Search Results - "Michelson, Stuart"

Design and Synthesis of 8-Hydroxy-[1,6]Naphthyridines as Novel Inhibitors of HIV-1 Integrase in Vitro and in Infected Cells by Zhuang, Linghang, Wai, John S, Embrey, Mark W, Fisher, Thorsten E, Egbertson, Melissa S, Payne, Linda S, Guare, James P, Vacca, Joseph P, Hazuda, Daria J, Felock, Peter J, Wolfe, Abigail L, Stillmock, Kara A, Witmer, Marc V, Moyer, Gregory, Schleif, William A, Gabryelski, Lori J, Leonard, Yvonne M, Lynch, Joseph J, Michelson, Stuart R, Young, Steven D

“…Naphthyridine 7 inhibits the strand transfer of the integration process catalyzed by integrase with an IC50 of 10 nM and inhibits 95% of the spread of HIV-1…”
Get full text

The Sarbanes-Oxley Act of 2002: what impact has it had on small business firms? by Michelson, Stuart, Stryker, Jud, Thorne, Betty

“…Purpose - The purpose of this paper is to explore the impact of the Sarbanes-Oxley (SOX) Act of 2002 on small corporations when compared to large firms and to…”
Get full text

Orally Efficacious NR2B-Selective NMDA Receptor Antagonists by Claiborne, Christopher F, McCauley, John A, Libby, Brian E, Curtis, Neil R, Diggle, Helen J, Kulagowski, Janusz J, Michelson, Stuart R, Anderson, Kenneth D, Claremon, David A, Freidinger, Roger M, Bednar, Rodney A, Mosser, Scott D, Gaul, Stanley L, Connolly, Thomas M, Condra, Cindra L, Bednar, Bohumil, Stump, Gary L, Lynch, Joseph J, Macaulay, Alison, Wafford, Keith A, Koblan, Kenneth S, Liverton, Nigel J

“…A novel series of benzamidines was synthesized and shown to exhibit NR2B-subtype selective NMDA antagonist activity. Compound 31 is orally active in a…”
Get full text

The Earnings Forecast Accuracy of Financial Analysts Who are CFA Charterholders by Fortin, Rich, Michelson, Stuart E

“…This article examines the earnings forecast accuracy of financial analysts who have earned the right to use the CFA designation. Given the extensive rigor of…”
Get full text

AUDITOR CONCENTRATION AND MARKET SHARES IN THE US: 1988–1999 A DESCRIPTIVE NOTE by WOLK, CAREL M., MICHELSON, STUART E., WOOTTON, CHARLES W.

“…This paper examines from a historical perspective the effects of the Big Eight and Big Six accounting firm mergers on concentration measures and market share…”
Get full text

Risk Budgeting, Parameter Uncertainty,and Risk Realizations by Gilkeson, James H., Michelson, Stuart E.

“…Risk budgeting is a process by which investors make asset allocation decisions subject to a portfolio-to-benchmark tracking error constraint. We use…”
Get full text

Patterns in Analysts' Long-Term Earnings Forecasts by Fortin, Rich, Gilkeson, James H, Michelson, Stuart E

“…This article examines the accuracy of analysts' long-term estimates (made before the beginning of the year being forecast) of annual operating earnings during…”
Get full text

The Tax Impacts of Home Mortgage Refinancing: An Analysis and a Model by Fortin, Rich, Michelson, Stuart

“…This paper provides pertinent information for investors about refinancing their mortgages. It discusses the input variables and how to compute the breakeven…”
Get full text

The relationship between the smoothing of reported income and risk-adjusted returns by Michelson, Stuart E., Jordan-Wagner, James, Wootton, Charles W.

“…This paper uses risk-adjusted returns for the firms in the S&P 500 to test whether the stock market response to accounting performance measures is related to…”
Get full text

Manager Skill and Risk Budgeting by Gilkeson, James H., Michelson, Stuart E.

“…Risk budgeting seeks to maximize expected alpha subject to a total tracking error constraint for the portfolio. Investors follow their strategic asset…”
Get full text

New isomeric classes of topically active ocular hypotensive carbonic anhydrase inhibitors: 5-substituted thieno[2,3-b]thiophene-2-sulfonamides and 5-substituted thieno[3,2-b]thiophene-2-sulfonamides by Prugh, John D, Hartman, George D, Mallorga, Pierre J, McKeever, Brian M, Michelson, Stuart R, Murcko, Mark A, Schwam, Harvey, Smith, Robert L, Sondey, John M

“…A series of 5-substituted thieno[2,3-b]- and thieno[3,2-b)- and thieno[3,2-b)thiophene-2-sulfonamides was prepared and evaluated for topical ocular hypotensive…”
Get full text

The information contents of senior offerings that reduce junior securities by Hull, Robert M, Michelson, Stuart E

“…This study examines 196 pure leverage increases consisting of senior offerings that reduce junior securities. The following contributions not previously…”
Get full text

Identification of MK-944a:  A Second Clinical Candidate from the Hydroxylaminepentanamide Isostere Series of HIV Protease Inhibitors by Dorsey, Bruce D, McDonough, Colleen, McDaniel, Stacey L, Levin, Rhonda B, Newton, Christina L, Hoffman, Jacob M, Darke, Paul L, Zugay-Murphy, Joan A, Emini, Emilio A, Schleif, William A, Olsen, David B, Stahlhut, Mark W, Rutkowski, Carrie A, Kuo, Lawrence C, Lin, Jiunn H, Chen, I-W, Michelson, Stuart R, Holloway, M. Katharine, Huff, Joel R, Vacca, Joseph P

“…Recent results from human clinical trials have established the critical role of HIV protease inhibitors in the treatment of acquired immune-deficiency syndrome…”
Get full text

Designing Usable Voting Systems for Voters With Hidden Barriers: A Pilot Study by Harley, Linda, Kline, Keith, Bell, Carrie, Baranak, Andrew, Michelson, Stuart, Farmer, Sarah, Fain, Brad

“…Little research has been conducted considering how to improve the usability of voting systems for people with hidden barriers, including voters with dyslexia,…”
Get full text

Development of Orally Active Oxytocin Antagonists:  Studies on 1-(1-{4-[1-(2-Methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl}piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and Related Pyridines by Bell, Ian M, Erb, Jill M, Freidinger, Roger M, Gallicchio, Steven N, Guare, James P, Guidotti, Maribeth T, Halpin, Rita A, Hobbs, Doug W, Homnick, Carl F, Kuo, Michelle S, Lis, Edward V, Mathre, David J, Michelson, Stuart R, Pawluczyk, Joseph M, Pettibone, Douglas J, Reiss, Duane R, Vickers, Stanley, Williams, Peter D, Woyden, Carla J

“…The previously reported oxytocin antagonist L-371,257 (2) has been modified at its acetylpiperidine terminus to incorporate various pyridine N-oxide groups…”
Get full text

Topically active carbonic anhydrase inhibitors. 3. Benzofuran- and indole-2-sulfonamides by Graham, Samuel L, Hoffman, Jacob M, Gautheron, Pierre, Michelson, Stuart R, Scholz, Thomas H, Schwam, Harvey, Shepard, Kenneth L, Smith, Anthony M, Smith, Robert L

“…Derivatives of benzofuran- and indole-2-sulfonamide were prepared for evaluation as topically active ocular hypotensive agents. These compounds were found to…”
Get full text

3-Substituted thieno[2,3-b][1,4]thiazine-6-sulfonamides. A novel class of topically active carbonic anhydrase inhibitors by Hunt, Cecilia A, Mallorga, Pierre J, Michelson, Stuart R, Schwam, Harvey, Sondey, John M, Smith, Robert L, Sugrue, Michael F, Shepard, Kenneth L

“…3-Aminoalkyl derivatives of thieno[2,3-b][1,4]thiazine-6-sulfonamide were prepared for evaluation as topically active ocular hypotensive agents. The compounds…”
Get full text

Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors by Hartman, George D, Halczenko, Wasyl, Prugh, John D, Smith, Robert L, Sugrue, Michael F, Mallorga, Pierre, Michelson, Stuart R, Randall, William C, Schwam, Harvey, Sondey, John M

“…Novel 5-[(alkylamino)methyl]thieno[2,3-b]furan-2-sulfonamides were prepared and evaluated in vitro for inhibition of human carbonic anhydrase II (CA II) and ex…”
Get full text

(Acyloxy)alkyl carbamates as novel bioreversible prodrugs for amines: increased permeation through biological membranes by Alexander, Jose, Cargill, Robyn, Michelson, Stuart R, Schwam, Harvey

Get full text

4-Substituted thiophene- and furan-2-sulfonamides as topical carbonic anhydrase inhibitors by Hartman, George D, Halczenko, Wasyl, Smith, Robert L, Sugrue, Michael F, Mallorga, Pierre J, Michelson, Stuart R, Randall, William C, Schwam, Harvey, Sondey, John M

“…A series of 4-substituted thiophene- and furan-2-sulfonamides was prepared and was found to possess nanomolar-level potency for inhibition of human carbonic…”
Get full text