Search Results - "Michalová, K."

Real-time quantitative PCR detection of WT1 gene expression in children with AML: prognostic significance, correlation with disease status and residual disease detection by flow cytometry by TRKA, J, KALINOVA, M, STARY, J, HRUSAK, O, ZUNA, J, KREJCI, O, MADZO, J, SEDLACEK, P, VAVRA, V, MICHALOVA, K, JAROSOVA, M

“…The clinical significance of WT1 gene expression at diagnosis and during therapy of AML has not yet been resolved. We analysed WT1 expression at presentation…”
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ESTABLISHED CELL LINES AND PATIENT‐DERIVED XENOGRAFTS REPRESENT EQUALLY RELEVANT MODELS OF AGGRESSIVE LYMPHOMAS by Klener, P., Klánová, M., Molinský, J., Svatoň, M., Berková, A., Zemanová, Z., Jakša, R., Špaček, M., Březinová, J., Tichá, I., Jančušková, T., Hardekopf, D.W., Forsterová, K., Froňková, E., Kotrová, M., Kubričanová‐Žaliová, M., Maswabi, B.C., Průková, D., Vočková, P., Tušková, D., Michalová, K., Trka, J., Trněný, M., Klener, P.

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Near-tetraploid acute myeloid leukemias: an EGIL retrospective study of 25 cases by Béné, M-C, Castoldi, G, Derolf, A, Garand, R, Haas, T, Haferlach, T, Knapp, W, Kuhlein, E, Lemez, P, Ludwig, W-D, Marinov, I, Matutes, E, Michalová, K, Porwit-MacDonald, A, Orfao, A, Schoch, C, Talmant, P, Van't Veer, M B, Zemanová, Z, Zühlsdorf, M

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Semiquantitative RT-PCR evaluation of the MDR1 gene expression in patients with acute myeloid leukemia by Trnková, Z, Bedrlíková, R, Marková, J, Michalová, K, Stöckbauer, P, Schwarz, J

“…Resistance to chemotherapy is one of the major obstacles to effective treatment in acute myeloid leukemia (AML). The most extensively studied protein involved…”
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The role of telomeres and telomerase complex in haematological neoplasia: the length of telomeres as a marker of carcinogenesis and prognosis of disease by Gancarcíková, M, Zemanová, Z, Brezinová, J, Berková, A, Vcelíková, S, Smigová, J, Michalová, K

“…Human telomeres (discovery of telomere structure and function has been recently awarded The Nobel Prize) consist of approximately 5-12 kb of tandem repeated…”
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O35 A prognostic impact of transfusion dependency on survival of patients with early myelodysplastic syndrome by Čermák, J, Kačírková, P, Mikulenková, D, Michalová, K

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Separation of replication and transcription domains in nucleoli by Smirnov, E., Borkovec, J., Kováčik, L., Svidenská, S., Schröfel, A., Skalníková, M., Švindrych, Z., Křížek, P., Ovesný, M., Hagen, G.M., Juda, P., Michalová, K., Cardoso, M.C., Cmarko, D., Raška, I.

“…In mammalian cells, active ribosomal genes produce the 18S, 5.8S and 28S RNAs of ribosomal particles. Transcription levels of these genes are very high…”
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Hereditary haemochromatosis caused by homozygous HJV mutation evolved through paternal disomy by Neřoldová, M., Fraňková, S., Stránecký, V., Honsová, E., Lukšan, O., Beneš, M., Michalová, K., Kmoch, S., Jirsa, M.

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Location of the BCR/ABL Fusion Genes on Both Chromosomes 9q34 in Ph Negative Chronic Myeloid Leukemia by Michalová, K., Zemanová, Z., B ezinová, J., Moravcová, J., Oltová, A., Sobotka, J., Kuglík, P., Kozák, T., šindelá ová, L., Jankovská, M., Obo ilová, A., Sieglová, Z., Polák, J., Nádvorníková, S., Haškovec, C.

“…We present two patients with Ph-negative chronic myeloid leukemia (CML) and fusion signal BCR/ABL on both chromosomes 9, located in region 9q34. The first case…”
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Smad5, a tumor suppressor candidate at 5q31.1, is hemizygously lost and not mutated in the retained allele in human leukemia cell line HL60 by ZAVADIL, J, BREZINOEVA, J, SVOBODA, P, ZEMANOVA, Z, MICHALOVA, K

“…Deletions of the long arm of chromosome 5 with common overlapping segment 5q31.1 are among the most frequent cytogenetic aberrations in myelodysplastic…”
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O51 Acute myeloid leukemia in the Czech Republic and the Slovak Republic from 1996 to 2007. Prognostic and therapeutic results of 1890 patients from the ALERT registry by Szotkowski, T, Voglová, J, Koza, V, Kozák, T, Doubek, M, Maaloufova, J, Kotouček, P, Demetrovičová, L, Tóthová, E, Chudej, L, Mayer, J, Žák, P, Cetkovský, P, Michalová, K, Jarošová, M, Demečková, E, Mužík, J, Dušek, L, Indrák, K

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MiR-155/miR-150 network regulates progression through the disease phases of chronic lymphocytic leukemia by Vargova, K, Pesta, M, Obrtlikova, P, Dusilkova, N, Minarik, L, Vargova, J, Berkova, A, Zemanova, Z, Michalova, K, Spacek, M, Trneny, M, Stopka, T

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Prognostic relevance of the FAB morphological criteria in chronic lymphocytic leukemia: correlations with IgVH gene mutational status and other prognostic markers by Schwarz, J, Mikulenková, D, Cermáková, M, Polanská, V, Michalová, K, Marinov, I, Campr, V, Ransdorfová, S, Marková, J, Pavlistová, L, Brezinová, J, Sajdová, J, Sponerová, D, Volková, Z, Benesová, K, Cermák, J, Vítek, A, Cetkovský, P

“…Morphological examination is the routine first step in the diagnosis of hematological malignancies, including chronic lymphocytic leukemia (CLL). Atypical cell…”
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High Level of Full-Length Cereblon Messenger RNA and Protein is Important for Lenalidomide Efficacy in Lower Risk MDS Patients by Fuchs, O, Polak, J, Bokorova, R, Kostecka, A, Vostry, M, Neuwirtova, R, Siskova, M, Stopka, T, Lauermannova, M, Maaloufova, J. Soukupova, Salek, C, Mikulenkova, D, Cermak, J, Brezinova, J, Zemanova, Z, Michalova, K, Jonasova, A

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Lenalidomide Treatment in Lower Risk MDS – The Experience of One Czech Center (Positive Effect of Erythropoietin ± Prednisone Addition) by Jonasova, A, Neuwirtova, R, Polackova, H, Siskova, M, Tomas, S, Cmunt, E, Belickova, M, Fuchs, O, Moudra, A, Michalova, K, Zemanova, Z

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Cytogenetic Clonal Evolution in Myelodysplastic Syndromes (MDS) with Isolated Del(5Q) by Zemanova, Z, Michalova, K, Brezinova, J, Svobodova, K, Lhotska, H, Sarova, I, Lizcova, L, Izakova, S, Ransdorfova, S, Pavlistova, L, Berkova, A, Skipalova, K, Belickova, M, Siskova, M, Neuwirtova, R, Cermak, J, Stopka, T, Jonasova, A

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MDS Patients with Del(5Q) and Trisomy 8 in Two Independent Clones Have High fli-1 and Cereblon Messenger RNA Levels by Fuchs, O, Polak, J, Bokorova, R, Kostecka, A, Vostry, M, Jonasova, A, Myslivcova, D, Siskova, M, Stopka, T, Lauermannova, M, Salek, C, Maaloufova, J. Soukupova, Mikulenkova, D, Cermak, J, Brezinova, J, Zemanova, Z, Michalova, K, Neuwirtova, R

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106 PATIENTS WITH TWO UNRELATED CLONES DEL(5Q) AND TRISOMY 8 – A SUBTYPE OF 5Q- SYNDOME? UNCERTAIN PROGNOSIS OF PATIENTS WITH DECREASED DEL(5Q) CLONE DUE TO LENALIDOMIDE by Neuwirtova, R, Zemanova, Z, Brezinova, J, Michalova, K, Dvorak, P, Oltova, A, Belickova, M, Fuchs, O, Cermak, J, Jonasova, A

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49 THE PROGNOSTIC SIGNIFICANCE OF TP53 MUTATIONS IN MDS PATIENTS WITH DEL(5Q) by Belickova, M, Vesela, J, Jonasova, A, Planetova, B, Valka, J, Mikulenkova, D, Zemanova, Z, Brezinova, J, Michalova, K, Cermak, J

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Disease status in patients with chronic myeloid leukemia is better characterized by BCR-ABL/BCR transcript ratio than by BCR-ABL transcript level, which may suggest a role of normal BCR gene in the disease pathogenesis by Moravcova, J, Regner, J, Mouckova, D, Fiser, K, Zmekova, V, Malacova, R, Michalova, K, Klamova, H

“…Monitoring of BCR-ABL transcript level is widely used in chronic myeloid leukemia (CML) to follow up response to therapy. In this study we compare abilities of…”
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