Search Results - "Michelsen, Birgitte"

Determinants of the Impaired Secretion of Glucagon-Like Peptide-1 in Type 2 Diabetic Patients by Toft-Nielsen, Mai-Britt, Damholt, Mette B., Madsbad, Sten, Hilsted, Linda M., Hughes, Thomas E., Michelsen, Birgitte K., Holst, Jens J.

“…To elucidate the causes of the diminished incretin effect in type 2 diabetes mellitus we investigated the secretion of the incretin hormones, glucagon-like…”
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Histone deacetylase inhibitors: a new class of immunosuppressors targeting a novel signal pathway essential for CD154 expression by Skov, Søren, Rieneck, Klaus, Bovin, Lone Frier, Skak, Kresten, Tomra, Søren, Michelsen, Birgitte K., Ødum, Niels

“…Here we report that histone deacetylase inhibitors (HDAC-i) comprise a new class of immunosuppressive agents. HDAC-i inhibited CD4 T-cell proliferation in a…”
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Different diabetogenic potential of autoaggressive CD8+ clones associated with IFN-gamma-inducible protein 10 (CXC chemokine ligand 10) production but not cytokine expression, cytolytic activity, or homing characteristics by Ejrnaes, Mette, Videbaek, Nicoline, Christen, Urs, Cooke, Anne, Michelsen, Birgitte K, von Herrath, Matthias

“…Type 1 diabetes mellitus is an autoimmune disease characterized by T cell-mediated destruction of the insulin-producing beta cells in the islets of Langerhans…”
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Local Activation of Dendritic Cells Leads to Insulitis and Development of Insulin-Dependent Diabetes in Transgenic Mice Expressing CD154 on the Pancreatic β-Cells by HAASE, Claus, SKAK, Kresten, MICHELSEN, Birgitte K, MARKHOLST, Helle

“…Local Activation of Dendritic Cells Leads to Insulitis and Development of Insulin-Dependent Diabetes in Transgenic Mice Expressing CD154 on the Pancreatic…”
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Preservation of β‐cell function during immune‐mediated, B7‐1‐dependent α‐cell destruction by Skak, Kresten, Haase, Claus, Michelsen, Birgitte K.

“…Type 1 diabetes (T1D) is an autoimmune disease in which the pancreatic β‐cells are destroyed in an immune‐mediated process. In one mouse model of T1D, the…”
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Both exogenous and endogenous interleukin‐10 affects the maturation of bone‐marrow‐derived dendritic cells in vitro and strongly influences T‐cell priming in vivo by Haase, Claus, Jørgensen, Trine N., Michelsen, Birgitte K.

“…Summary In order to avoid autoimmunity and excessive tissue destruction, the action of certain immunoinhibitory substances are very important for negative…”
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Detection of GAD65 antibodies in diabetes and other autoimmune diseases using a simple radioligand assay by PETERSEN, J. S, HEJNÆS, K. R, MOODY, A, KARLSEN, A. E, MARSHALL, M. O, HØIER-MADSEN, M, BOEL, E, MICHELSEN, B. K, DYRBERG, T

“…Autoantibodies to glutamic acid decarboxylase (GAD) are frequent at or before the onset of insulin-dependent diabetes mellitus (IDDM). We have developed a…”
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Transcriptional Regulation of the Human Insulin Gene is Dependent on the Homeodomain Protein STF1/IPF1 Acting Through the CT Boxes by Petersen, Helle V., Serup, Palle, Leonard, James, Michelsen, Birgitte K., Madsen, Ole D.

“…Insulin gene transcription is a unique feature of the pancreatic β cells and is increased in response to glucose. The recent cloning of insulin promoter factor…”
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TNF‐α impairs peripheral tolerance towards β‐cells, and local costimulation by B7.1 enhances the effector function of diabetogenic T cells by Skak, Kresten, Guerder, Sylvie, Picarella, Dominic E., Brenden, Nina, Flavell, Richard A., Michelsen, Birgitte K.

“…Maintenance of peripheral tolerance and inactivation of autoreactive T cells is based on a delicate balance between pro‐inflammatory and protective cytokines…”
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An islet-homing NOD CD8+ cytotoxic T cell clone recognizes GAD65 and causes insulitis by VIDEBAEK, Nicoline, HARACH, Silvia, PHILLIPS, Jenny, HUTCHINGS, Patricia, OZEGBE, Patricia, MICHELSEN, Birgitte K, COOKE, Anne

“…T cells play a central role in the development of diabetes both in man and in the non-obese diabetic (NOD) mouse. Both the CD4(+) and CD8(+) subsets of T cells…”
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Autoantibodies in IDDM primarily recognize the 65,000-Mr rather than the 67,000-Mr isoform of glutamic acid decarboxylase by Hagopian, William A, Michelsen, Birgitte, Karlsen, Allan E, Larsen, Fleming, Moody, Alistar, Grubin, Catherine E, Rowe, Rachel, Peterson, Jacob, McEvoy, Robert, Lernmark, Ake

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Low Expression of Insulin in the Thymus of Non-obese Diabetic Mice by Brimnes, Marie K., Jensen, Teis, Jørgensen, Trine N., Michelsen, Birgitte K., Troelsen, Jesper, Werdelin, Ole

“…Insulin is a predominant autoantigen in IDDM in man and the NOD mouse. Failure of negative selection of diabetogenic T cells in thymus may be an important…”
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Recombinant glutamic acid decarboxylase (representing the single isoform expressed in human islets) detects IDDM-associated 64,000-Mr autoantibodies by KARLSEN, A. E, HAGOPIAN, W. A, PETERSEN, J. S, BOEL, E, DYRBERG, T, GRUBIN, C. E, MICHELSEN, B. K, MADSEN, O. D, LERNMARK, A

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Differential expression of glutamic acid decarboxylase in rat and human islets by PETERSEN, J. S, RUSSEL, S, MOODY, A, DYRBERG, T, LERNMARK, Å, MADSEN, O. D, MICHELSEN, B. K, MARSHALL, M. O, KOFOD, H, BUSCHARD, K, CAMBON, N, KARLSEN, A. E, BOEL, E, HAGOPIAN, W. A, HEJNÆS, K. R

“…The GABA synthesizing enzyme GAD is a prominent islet cell autoantigen in type I diabetes. The two forms of GAD (GAD64 and GAD67) are encoded by different…”
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Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes by SEEWALDT, Sonja, THOMAS, Helen E, EJRNAES, Mette, CHRISTEN, Urs, WOLFE, Tom, RODRIGO, Evelyn, COON, Bryan, MICHELSEN, Birgitte, KAY, Thomas W. H, VON HERRATH, Matthias G

“…Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes…”
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Diabetes in the Old Order Amish: characterization and heritability analysis of the Amish Family Diabetes Study by HSUEH, W.-C, MITCHELL, B. D, BURNS, D. K, BELL, C. J, SHULDINER, A. R, ABUROMIA, R, POLLIN, T, SAKUL, H, EHM, M. G, MICHELSEN, B. K, WAGNER, M. J, JEAN, P. L. S, KNOWLER, W. C

“…Diabetes in the Old Order Amish: characterization and heritability analysis of the Amish Family Diabetes Study. W C Hsueh , B D Mitchell , R Aburomia , T…”
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Local Activation of Dendritic Cells Leads to Insulitis and Development of Insulin-Dependent Diabetes in Transgenic Mice Expressing CD154 on the Pancreatic β-Cells by Haase, Claus, Skak, Kresten, Michelsen, Birgitte K, Markholst, Helle

“…The initial events leading to activation of the immune system in type 1 diabetes are still largely unknown. In vivo, dendritic cells (DCs) are thought to be…”
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Local activation of dendritic cells leads to insulitis and development of insulin-dependent diabetes in transgenic mice expressing CD154 on the pancreatic [beta]-cells.(Immunology And Transplantation) by Haase, Claus, Skak, Kresten, Michelsen, Birgitte K, Markholst, Helle

“…The initial events leading to activation of the immune system in type 1 diabetes are still largely unknown. In vivo, dendritic cells (DCs) are thought to be…”
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Growth Hormone and Prolactin Stimulate the Expression of Rat Preadipocyte Factor-1/Δ-Like Protein in Pancreatic Islets: Molecular Cloning and Expression Pattern during Development and Growth of the Endocrine Pancreas by Carlsson, Carina, Tornehave, Ditte, Lindberg, Karen, Galante, Philip, Billestrup, Nils, Michelsen, Birgitte, Larsson, Lars-Inge, Nielsen, Jens H.

“…Abstract GH and PRL have been shown to stimulate proliferation and insulin production in islets of Langerhans. To identify genes regulated by GH/PRL in islets,…”
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Different Diabetogenic Potential of Autoaggressive CD8 super(+) Clones Associated with IFN- gamma -Inducible Protein 10 (CXC Chemokine Ligand 10) Production but Not Cytokine Expression, Cytolytic Activity, or Homing Characteristics by Ejrnaes, Mette, Videbaek, Nicoline, Christen, Urs, Cooke, Anne, Michelsen, Birgitte K, von herrath, Matthias

“…Type 1 diabetes mellitus is an autoimmune disease characterized by T cell- mediated destruction of the insulin-producing beta cells in the islets of…”
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