Search Results - "Michels, Alexander J"

There is no evidence that vitamin D supplementation drives the progression of Alzheimer's disease by Gombart, Adrian F., Michels, Alexander J., Eggersdorfer, Manfred

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Myths, artifacts, and fatal flaws: identifying limitations and opportunities in vitamin C research by Michels, Alexander J, Frei, Balz

“…Research progress to understand the role of vitamin C (ascorbic acid) in human health has been slow in coming. This is predominantly the result of several…”
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Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function by Michels, Alexander J, Hagen, Tory M, Frei, Balz

“…New evidence for the regulation of vitamin C homeostasis has emerged from several studies of human genetic variation. Polymorphisms in the genes encoding…”
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Multivitamin/Multimineral Supplementation Prevents or Reverses Decline in Vitamin Biomarkers and Cellular Energy Metabolism in Healthy Older Men: A Randomized, Double-Blind, Placebo-Controlled Study by Michels, Alexander J, Butler, Judy A, Uesugi, Sandra L, Lee, Ken, Frei, Balz B, Bobe, Gerd, Magnusson, Kathy R, Hagen, Tory M

“…Despite the reported prevalence of micronutrient deficiencies in older adults, it is not yet established whether multivitamin/multimineral (MV/MM) supplements…”
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The Effect of a Multivitamin and Mineral Supplement on Immune Function in Healthy Older Adults: A Double-Blind, Randomized, Controlled Trial by Fantacone, Mary L, Lowry, Malcolm B, Uesugi, Sandra L, Michels, Alexander J, Choi, Jaewoo, Leonard, Scott W, Gombart, Sean K, Gombart, Jeffrey S, Bobe, Gerd, Gombart, Adrian F

“…Older adults are at increased risk for vitamin and mineral deficiencies that contribute to age-related immune system decline. Several lines of evidence suggest…”
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Grape Seed and Tea Extracts and Catechin 3-Gallates Are Potent Inhibitors of α-Amylase and α-Glucosidase Activity by Yilmazer-Musa, Meltem, Griffith, Anneke M, Michels, Alexander J, Schneider, Erik, Frei, Balz

“…This study evaluated the inhibitory effects of plant-based extracts (grape seed, green tea, and white tea) and their constituent flavan-3-ol monomers…”
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Vitamin C by Lykkesfeldt, Jens, Michels, Alexander J., Frei, Balz

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Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response by Shay, Kate Petersen, Michels, Alexander J., Li, Wenge, Kong, Ah-Ng Tony, Hagen, Tory M.

“…Little is known about either the basal or stimulated homeostatic mechanisms regulating nuclear tenure of Nf-e2-related factor 2 (Nrf2), a transcription factor…”
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Daily Consumption of Oregon Hazelnuts Affects α-Tocopherol Status in Healthy Older Adults: A Pre-Post Intervention Study by Michels, Alexander J, Leonard, Scott W, Uesugi, Sandra L, Bobe, Gerd, Frei, Balz, Traber, Maret G

“…Inadequate vitamin E and magnesium intakes are of concern for older adults owing to the associated incidence of age-related diseases. This study was designed…”
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A Randomized Controlled Trial of Long-Term (R)-α-Lipoic Acid Supplementation Promotes Weight Loss in Overweight or Obese Adults without Altering Baseline Elevated Plasma Triglyceride Concentrations by Bobe, Gerd, Michels, Alexander J, Zhang, Wei-Jian, Purnell, Jonathan Q, Woffendin, Clive, Pereira, Cliff, Vita, Joseph A, Thomas, Nicholas O, Traber, Maret G, Frei, Balz, Hagen, Tory M

“…α-Lipoic acid (LA) is a dietary supplement for maintaining energy balance, but well-controlled clinical trials in otherwise healthy, overweight adults using LA…”
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Perspective: Council for Responsible Nutrition Science in Session. Optimizing Health with Nutrition—Opportunities, Gaps, and the Future by Ho, Emily, Drake, Victoria J., Michels, Alexander J., Nkrumah-Elie, Yasmeen M., Brown, LaVerne L., Scott, Jonathan M., Newman, John W., Shukitt-Hale, Barbara, Soumyanath, Amala, Chilton, Floyd H., Lindemann, Stephen R., Shao, Andrew, Mitmesser, Susan Hazels

“…Achieving optimal health is an aspirational goal for the population, yet the definition of health remains unclear. The role of nutrition in health has evolved…”
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Hepatocyte nuclear factor 1 is essential for transcription of sodium-dependent vitamin C transporter protein 1 by Michels, Alexander J, Hagen, Tory M

“…Transport and distribution of vitamin C is primarily regulated by the function of sodium-dependent vitamin C transporters (SVCTs). SVCT1 is expressed in the…”
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A new twist on an old vitamin: human polymorphisms in the gene encoding the sodium-dependent vitamin C transporter 1 by Michels, Alexander J, Hagen, Tory M, Frei, Balz

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( R)-α-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria by Monette, Jeffrey S., Gómez, Luis A., Moreau, Régis F., Dunn, Kevin C., Butler, Judy A., Finlay, Liam A., Michels, Alexander J., Shay, Kate Petersen, Smith, Eric J., Hagen, Tory M.

“…Inflammation results in heightened mitochondrial ceramide levels, which cause electron transport chain dysfunction, elevates reactive oxygen species, and…”
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Age-related decline of sodium-dependent ascorbic acid transport in isolated rat hepatocytes by Michels, Alexander J, Joisher, Neha, Hagen, Tory M

“…This study investigated whether the age-related decline in hepatic ascorbic acid (AA) levels in rats was due to altered AA uptake. AA concentrations were 68%…”
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Cell Culture Conditions Critically Affect Cytotoxicity of Millimolar Ascorbate in Both Cancer and Normal Cells by Michels, Alexander J, Firsick, Evan J, Frei, Balz

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306 - Cell Culture Conditions Critically Affect Cytotoxicity of Millimolar Ascorbate in Both Cancer and Normal Cells by Michels, Alexander J, Firsick, Evan J, Frei, Balz

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Micronutrient status assessment in humans: Current methods of analysis and future trends by Höller, Ulrich, Bakker, Stephan J.L., Düsterloh, Andre, Frei, Balz, Köhrle, Josef, Konz, Tobias, Lietz, Georg, McCann, Adrian, Michels, Alexander J., Molloy, Anne M., Murakami, Hitoshi, Rein, Dietrich, Saris, Wim H.M., Schmidt, Karlheinz, Shimbo, Kazutaka, Schumacher, Soeren, Vermeer, Cees, Kaput, Jim, Weber, Peter, Eggersdorfer, Manfred, Rezzi, Serge

“…Micronutrients are essential to health at every life stage and their deficiencies are associated with increased incidence of various pathophysiological states…”
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Vitamin C1 by Lykkesfeldt, Jens, Michels, Alexander J., Frei, Balz

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Human Genetic Variation Influences Vitamin C Homeostasis by Altering Vitamin Transport and Antioxidant Enzyme Function by MICHELS, Alexander J, HAGEN, Tory M, FREI, Balz

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