Search Results - "Michelozzi, Ilaria M"

High-dimensional functional phenotyping of preclinical human CAR T cells using mass cytometry by Michelozzi, Ilaria M., Sufi, Jahangir, Adejumo, Thomas A., Amrolia, Persis J., Tape, Christopher J., Giustacchini, Alice

“…Here, we present a comprehensive protocol for the generation and functional characterization of chimeric antigen receptor (CAR) T cells and their products by…”
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Driving CAR T Stem Cell Targeting in Acute Myeloid Leukemia: The Roads to Success by Michelozzi, Ilaria M, Kirtsios, Efstratios, Giustacchini, Alice

“…Current treatment outcome for acute myeloid leukemia (AML) patients is unsatisfactory and characterized by high rates of relapse and poor overall survival…”
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Acute myeloid leukaemia niche regulates response to L‐asparaginase by Michelozzi, Ilaria M., Granata, Valentina, De Ponti, Giada, Alberti, Gaia, Tomasoni, Chiara, Antolini, Laura, Gambacorti‐Passerini, Carlo, Gentner, Bernhard, Dazzi, Francesco, Biondi, Andrea, Coliva, Tiziana, Rizzari, Carmelo, Pievani, Alice, Serafini, Marta

“…Summary Eradicating the malignant stem cell is the ultimate challenge in the treatment of leukaemia. Leukaemic stem cells (LSC) hijack the normal haemopoietic…”
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Human aplastic anaemia‐derived mesenchymal stromal cells form functional haematopoietic stem cell niche in vivo by Michelozzi, Ilaria M., Pievani, Alice, Pagni, Fabio, Antolini, Laura, Verna, Marta, Corti, Paola, Rovelli, Attilio, Riminucci, Mara, Dazzi, Francesco, Biondi, Andrea, Serafini, Marta

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Activation priming and cytokine polyfunctionality modulate the enhanced functionality of low-affinity CD19 CAR T cells by Michelozzi, Ilaria M., Gomez-Castaneda, Eduardo, Pohle, Ruben V. C., Cardoso Rodriguez, Ferran, Sufi, Jahangir, Puigdevall Costa, Pau, Subramaniyam, Meera, Kirtsios, Efstratios, Eddaoudi, Ayad, Wu, Si Wei, Guvenel, Aleks, Fisher, Jonathan, Ghorashian, Sara, Pule, Martin A., Tape, Christopher J., Castellano, Sergi, Amrolia, Persis J., Giustacchini, Alice

“…•Low-affinity CAT CAR T cells are characterized by a unique pattern of activation priming and cytokine polyfunctionality.•The enhanced functionality of…”
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The Enhanced Functionality of Low-Affinity CD19 CAR T Cells Is Associated with Activation Priming and Polyfunctional Cytokine Phenotype by Michelozzi, Ilaria M., Gomez-Castaneda, Eduardo, Pohle, Ruben V.C., Cardoso Rodriguez, Ferran, Sufi, Jahangir, Puigdevall, Pau, Subramaniyam, Meera, Wu, Si Wei, Guvenel, Aleks, Ghorashian, Sara, Pule, Martin, Tape, Christopher J., Castellano, Sergi, Amrolia, Persis J, Giustacchini, Alice

“…We have recently described a low-affinity second-generation anti-CD19 Chimeric Antigen Receptor (CAR) (CAT), characterized by faster antigen dissociation rate…”
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