability, severity of illness, and outcome by Goldstein, Brahm, Fiser, Debra H, Kelly, Mary M, Mickelsen, Deanne, Ruttimann, Urs, Pollack, Murray M

“…OBJECTIVESTo determine if decomplexification of heart rate dynamics occurs in critically ill and injured pediatric patients. We hypothesized that heart rate…”
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Abstract MP265: The Role Of Phosphodiesterase 10a In Tumor Growth And Doxorubicin-induced Cardiotoxicity by Chen, Si, Chen, Jiawei, Shi, Hangchuan, Mickelsen, Deanne, Yan, Chen

“…Cyclic nucleotide phosphodiesterases (PDEs), through the degradation of cyclic nucleotides, play critical roles in cardiovascular biology and disease. PDE10A…”
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