Search Results - "Michelle J. Lin"

De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report by Gandhi, Shiv, Klein, Jonathan, Robertson, Alexander J., Peña-Hernández, Mario A., Lin, Michelle J., Roychoudhury, Pavitra, Lu, Peiwen, Fournier, John, Ferguson, David, Mohamed Bakhash, Shah A. K., Catherine Muenker, M., Srivathsan, Ariktha, Wunder, Elsio A., Kerantzas, Nicholas, Wang, Wenshuai, Lindenbach, Brett, Pyle, Anna, Wilen, Craig B., Ogbuagu, Onyema, Greninger, Alexander L., Iwasaki, Akiko, Schulz, Wade L., Ko, Albert I.

“…SARS-CoV-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. We…”
Get full text

Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets by Cox, Robert M., Wolf, Josef D., Lieber, Carolin M., Sourimant, Julien, Lin, Michelle J., Babusis, Darius, DuPont, Venice, Chan, Julie, Barrett, Kim T., Lye, Diane, Kalla, Rao, Chun, Kwon, Mackman, Richard L., Ye, Chengjin, Cihlar, Tomas, Martinez-Sobrido, Luis, Greninger, Alexander L., Bilello, John P., Plemper, Richard K.

“…Remdesivir is an antiviral approved for COVID-19 treatment, but its wider use is limited by intravenous delivery. An orally bioavailable remdesivir analog may…”
Get full text

VAPiD: a lightweight cross-platform viral annotation pipeline and identification tool to facilitate virus genome submissions to NCBI GenBank by Shean, Ryan C, Makhsous, Negar, Stoddard, Graham D, Lin, Michelle J, Greninger, Alexander L

“…With sequencing technologies becoming cheaper and easier to use, more groups are able to obtain whole genome sequences of viruses of public health and…”
Get full text

Comparative genomics and full-length Tprk profiling of Treponema pallidum subsp. pallidum reinfection by Addetia, Amin, Tantalo, Lauren C, Lin, Michelle J, Xie, Hong, Huang, Meei-Li, Marra, Christina M, Greninger, Alexander L

“…Developing a vaccine against Treponema pallidum subspecies pallidum, the causative agent of syphilis, remains a public health priority. Syphilis vaccine design…”
Get full text

Longitudinal TprK profiling of in vivo and in vitro-propagated Treponema pallidum subsp. pallidum reveals accumulation of antigenic variants in absence of immune pressure by Lin, Michelle J, Haynes, Austin M, Addetia, Amin, Lieberman, Nicole A P, Phung, Quynh, Xie, Hong, Nguyen, Tien V, Molini, Barbara J, Lukehart, Sheila A, Giacani, Lorenzo, Greninger, Alexander L

“…Immune evasion by Treponema pallidum subspecies pallidum (T. pallidum) has been attributed to antigenic variation of its putative outer-membrane protein TprK…”
Get full text

Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the Brain by Mathieu, Cyrille, Bovier, Francesca T, Ferren, Marion, Lieberman, Nicole A P, Predella, Camilla, Lalande, Alexandre, Peddu, Vikas, Lin, Michelle J, Addetia, Amin, Patel, Achchhe, Outlaw, Victor, Corneo, Barbara, Dorrello, N Valerio, Briese, Thomas, Hardie, Diana, Horvat, Branka, Moscona, Anne, Greninger, Alexander L, Porotto, Matteo

“…Measles virus (MeV) bearing a single amino acid change in the fusion protein (F)-L454W-was isolated from two patients who died of MeV central nervous system…”
Get full text

Host–pathogen dynamics in longitudinal clinical specimens from patients with COVID-19 by Lin, Michelle J., Rachleff, Victoria M., Xie, Hong, Shrestha, Lasata, Lieberman, Nicole A. P., Peddu, Vikas, Addetia, Amin, Casto, Amanda M., Breit, Nathan, Mathias, Patrick C., Huang, Meei-Li, Jerome, Keith R., Greninger, Alexander L., Roychoudhury, Pavitra

“…Rapid dissemination of SARS-CoV-2 sequencing data to public repositories has enabled widespread study of viral genomes, but studies of longitudinal specimens…”
Get full text

Sensitive Recovery of Complete SARS-CoV-2 Genomes from Clinical Samples by Use of Swift Biosciences' SARS-CoV-2 Multiplex Amplicon Sequencing Panel by Addetia, Amin, Lin, Michelle J, Peddu, Vikas, Roychoudhury, Pavitra, Jerome, Keith R, Greninger, Alexander L

Get full text

Fragment Size-Based Enrichment of Viral Sequences in Plasma Cell-Free DNA by Phung, Quynh, Lin, Michelle J., Xie, Hong, Greninger, Alexander L.

“…Sequencing of plasma cell-free DNA (cfDNA) is a promising milieu for broad-based cancer and infectious disease diagnostics. The performance of cfDNA sequencing…”
Get full text

A SARS-CoV-2 Nucleocapsid Variant that Affects Antigen Test Performance by Bourassa, Lori, Perchetti, Garrett A., Phung, Quynh, Lin, Michelle J., Mills, Margaret G., Roychoudhury, Pavitra, Harmon, Kimberly G., Reed, Jonathan C., Greninger, Alexander L.

“…•The quidel sofia SARS antigen FIA test (Sofia 2) has an analytical sensitivity of ~54,000 copies/mL.•The sofia 2 had a 1000-fold lower sensitivity for…”
Get full text

Inhibition of Coronavirus Entry In Vitro and Ex Vivo by a Lipid-Conjugated Peptide Derived from the SARS-CoV-2 Spike Glycoprotein HRC Domain by Outlaw, Victor K, Bovier, Francesca T, Mears, Megan C, Cajimat, Maria N, Zhu, Yun, Lin, Michelle J, Addetia, Amin, Lieberman, Nicole A P, Peddu, Vikas, Xie, Xuping, Shi, Pei-Yong, Greninger, Alexander L, Gellman, Samuel H, Bente, Dennis A, Moscona, Anne, Porotto, Matteo

“…The emergence of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), the etiological agent of the 2019 coronavirus disease (COVID-19), has…”
Get full text

Specific allelic discrimination of N501Y and other SARS‐CoV‐2 mutations by ddPCR detects B.1.1.7 lineage in Washington State by Perchetti, Garrett A., Zhu, Haiying, Mills, Margaret G., Shrestha, Lasata, Wagner, Cassia, Bakhash, Shah Mohamed, Lin, Michelle J., Xie, Hong, Huang, Meei‐Li, Mathias, Patrick, Bedford, Trevor, Jerome, Keith R., Greninger, Alexander L., Roychoudhury, Pavitra

“…Real‐time epidemiological tracking of variants of concern (VOCs) can help limit the spread of more contagious forms of severe acute respiratory syndrome…”
Get full text

Human parainfluenza virus evolution during lung infection of immunocompromised individuals promotes viral persistence by Greninger, Alexander L, Rybkina, Ksenia, Lin, Michelle J, Drew-Bear, Jennifer, Marcink, Tara C, Shean, Ryan C, Makhsous, Negar, Boeckh, Michael, Harder, Olivia, Bovier, Francesca, Burstein, Shana R, Niewiesk, Stefan, Rima, Bert K, Porotto, Matteo, Moscona, Anne

“…The capacity of respiratory viruses to undergo evolution within the respiratory tract raises the possibility of evolution under the selective pressure of the…”
Get full text

In vivo generation of BK and JC polyomavirus defective viral genomes in human urine samples associated with higher viral loads by Addetia, Amin, Phung, Quynh, Bradley, Benjamin T, Lin, Michelle, Zhu, Haiying, Xie, Hong, Huang, Meei-Li, Greninger, Alexander L

“…Defective viral genomes (DVGs) are parasitic viral sequences containing point mutations, deletions, or duplications that might interfere with replication. DVGs…”
Get full text

Analysis of SARS-CoV-2 infection dynamic in vivo using reporter-expressing viruses by Ye, Chengjin, Chiem, Kevin, Park, Jun-Gyu, Silvas, Jesus A., Vasquez, Desarey Morales, Sourimant, Julien, Lind, Michelle J., Greninger, Alexander L., Plemper, Richard K., Torrelles, Jordi B., Kobie, James J., Walter, Mark R., de la Torre, Juan Carlos, Martinez-Sobrido, Luis

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the current COVID-19 pandemic, is one of the biggest threats to public…”
Get full text

Estimation of Full-Length TprK Diversity in Treponema pallidum subsp. pallidum by Addetia, Amin, Lin, Michelle J, Phung, Quynh, Xie, Hong, Huang, Meei-Li, Ciccarese, Giulia, Dal Conte, Ivano, Cusini, Marco, Drago, Francesco, Giacani, Lorenzo, Greninger, Alexander L

“…Immune evasion and disease progression of subsp. are associated with sequence diversity in the hypervariable outer membrane protein TprK. Previous attempts to…”
Get full text

A Bifluorescent-Based Assay for the Identification of Neutralizing Antibodies against SARS-CoV-2 Variants of Concern In Vitro and In Vivo by Chiem, Kevin, Morales Vasquez, Desarey, Silvas, Jesus A, Park, Jun-Gyu, Piepenbrink, Michael S, Sourimant, Julien, Lin, Michelle J, Greninger, Alexander L, Plemper, Richard K, Torrelles, Jordi B, Walter, Mark R, de la Torre, Juan C, Kobie, James K, Ye, Chengjin, Martinez-Sobrido, Luis

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged at the end of 2019 and has been responsible for the still ongoing coronavirus disease 2019…”
Get full text

Clinical Performance Characteristics of the Swift Normalase Amplicon Panel for Sensitive Recovery of Severe Acute Respiratory Syndrome Coronavirus 2 Genomes by Shrestha, Lasata, Lin, Michelle J, Xie, Hong, Mills, Margaret G, Mohamed Bakhash, Shah A, Gaur, Vinod P, Livingston, Robert J, Castor, Jared, Bruce, Emily A, Botten, Jason W, Huang, Meei-Li, Jerome, Keith R, Greninger, Alexander L, Roychoudhury, Pavitra

“…Amplicon-based sequencing methods are central in characterizing the diversity, transmission, and evolution of severe acute respiratory syndrome coronavirus 2…”
Get full text

Orally efficacious broad-spectrum allosteric inhibitor of paramyxovirus polymerase by Cox, Robert M., Sourimant, Julien, Toots, Mart, Yoon, Jeong-Joong, Ikegame, Satoshi, Govindarajan, Mugunthan, Watkinson, Ruth E., Thibault, Patricia, Makhsous, Negar, Lin, Michelle J., Marengo, Jose R., Sticher, Zachary, Kolykhalov, Alexander A., Natchus, Michael G., Greninger, Alexander L., Lee, Benhur, Plemper, Richard K.

“…Paramyxoviruses such as human parainfluenza virus type-3 (HPIV3) and measles virus (MeV) are a substantial health threat. In a high-throughput screen for…”
Get full text

Treponema pallidum genome sequencing from six continents reveals variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar by Lieberman, Nicole A P, Lin, Michelle J, Xie, Hong, Shrestha, Lasata, Nguyen, Tien, Huang, Meei-Li, Haynes, Austin M, Romeis, Emily, Wang, Qian-Qiu, Zhang, Rui-Li, Kou, Cai-Xia, Ciccarese, Giulia, Dal Conte, Ivano, Cusini, Marco, Drago, Francesco, Nakayama, Shu-Ichi, Lee, Kenichi, Ohnishi, Makoto, Konda, Kelika A, Vargas, Silver K, Eguiluz, Maria, Caceres, Carlos F, Klausner, Jeffrey D, Mitjà, Oriol, Rompalo, Anne, Mulcahy, Fiona, Hook, 3rd, Edward W, Lukehart, Sheila A, Casto, Amanda M, Roychoudhury, Pavitra, DiMaio, Frank, Giacani, Lorenzo, Greninger, Alexander L

“…In spite of its immutable susceptibility to penicillin, Treponema pallidum (T. pallidum) subsp. pallidum continues to cause millions of cases of syphilis each…”
Get full text