Search Results - "Michell, R H"
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Identification of ARAP3, a Novel PI3K Effector Regulating Both Arf and Rho GTPases, by Selective Capture on Phosphoinositide Affinity Matrices
Published in Molecular cell (2002)“…We show that matrices carrying the tethered homologs of natural phosphoinositides can be used to capture and display multiple phosphoinositide binding proteins…”
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Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis
Published in Nature (London) (13-11-1997)“…Inositol phospholipids play multiple roles in cell signalling systems. Two widespread eukaryotic phosphoinositide-based signal transduction mechanisms,…”
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Inhibition of phosphatases and increased Ca2+ channel activity by inositol hexakisphosphate
Published in Science (American Association for the Advancement of Science) (17-10-1997)“…Inositol hexakisphosphate (InsP6), the dominant inositol phosphate in insulin-secreting pancreatic beta cells, inhibited the serine-threonine protein…”
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The effects of thimerosal on calcium uptake and inositol 1,4,5-trisphosphate-induced calcium release in cerebellar microsomes
Published in Biochemical journal (01-02-1993)“…Thimerosal inhibits calcium uptake in skeletal muscle sarcoplasmic reticulum and rat cerebellar microsomes by inhibiting the Ca(2+)-ATPase. In the presence of…”
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The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane
Published in Biochemical journal (01-04-1982)“…Human erythrocyte ghosts exhibit an inositol trisphosphate phosphomonoesterase activity that rapidly converts inositol 1,4,5-trisphosphate into inositol…”
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Estrogenic alkylphenols induce cell death by inhibiting testis endoplasmic reticulum Ca(2+) pumps
Published in Biochemical and biophysical research communications (02-11-2000)“…Industrial alkylphenols in the environment may act as "xenoestrogens" to disrupt testicular development and decrease male fertility. Amongst possible targets…”
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Comparison of the levels of inositol metabolites in transformed haemopoietic cells and their normal counterparts
Published in Biochemical journal (01-02-1993)“…We have compared the levels of inositol metabolites in three pairs of normal and transformed cells which have been matched with respect to their cell lineage,…”
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Rapid accumulation of inositol phosphates in isolated rat superior cervical sympathetic ganglia exposed to V1-vasopressin and muscarinic cholinergic stimuli
Published in Biochemical journal (01-08-1984)“…An accumulation of 3H-labelled inositol phosphates is observed when prelabelled rat superior cervical sympathetic ganglia are exposed to…”
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The Stimulation of Inositol Lipid Metabolism that Accompanies Calcium Mobilization in Stimulated Cells: Defined Characteristics and Unanswered Questions
Published in Philosophical transactions of the Royal Society of London. Series B, Biological sciences (18-12-1981)“…It now appears to be generally agreed that the `phosphatidylinositol response', discovered in 1953 by Hokin & Hokin, occurs universally when cells are…”
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Pasteurella multocida toxin, a potent mitogen, increases inositol 1,4,5-trisphosphate and mobilizes Ca2+ in Swiss 3T3 cells
Published in The Journal of biological chemistry (15-03-1991)“…Pasteurella multocida toxin, both native and recombinant, is an extremely potent mitogen for Swiss 3T3 cells and acts to enhance the formation of total…”
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The polyphosphoinositide phosphodiesterase of erythrocyte membranes
Published in Biochemical journal (15-07-1981)“…1. A new assay procedure has been devised for measurement of the Ca(2+)-activated polyphosphoinositide phosphodiesterase (phosphatidylinositol polyphosphate…”
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The inositol phosphates in WRK1 rat mammary tumor cells
Published in Biochemical journal (01-09-1992)“…1. A detailed structural survey has been made of the inositol phosphates of unstimulated and vasopressin-stimulated WRK-1 rat mammary tumour cells. Inositol…”
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Stepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liver
Published in Nature (London) (01-01-1984)“…Many receptors for hormones, neurotransmitters and other signals cause hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and effect a rise in…”
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Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01-06-1998)“…In eukaryotes, many receptor agonists use phospholipase-generated lipids as intracellular messengers. Receptor occupation stimulates the production of…”
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The interrelationships of the inositol phosphates formed in vasopressin-stimulated WRK-1 rat mammary tumour cells
Published in Biochemical journal (01-09-1992)“…1. Temporal changes in the levels of many inositol phosphates, whose structural characterization is presented in the preceding paper [Wong, Barker, Morris,…”
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Phosphatidylinositol 3,5-bisphosphate: a novel lipid that links stress responses to membrane trafficking events
Published in Biochemical Society transactions (01-08-1999)Get more information
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The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae
Published in Current biology (05-11-1998)“…Polyphosphoinositides have many roles in cell signalling and vesicle trafficking [1–3]. Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2), a recently…”
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Inositol Lipids: Receptor-Stimulated Hydrolysis and Cellular Lipid Pools
Published in Philosophical transactions of the Royal Society of London. Series B, Biological sciences (26-07-1988)“…Our current knowledge of the process by which receptors stimulate the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) has its origin in the…”
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Post-receptor signalling pathways
Published in The Lancet (British edition) (08-04-1989)Get more information
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