Search Results - "Michelhaugh, Sharon"

The aryl hydrocarbon receptor is a tumor suppressor–like gene in glioblastoma by Jin, Un-Ho, Karki, Keshav, Cheng, Yating, Michelhaugh, Sharon K., Mittal, Sandeep, Safe, Stephen

“…The aryl hydrocarbon receptor (AhR) plays an important role in maintaining cellular homeostasis and also in pathophysiology. For example, the interplay between…”
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Protein Expression and Functional Relevance of Efflux and Uptake Drug Transporters at the Blood–Brain Barrier of Human Brain and Glioblastoma by Bao, Xun, Wu, Jianmei, Xie, Youming, Kim, Seongho, Michelhaugh, Sharon, Jiang, Jun, Mittal, Sandeep, Sanai, Nader, Li, Jing

“…The knowledge of transporter protein expression and function at the human blood–brain barrier (BBB) is critical to prediction of drug BBB penetration and…”
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Mining Affymetrix microarray data for long non-coding RNAs: altered expression in the nucleus accumbens of heroin abusers by Michelhaugh, Sharon K, Lipovich, Leonard, Blythe, Jason, Jia, Hui, Kapatos, Gregory, Bannon, Michael J

“…J. Neurochem. (2011) 116, 459-466. ABSTRACT: Although recent data suggest that some long non-coding RNAs (lncRNAs) exert widespread effects on gene expression…”
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Alternating electric tumor treating fields for treatment of glioblastoma: rationale, preclinical, and clinical studies by Mittal, Sandeep, Klinger, Neil V, Michelhaugh, Sharon K, Barger, Geoffrey R, Pannullo, Susan C, Juhász, Csaba

“…OBJECTIVE Treatment for glioblastoma (GBM) remains largely unsuccessful, even with aggressive combined treatment via surgery, radiotherapy, and chemotherapy…”
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Comparison of Amino Acid Positron Emission Tomographic Radiotracers for Molecular Imaging of Primary and Metastatic Brain Tumors by Juhász, Csaba, Dwivedi, Shalini, Kamson, David O., Michelhaugh, Sharon K., Mittal, Sandeep

“…Positron emission tomography (PET) is an imaging technology that can detect and characterize tumors based on their molecular and biochemical properties, such…”
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Dopamine is an aryl hydrocarbon receptor agonist by Park, Hyejin, Jin, Un-Ho, Karki, Keshav, Jayaraman, Arul, Allred, Clint, Michelhaugh, Sharon K, Mittal, Sandeep, Chapkin, Robert S, Safe, Stephen

“…Tryptophan metabolites exhibit aryl hydrocarbon receptor (AhR) agonist activity and recent studies show that the phenylalanine metabolites serotonin and…”
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GNAQ Mutation in the Venous Vascular Malformation and Underlying Brain Tissue in Sturge-Weber Syndrome by Sundaram, Senthil K, Michelhaugh, Sharon K, Klinger, Neil V, Kupsky, William J, Sood, Sandeep, Chugani, Harry T, Mittal, Sandeep, Juhász, Csaba

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Nuclear receptor 4A2 (NR4A2) is a druggable target for glioblastomas by Karki, Keshav, Li, Xi, Jin, Un-Ho, Mohankumar, Kumaravel, Zarei, Mahsa, Michelhaugh, Sharon K., Mittal, Sandeep, Tjalkens, Ronald, Safe, Stephen

“…Introduction The orphan nuclear receptor 4A2 (NR4A2) has been extensively characterized in subcellular regions of the brain and is necessary for the function…”
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Multimodal imaging-defined subregions in newly diagnosed glioblastoma: impact on overall survival by John, Flóra, Bosnyák, Edit, Robinette, Natasha L, Amit-Yousif, Alit J, Barger, Geoffrey R, Shah, Keval D, Michelhaugh, Sharon K, Klinger, Neil V, Mittal, Sandeep, Juhász, Csaba

“…Abstract Background Although glioblastomas are heterogeneous brain-infiltrating tumors, their treatment is mostly focused on the contrast-enhancing tumor mass…”
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Gliosarcoma vs. glioblastoma: a retrospective case series using molecular profiling by Dardis, Christopher, Donner, David, Sanai, Nader, Xiu, Joanne, Mittal, Sandeep, Michelhaugh, Sharon K, Pandey, Manjari, Kesari, Santosh, Heimberger, Amy B, Gatalica, Zoran, Korn, Michael W, Sumrall, Ashley L, Phuphanich, Surasak

“…Abstract Background Gliosarcoma (GS) refers to the presence of mesenchymal differentiation (as seen using light microscopy) in the setting of glioblastoma (GB,…”
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Omeprazole Inhibits Glioblastoma Cell Invasion and Tumor Growth by Jin, Un-Ho, Michelhaugh, Sharon K., Polin, Lisa A., Shrestha, Rupesh, Mittal, Sandeep, Safe, Stephen

“…Background: The aryl hydrocarbon receptor (AhR) is expressed in gliomas and the highest staining is observed in glioblastomas. A recent study showed that the…”
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Investigation of the aryl hydrocarbon receptor and the intrinsic tumoral component of the kynurenine pathway of tryptophan metabolism in primary brain tumors by Guastella, Anthony R., Michelhaugh, Sharon K., Klinger, Neil V., Fadel, Hassan A., Kiousis, Sam, Ali-Fehmi, Rouba, Kupsky, William J., Juhász, Csaba, Mittal, Sandeep

“…Introduction There is mounting evidence supporting the role of tryptophan metabolism via the kynurenine pathway (KP) in the pathogenesis of primary brain…”
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3D models of glioblastoma interaction with cortical cells by Abedin, Md Joynal, Michelhaugh, Sharon K, Mittal, Sandeep, Berdichevsky, Yevgeny

“…Glioblastoma (GBM) invasiveness and ability to infiltrate deep into the brain tissue is a major reason for the poor patient prognosis for this type of brain…”
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[89Zr]ZrDFO-CR011 PET Correlates with Response to Glycoprotein Nonmetastatic Melanoma B-targeted Therapy in Triple-negative Breast Cancer by Lee, Supum, Cavaliere, Alessandra, Gallezot, Jean-Dominique, Keler, Tibor, Michelhaugh, Sharon K, Belitzky, Erika, Liu, Michael, Mulnix, Tim, Maher, Stephen E, Bothwell, Alfred L M, Li, Fangyong, Phadke, Manali, Mittal, Sandeep, Marquez-Nostra, Bernadette

“…There is a need for prognostic markers to select patients most likely to benefit from antibody-drug conjugate (ADC) therapy. We quantified the relationship…”
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Depression and tryptophan metabolism in patients with primary brain tumors: Clinical and molecular imaging correlates by John, Flóra, Michelhaugh, Sharon K., Barger, Geoffrey R., Mittal, Sandeep, Juhász, Csaba

“…Patients with brain tumors have an increased risk for depression, whose underlying pathomechanism may involve dysregulated tryptophan/kynurenine metabolism. In…”
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Cytogenomic profiling of breast cancer brain metastases reveals potential for repurposing targeted therapeutics by Bollig-Fischer, Aliccia, Michelhaugh, Sharon K, Wijesinghe, Priyanga, Dyson, Greg, Kruger, Adele, Palanisamy, Nallasivam, Choi, Lydia, Alosh, Baraa, Ali-Fehmi, Rouba, Mittal, Sandeep

“…Breast cancer brain metastases remain a significant clinical problem. Chemotherapy is ineffective and a lack of treatment options result in poor patient…”
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Correction to: Gliosarcoma vs. glioblastoma: a retrospective case series using molecular profiling by Dardis, Christopher, Donner, David, Sanai, Nader, Xiu, Joanne, Mittal, Sandeep, Michelhaugh, Sharon K, Pandey, Manjari, Kesari, Santosh, Heimberger, Amy B, Gatalica, Zoran, Korn, Michael W, Sumrall, Ashley L, Phuphanich, Surasak

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Preferential expression of functional IL-17R in glioma stem cells: potential role in self-renewal by Parajuli, Prahlad, Anand, Rohit, Mandalaparty, Chandramouli, Suryadevara, Raviteja, Sriranga, Preethi U, Michelhaugh, Sharon K, Cazacu, Simona, Finniss, Susan, Thakur, Archana, Lum, Lawrence G, Schalk, Dana, Brodie, Chaya, Mittal, Sandeep

“…Gliomas are the most common primary brain tumor and one of the most lethal solid tumors. Mechanistic studies into identification of novel biomarkers are needed…”
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A Molecular Profile of Cocaine Abuse Includes the Differential Expression of Genes that Regulate Transcription, Chromatin, and Dopamine Cell Phenotype by BANNON, Michael J, JOHNSON, Magen M, MICHELHAUGH, Sharon K, HARTLEY, Zachary J, HALTER, Steven D, DAVID, James A, KAPATOS, Gregory, SCHMIDT, Carl J

“…Chronic drug abuse, craving, and relapse are thought to be linked to long-lasting changes in neural gene expression arising through transcriptional and…”
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Acute or chronic use of lacosamide does not alter its distribution between serum and cerebrospinal fluid by Michelhaugh, Sharon K., Basha, Maysaa, Rhoney, Denise H., Shah, Aashit K., Mittal, Sandeep

“…Summary Objective The site of action for antiepileptic drugs (AEDs) is within the brain; however, cerebrospinal fluid (CSF) concentration is highly variable…”
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