Search Results - "Michiels, Paul J."

Identification of lignans and related compounds in Anthriscus sylvestris by LC–ESI-MS/MS and LC-SPE–NMR by Hendrawati, Oktavia, Woerdenbag, Herman J., Michiels, Paul J.A., Aantjes, Herald G., van Dam, Annie, Kayser, Oliver

“…We identified nine lignans and five related structures in roots of Anthriscus sylvestris (L.) Hoffm. (Apiaceae). A hypothetical biosynthetic pathway of…”
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SALMON: Solvent Accessibility, Ligand binding, and Mapping of ligand Orientation by NMR Spectroscopy by Ludwig, Christian, Michiels, Paul J. A, Wu, Xiaoqiu, Kavanagh, Kathryn L, Pilka, Ewa, Jansson, Anna, Oppermann, Udo, Günther, Ulrich L

“…Quinone oxidoreductase 2 (NQO2) binds the prodrug tretazicar (also known as CB1954, 5-(aziridin-1-yl)-2,4-dinitrobenzamide), which exhibits a profound…”
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Simultaneous analysis of plasma and CSF by NMR and hierarchical models fusion by Smolinska, Agnieszka, Posma, Joram M., Blanchet, Lionel, Ampt, Kirsten A. M., Attali, Amos, Tuinstra, Tinka, Luider, Theo, Doskocz, Marek, Michiels, Paul J., Girard, Frederic C., Buydens, Lutgarde M. C., Wijmenga, Sybren S.

“…Because cerebrospinal fluid (CSF) is the biofluid which interacts most closely with the central nervous system, it holds promise as a reporter of neurological…”
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Magnetic susceptibility to measure total protein concentration from NMR metabolite spectra: Demonstration on blood plasma by Jupin, Marc, Michiels, Paul J., Girard, Frederic C., Wijmenga, Sybren S.

“…Purpose Accurate metabolite and protein quantification in blood plasma and other body fluids from one single NMR measurement, allowing for improved…”
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NMR identification of endogenous metabolites interacting with fatted and non-fatted human serum albumin in blood plasma: Fatty acids influence the HSA–metabolite interaction by Jupin, Marc, Michiels, Paul J., Girard, Frederic C., Spraul, Manfred, Wijmenga, Sybren S.

“…[Display omitted] ▸ Interaction with HSA of 20 common blood plasma metabolites is investigated by NMR. ▸ Most of these metabolites bind to HSA, but are…”
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Surface Plasmon Resonance Evaluation of Various Aminoglycoside-RNA Hairpin Interactions Reveals Low Degree of Selectivity by Verhelst, Steven H.L, Michiels, Paul J.A, van der Marel, Gijsbert A, van Boeckel, Constant A.A, van Boom, Jacques H

“…Aminoglycoside antibiotics, which are able to selectively bind to RNA, are considered to be an important lead in RNA-targeting drug discovery. In this study,…”
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Targeting RNA: new opportunities to address drugless targets by Zaman, Guido J.R, Michiels, Paul J.A, van Boeckel, Constant A.A

“…Historically, pharmaceutical industries have focussed on the discovery of compounds that target the protein products of genes. The intermediary product between…”
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Ligand-based NMR spectra demonstrate an additional phytoestrogen binding site for 17β-hydroxysteroid dehydrogenase type 1 by Michiels, Paul J.A., Ludwig, Christian, Stephan, Michel, Fischer, Christina, Möller, Gabriele, Messinger, Josef, van Dongen, Maria, Thole, Hubert, Adamski, Jerzy, Günther, Ulrich L.

“…The enzyme 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) has become an important drug target for breast cancer because it catalyzes the interconversion of…”
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Ligand-based NMR spectra demonstrate an additional phytoestrogen binding site for 17beta-hydroxysteroid dehydrogenase type 1 by Michiels, Paul J A, Ludwig, Christian, Stephan, Michel, Fischer, Christina, Möller, Gabriele, Messinger, Josef, van Dongen, Maria, Thole, Hubert, Adamski, Jerzy, Günther, Ulrich L

“…The enzyme 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) has become an important drug target for breast cancer because it catalyzes the…”
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New developments in structure determination of pseudoknots by Hilbers, Cornelis W., Michiels, Paul J. A., Heus, Hans A.

“…Recently, several high‐resolution structures of RNA pseudoknots have become available. Here we review the progress in this area. The majority of the structures…”
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