Search Results - "Michel, Annika"
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Cellular adaptation of Clostridioides difficile to high salinity encompasses a compatible solute‐responsive change in cell morphology
Published in Environmental microbiology (01-03-2022)“…Summary Infections by the pathogenic gut bacterium Clostridioides difficile cause severe diarrhoeas up to a toxic megacolon and are currently among the major…”
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Influence of L-lactate and low glucose concentrations on the metabolism and the toxin formation of Clostridioides difficile
Published in PloS one (07-01-2021)“…The virulence of Clostridioides difficile (formerly Clostridium difficile) is mainly caused by its two toxins A and B. Their formation is significantly…”
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Metabolic Reprogramming of Clostridioides difficile During the Stationary Phase With the Induction of Toxin Production
Published in Frontiers in microbiology (21-08-2018)“…The obligate anaerobe, spore forming bacterium (formerly ) causes nosocomial and community acquired diarrhea often associated with antibiotic therapy. Major…”
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Iron Regulation in Clostridioides difficile
Published in Frontiers in microbiology (24-12-2018)“…The response to iron limitation of several bacteria is regulated by the ferric uptake regulator (Fur). The Fur-regulated transcriptional, translational and…”
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Quality Control by Isoleucyl-tRNA Synthetase of Bacillus subtilis Is Required for Efficient Sporulation
Published in Scientific reports (31-01-2017)“…Isoleucyl-tRNA synthetase (IleRS) is an aminoacyl-tRNA synthetase whose essential function is to aminoacylate tRNA Ile with isoleucine. Like some other…”
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Clostridioides difficile Activates Human Mucosal-Associated Invariant T Cells
Published in Frontiers in microbiology (25-10-2018)“…infection (CDI) causes severe inflammatory responses at the intestinal mucosa but the immunological mechanisms underlying CDI-related immunopathology are still…”
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A Point Mutation in the Transcriptional Repressor PerR Results in a Constitutive Oxidative Stress Response in Clostridioides difficile 630Δ erm
Published in mSphere (03-03-2021)“…The human pathogen has evolved into the leading cause of nosocomial diarrhea. The bacterium is capable of spore formation, which even allows survival of…”
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Redefining the Clostridioides difficile σ B Regulon: σ B Activates Genes Involved in Detoxifying Radicals That Can Result from the Exposure to Antimicrobials and Hydrogen Peroxide
Published in mSphere (16-09-2020)“…Sigma B is the alternative sigma factor governing stress response in many Gram-positive bacteria. In C. difficile , a sigB mutant shows pleiotropic…”
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A Novel MATLAB®-Algorithm-Based Video Analysis to Quantitatively Determine Solution Creeping in Intact Pharmaceutical Glass Vials
Published in European journal of pharmaceutics and biopharmaceutics (01-09-2022)“…[Display omitted] During the filling process of a biopharmaceutical drug product (DP), a liquid DP film might creep up the inner vial wall which is barely…”
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