Dietary cyanidin 3-glucoside from purple corn ameliorates doxorubicin-induced cardiotoxicity in mice

Abstract Background and aims Anthracyclines are effective anticancer drugs that have improved prognosis of hundred thousand cancer patients worldwide and are currently the most common chemotherapeutic agents used for the treatment of blood, breast, ovarian and lung cancers. However, their use is lim...

Full description

Saved in:

Bibliographic Details
Published in:	Nutrition, metabolism, and cardiovascular diseases Vol. 27; no. 5; pp. 462 - 469
Main Authors:	Petroni, K, Trinei, M, Fornari, M, Calvenzani, V, Marinelli, A, Micheli, L.A, Pilu, R, Matros, A, Mock, H.-P, Tonelli, C, Giorgio, M
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-05-2017
Subjects:	Animal Feed Animals Anthocyanins Anthocyanins - isolation & purification Anthocyanins - pharmacology Cardioprotection Cardiotoxicity Cardiovascular Cell Survival - drug effects Cytoprotection Diet Disease Models, Animal Dose-Response Relationship, Drug Doxorubicin Female Gene Expression Regulation Glucosides - isolation & purification Glucosides - pharmacology Heart Diseases - chemically induced Heart Diseases - metabolism Heart Diseases - pathology Heart Diseases - prevention & control HeLa Cells Humans MCF-7 Cells Mice, Inbred C57BL Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Phytotherapy Plant Extracts - isolation & purification Plant Extracts - pharmacology Plants, Medicinal Protective Agents - isolation & purification Protective Agents - pharmacology Purple corn Time Factors Zea mays - chemistry Anthocyanins Cardioprotection Doxorubicin Purple corn
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Abstract Background and aims Anthracyclines are effective anticancer drugs that have improved prognosis of hundred thousand cancer patients worldwide and are currently the most common chemotherapeutic agents used for the treatment of blood, breast, ovarian and lung cancers. However, their use is limited because of a cumulative dose-dependent and irreversible cardiotoxicity that can cause progressive cardiomyopathy and congestive heart failure. Aim of the present study was to determine the cardioprotective activity of a dietary source of cyanidin 3-glucoside (C3G), such as purple corn, against doxorubicin (DOX)-induced cardiotoxicity in mice. Methods and results In vitro studies on murine HL-1 cardiomyocytes showed that pretreatment with both pure C3G and purple corn extract improved survival upon DOX treatment. However, C3G and purple corn extract did not affect the cytotoxic effect of DOX on human cancer cell lines. We then validated in vivo the protective role of a C3G-enriched diet against DOX-induced cardiotoxicity by comparing the effect of dietary consumption of corn isogenic lines with high levels of anthocyanins (purple corn – Red diet – RD) or without anthocyanins (yellow corn – Yellow diet – YD) incorporated in standard rodent diets. Results showed that mice fed RD survived longer than mice fed YD upon injection of a toxic amount of DOX. In addition, ultrastructural analysis of hearts from mice fed RD showed reduced histopathological alterations. Conclusion Dietary intake of C3G from purple corn protects mice against DOX-induced cardiotoxicity.
ISSN:	0939-4753 1590-3729
DOI:	10.1016/j.numecd.2017.02.002