Search Results - "Michalski, Megan N."

Modulation of Osteoblastic Cell Efferocytosis by Bone Marrow Macrophages by Michalski, Megan N., Koh, Amy J., Weidner, Savannah, Roca, Hernan, McCauley, Laurie K.

“…ABSTRACT Apoptosis occurs at an extraordinary rate in the human body and the effective clearance of dead cells (efferocytosis) is necessary to maintain…”
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The Past, Present, and Future of Genetically Engineered Mouse Models for Skeletal Biology by Michalski, Megan N, Williams, Bart O

“…The ability to create genetically engineered mouse models (GEMMs) has exponentially increased our understanding of many areas of biology. Musculoskeletal…”
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Macrophages and skeletal health by Michalski, Megan N, McCauley, Laurie K

“…Bone is in a constant state of remodeling, a process which was once attributed solely to osteoblasts and osteoclasts. Decades of research has identified many…”
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Parathyroid hormone mediates hematopoietic cell expansion through interleukin-6 by Pirih, Flavia Q, Michalski, Megan N, Cho, Sun W, Koh, Amy J, Berry, Janice E, Ghaname, Eduardo, Kamarajan, Pachiyappan, Bonnelye, Edith, Ross, Charles W, Kapila, Yvonne L, Jurdic, Pierre, McCauley, Laurie K

“…Parathyroid hormone (PTH) stimulates hematopoietic cells through mechanisms of action that remain elusive. Interleukin-6 (IL-6) is upregulated by PTH and…”
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Proteoglycan 4, a Novel Immunomodulatory Factor, Regulates Parathyroid Hormone Actions on Hematopoietic Cells by Novince, Chad M, Koh, Amy J, Michalski, Megan N, Marchesan, Julie T, Wang, Jason, Jung, Younghun, Berry, Janice E, Eber, Matthew R, Rosol, Thomas J, Taichman, Russell S, McCauley, Laurie K

“…Proteoglycan 4 (PRG4), a critical protective factor in articular joints, is implicated in hematopoietic progenitor cell expansion and megakaryopoiesis. PRG4…”
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Regulation of Wnt receptor activity: Implications for therapeutic development in colon cancer by Zhong, Zhendong A., Michalski, Megan N., Stevens, Payton D., Sall, Emily A., Williams, Bart O.

“…Hyperactivation of Wnt/β-catenin (canonical) signaling in colorectal cancers (CRCs) was identified in the 1990s. Most CRC patients have mutations in genes that…”
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Frizzled‐4 is required for normal bone acquisition despite compensation by Frizzled‐8 by Kushwaha, Priyanka, Kim, Soohyun, Foxa, Gabrielle E., Michalski, Megan N., Williams, Bart O., Tomlinson, Ryan E., Riddle, Ryan C.

“…The activation of the Wnt/β‐catenin signaling pathway is critical for skeletal development but surprisingly little is known about the requirements for the…”
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Anabolic actions of parathyroid hormone in a hypophosphatasia mouse model by Koh, Amy J, Nam, Hwa Kyung, Michalski, Megan N, Do, Justin, McCauley, Laurie K, Hatch, Nan E

“…Summary Hypophosphatasia, the rare heritable disorder caused by TNAP enzyme mutations, presents wide-ranging severity of bone hypomineralization and skeletal…”
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A quest for clarity in bone erosion: The role of sequestosome 1 in Paget's disease of bone by Michalski, Megan N., Williams, Bart O.

“…Alterations in the SQSTM1 gene are a putative cause of Paget’s disease of bone, yet results are conflicting about how these mutations impact osteoclasts, the…”
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Successful therapeutic intervention in new mouse models of frizzled 2-associated congenital malformations by Liegel, Ryan P, Michalski, Megan N, Vaidya, Sanika, Bittermann, Elizabeth, Finnerty, Erin, Menke, Chelsea A, Diegel, Cassandra R, Zhong, Zhendong A, Williams, Bart O, Stottmann, Rolf W

“…Frizzled 2 (FZD2) is a transmembrane Wnt receptor. We previously identified a pathogenic human FZD2 variant in individuals with FZD2-associated autosomal…”
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Bone Mass Is Compromised by the Chemotherapeutic Trabectedin in Association With Effects on Osteoblasts and Macrophage Efferocytosis by Sinder, Benjamin P, Zweifler, Laura, Koh, Amy J, Michalski, Megan N, Hofbauer, Lorenz C, Aguirre, Jose Ignacio, Roca, Hernan, McCauley, Laurie K

“…ABSTRACT Macrophages have established roles supporting bone formation. Despite their professional phagocytic nature, the role of macrophage phagocytosis in…”
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Inflammatory bone loss associated with MFG‐E8 deficiency is rescued by teriparatide by Michalski, Megan N., Seydel, Anna L., Siismets, Erica M., Zweifler, Laura E., Koh, Amy J., Sinder, Benjamin P., Aguirre, J. Ignacio, Atabai, Kamran, Roca, Hernan, McCauley, Laurie K.

“…A prolonged increase in proinflammatory cytokines is associated with osteoporotic and autoimmune bone loss and, conversely, anti‐inflammatory pathways are…”
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β-catenin-dependent High Bone Mass Induced by Loss of APC in Osteoblasts Does Not Require Lrp5 or Lrp6 by Diegel, Cassandra R, Michalski, Megan N, Williams, Bart O

“…The requirement for LRP5 and LRP6 to prevent β-catenin degradation in the absence of the tumor suppressor APC is unclear because cell culture models have…”
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Got WNTS? Insight into bone health from a WNT perspective by Craig, Sonya E L, Michalski, Megan N, Williams, Bart O

“…WNT signaling, essential for many aspects of development, is among the most commonly altered pathways associated with human disease. While initially studied in…”
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Proteoglycan 4: A dynamic regulator of skeletogenesis and parathyroid hormone skeletal anabolism by Novince, Chad M, Michalski, Megan N, Koh, Amy J, Sinder, Benjamin P, Entezami, Payam, Eber, Matthew R, Pettway, Glenda J, Rosol, Thomas J, Wronski, Thomas J, Kozloff, Ken M, McCauley, Laurie K

“…Proteoglycan 4 (Prg4), known for its lubricating and protective actions in joints, is a strong candidate regulator of skeletal homeostasis and parathyroid…”
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Impact of proteoglycan-4 and parathyroid hormone on articular cartilage by Novince, Chad M., Entezami, Payam, Wilson, Christopher G., Wang, Jason, Oh, Seo, Koh, Amy J., Michalski, Megan N., Sinder, Benjamin P., Kozloff, Kenneth M., Taichman, Russell S., McCauley, Laurie K.

“…Proteoglycan‐4 (Prg4) protects synovial joints from arthropathic changes by mechanisms that are incompletely understood. Parathyroid hormone (PTH), known for…”
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