Search Results - "Michaud, Edward J"

The primary cilium in cell signaling and cancer by Michaud, Edward J, Yoder, Bradley K

“…The primary cilium is a microtubule-based antenna-like structure that emanates from the surface of virtually all cells in the mammalian body. It is anchored to…”
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Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function by Haycraft, Courtney J, Banizs, Boglarka, Aydin-Son, Yesim, Zhang, Qihong, Michaud, Edward J, Yoder, Bradley K

“…Intraflagellar transport (IFT) proteins are essential for cilia assembly and have recently been associated with a number of developmental processes, such as…”
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The Oak Ridge Polycystic Kidney mouse: Modeling ciliopathies of mice and men by Lehman, Jonathan M., Michaud, Edward J., Schoeb, Trenton R., Aydin‐Son, Yesim, Miller, Michael, Yoder, Bradley K.

“…The Oak Ridge Polycystic Kidney (ORPK) mouse was described nearly 14 years ago as a model for human recessive polycystic kidney disease. The ORPK mouse arose…”
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Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation by Berbari, Nicolas F., Kin, Nicholas W., Sharma, Neeraj, Michaud, Edward J., Kesterson, Robert A., Yoder, Bradley K.

“…Tumor necrosis factor alpha receptor 3 interacting protein 1 (Traf3ip1), also known as MIPT3, was initially characterized through its interactions with…”
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Role of epidermal primary cilia in the homeostasis of skin and hair follicles by Croyle, Mandy J, Lehman, Jonathan M, O'Connor, Amber K, Wong, Sunny Y, Malarkey, Erik B, Iribarne, Daniela, Dowdle, William E, Schoeb, Trenton R, Verney, Zoe M, Athar, Mohammad, Michaud, Edward J, Reiter, Jeremy F, Yoder, Bradley K

“…Skin and hair follicle morphogenesis and homeostasis require the integration of multiple signaling pathways, including Hedgehog (Hh) and Wingless (Wnt), and…”
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An Essential Role for Dermal Primary Cilia in Hair Follicle Morphogenesis by Lehman, Jonathan M., Laag, Essam, Michaud, Edward J., Yoder, Bradley K.

“…The primary cilium is a microtubule-based organelle implicated as an essential component of a number of signaling pathways. It is present on cells throughout…”
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Functional redundancy of the B9 proteins and nephrocystins in Caenorhabditis elegans ciliogenesis by Williams, Corey L, Winkelbauer, Marlene E, Schafer, Jenny C, Michaud, Edward J, Yoder, Bradley K

“…Meckel-Gruber syndrome (MKS), nephronophthisis (NPHP), and Joubert syndrome (JBTS) are a group of heterogeneous cystic kidney disorders with partially…”
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Loss of the Tg737 protein results in skeletal patterning defects by Zhang, Qihong, Murcia, Noel S., Chittenden, Laura R., Richards, William G., Michaud, Edward J., Woychik, Richard P., Yoder, Bradley K.

“…Tg737 mutant mice exhibit pathologic conditions in numerous tissues along with skeletal patterning defects. Herein, we characterize the skeletal pathologic…”
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Molecular and Phenotypic Analysis of 25 Recessive, Homozygous-Viable Alleles at the Mouse agouti Locus by Miltenberger, Rosalynn J, Wakamatsu, Kazumasa, Ito, Shosuke, Woychik, Richard P, Russell, Liane B, Michaud, Edward J

“…Agouti is a paracrine-acting, transient antagonist of melanocortin 1 receptors that specifies the subapical band of yellow on otherwise black hairs of the…”
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The Near-Naked Hairless (HrN) Mutation Disrupts Hair Formation but Is Not Due to a Mutation in the Hairless Coding Region by Liu, Yutao, Das, Suchita, Olszewski, Robert E., Carpenter, Donald A., Culiat, Cymbeline T., Sundberg, John P., Soteropoulos, Patricia, Liu, Xiaochen, Doktycz, Mitchel J., Michaud, Edward J., Voy, Brynn H.

“…Near-naked hairless (HrN) is a semi-dominant, spontaneous mutation that was suggested by allelism testing to be allelic with mouse Hairless (Hr). HrN mice…”
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Cloning, functional study and comparative mapping of Luzp2 to mouse chromosome 7 and human chromosome 11p13-11p14 by Wu, Min, Michaud, Edward J, Johnson, Dabney K

“…A novel leucine-zipper gene, leucine zipper protein 2 (Luzp2), has been cloned as part of an aberrant deletion-fusion transcript in the chromosomal interval…”
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Liver-specific expression of the agouti gene in transgenic mice promotes liver carcinogenesis in the absence of obesity and diabetes by Kuklin, Alexander I, Mynatt, Randall L, Klebig, Mitchell L, Kiefer, Laura L, Wilkison, William O, Woychik, Richard P, Michaud, Edward J

“…The agouti protein is a paracrine factor that is normally present in the skin of many species of mammals. Agouti regulates the switch between black and yellow…”
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A Targeted Deleterious Allele of the Splicing Factor SCNM1 in the Mouse by Howell, Viive M, de Haan, Georgius, Bergren, Sarah, Jones, Julie M, Culiat, Cymbeline T, Michaud, Edward J, Frankel, Wayne N, Meisler, Miriam H

“…The auxiliary spliceosomal protein SCNM1 contributes to recognition of nonconsensus splice donor sites. SCNM1 was first identified as a modifier of the…”
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Role of epidermal primary cilia in the homeostasis of skin and hair follicles by Croyle, Mandy J., Lehman, Jonathan M., O'Connor, Amber K., Wong, Sunny Y., Malarkey, Erik B., Iribarne, Daniela, Dowdle, William E., Schoeb, Trenton R., Verney, Zoe M., Athar, Mohammad, Michaud, Edward J., Reiter, Jeremy F., Yoder, Bradley K.

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Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice by Michaud, Edward J, Culiat, Cymbeline T, Klebig, Mitchell L, Barker, Paul E, Cain, K T, Carpenter, Debra J, Easter, Lori L, Foster, Carmen M, Gardner, Alysyn W, Guo, Z Y, Houser, Kay J, Hughes, Lori A, Kerley, Marilyn K, Liu, Zhaowei, Olszewski, Robert E, Pinn, Irina, Shaw, Ginger D, Shinpock, Sarah G, Wymore, Ann M, Rinchik, Eugene M, Johnson, Dabney K

“…Analysis of an allelic series of point mutations in a gene, generated by N-ethyl-N-nitrosourea (ENU) mutagenesis, is a valuable method for discovering the full…”
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A Molecular Model for the Genetic and Phenotypic Characteristics of the Mouse Lethal Yellow (Ay) Mutation by Michaud, Edward J., Bultman, Scott J., Klebig, Mitchell L., Van Vugt, Martine J., Stubbs, Lisa J., Russell, Liane B., Woychik, Richard P.

“…Lethal yellow (Ay) is a mutation at the mouse agouti locus in chromosome 2 that causes a number of dominant pleiotropic effects, including a completely yellow…”
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Agouti regulation of intracellular calcium: role in the insulin resistance of viable yellow mice by Zemel, M.B. (University of Tennessee, Knoxville, TN.), Kim, J.H, Woychik, R.P, Michaud, E.J, Kadwell, S.H, Patel, I.R, Wilkison, W.O

“…Several dominant mutations at the agouti locus in the mouse cause a syndrome of marked obesity, hyperinsulinemia, and insulin resistance. Although it is known…”
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Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice by Johnson, Dabney K, Rinchik, Eugene M, Moustaid-Moussa, Naima, Miller, Darla R, Williams, Robert W, Michaud, Edward J, Jablonski, Monica M, Elberger, Andrea, Hamre, Kristen, Smeyne, Richard, Chesler, Elissa, Goldowitz, Daniel

“…With the goal of discovering genes that contribute to late-onset neurological and ocular disorders and also genes that extend the healthy life span in mammals,…”
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Geographic Variation in the Life History of the Lizard Anolis carolinensis and Support for the Pelvic Constraint Model by Michaud, Edward J., Echternacht, Arthur C.

“…The green anole (Anolis carolinensis) occurs throughout the southeastern United States and its distribution defines the northern limit of the range of this…”
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Alternative processing of the human and mouse Raly genes by Khrebtukova, Irina, Kuklin, Alexander, Woychik, Richard P, Michaud, Edward J

“…A human homolog (RALY) of the mouse Raly gene was isolated and sequenced, and shown to encode a novel protein isoform containing a 16 amino acid in-frame…”
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