Search Results - "Michalkova, Radka"

Design, Synthesis and Antiproliferative Evaluation of Bis-Indole Derivatives with a Phenyl Linker: Focus on Autophagy by Marianna, Budovska, Radka, Michalkova, Martin, Kello, Janka, Vaskova, Jan, Mojzis

“…This work deals with the study of the synthesis of new bis-indole analogues with a phenyl linker derived from indole phytoalexins. Synthesis of target…”
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Chalcones and Gastrointestinal Cancers: Experimental Evidence by Michalkova, Radka, Kello, Martin, Cizmarikova, Martina, Bardelcikova, Annamaria, Mirossay, Ladislav, Mojzis, Jan

“…Colorectal (CRC) and gastric cancers (GC) are the most common digestive tract cancers with a high incidence rate worldwide. The current treatment including…”
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Anticancer Potential of Natural Chalcones: In Vitro and In Vivo Evidence by Michalkova, Radka, Mirossay, Ladislav, Kello, Martin, Mojzisova, Gabriela, Baloghova, Janette, Podracka, Anna, Mojzis, Jan

“…There is no doubt that significant progress has been made in tumor therapy in the past decades. However, the discovery of new molecules with potential…”
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Chalcone-Acridine Hybrid Suppresses Melanoma Cell Progression via G2/M Cell Cycle Arrest, DNA Damage, Apoptosis, and Modulation of MAP Kinases Activity by Gazdova, Maria, Michalkova, Radka, Kello, Martin, Vilkova, Maria, Kudlickova, Zuzana, Baloghova, Janette, Mirossay, Ladislav, Mojzis, Jan

“…This study was focused on investigating the antiproliferative effects of chalcone hybrids in melanoma cancer cells. Among seven chalcone hybrids, the…”
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Programmed Cell Death Alterations Mediated by Synthetic Indole Chalcone Resulted in Cell Cycle Arrest, DNA Damage, Apoptosis and Signaling Pathway Modulations in Breast Cancer Model by Michalkova, Radka, Kello, Martin, Kudlickova, Zuzana, Gazdova, Maria, Mirossay, Ladislav, Mojzisova, Gabriela, Mojzis, Jan

“…Although new chemotherapy significantly increased the survival of breast cancer (BC) patients, the use of these drugs is often associated with serious…”
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Antiproliferative Effect of Acridine Chalcone Is Mediated by Induction of Oxidative Stress by Takac, Peter, Kello, Martin, Vilkova, Maria, Vaskova, Janka, Michalkova, Radka, Mojzisova, Gabriela, Mojzis, Jan

“…Chalcones are naturally occurring phytochemicals with diverse biological activities including antioxidant, antiproliferative, and anticancer effects. Some…”
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Anticancer Potential of Indole Phytoalexins and Their Analogues by Zigová, Martina, Michalková, Radka, Mojžiš, Ján

“…Indole phytoalexins, found in economically significant family plants, are synthesized in response to pathogen attacks or stress, serving as crucial components…”
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Indole phytoalexins-derived bis-indoles: Design, synthesis and in vitro antiproliferative evaluation by Budovská, Mariana, Michalková, Radka, Mojžiš, Ján

“…Natural indole phytoalexins isolated from Brassicaceae plants have been identified as promising anticancer leads. Herein, we designed and synthesized six novel…”
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Aminoanalogues of isobrassinin, erucalexin and isocyclobrassinin: Synthesis and evaluation of the antiproliferative and cytotoxic properties by Budovská, Mariana, Krochtová, Kristína, Michalková, Radka, Mojžiš, Ján

“…This work deals with a synthetic effort to obtain regioisomeric amino analogues of the natural indole phytoalexins brassinin, 1-methoxyspirobrassinin and…”
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Spice-Derived Phenolic Compounds: Potential for Skin Cancer Prevention and Therapy by Baloghová, Janette, Michalková, Radka, Baranová, Zuzana, Mojžišová, Gabriela, Fedáková, Zuzana, Mojžiš, Ján

“…Skin cancer is a condition characterized by the abnormal growth of skin cells, primarily caused by exposure to ultraviolet (UV) radiation from the sun or…”
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Exploring the Antiproliferative and Modulatory Effects of 1-Methoxyisobrassinin on Ovarian Cancer Cells: Insights into Cell Cycle Regulation, Apoptosis, Autophagy, and Its Interactions with NAC by Zigová, Martina, Miškufová, Viktória, Budovská, Marianna, Michalková, Radka, Mojžiš, Ján

“…Ovarian cancer, a highly lethal malignancy among reproductive organ cancers, poses a significant challenge with its high mortality rate, particularly in…”
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The Induction of G2/M Phase Cell Cycle Arrest and Apoptosis by the Chalcone Derivative 1C in Sensitive and Resistant Ovarian Cancer Cells Is Associated with ROS Generation by Salanci, Šimon, Vilková, Mária, Martinez, Lola, Mirossay, Ladislav, Michalková, Radka, Mojžiš, Ján

“…Ovarian cancer ranks among the most severe forms of cancer affecting the female reproductive organs, posing a significant clinical challenge primarily due to…”
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Design, Synthesis, and Evaluation of Novel Indole Hybrid Chalcones and Their Antiproliferative and Antioxidant Activity by Kudličková, Zuzana, Michalková, Radka, Salayová, Aneta, Ksiažek, Marián, Vilková, Mária, Bekešová, Slávka, Mojžiš, Ján

“…The synthesis, anticancer, and antioxidant activities of a series of indole-derived hybrid chalcones are reported here. First, using the well-known…”
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The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future? by Takáč, Peter, Michalková, Radka, Čižmáriková, Martina, Bedlovičová, Zdenka, Balážová, Ľudmila, Takáčová, Gabriela

“…Cancer is a fatal disease with a complex pathophysiology. Lack of specificity and cytotoxicity, as well as the multidrug resistance of traditional cancer…”
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Design, Synthesis, and Characterization of Novel Thiazolidine-2,4-Dione-Acridine Hybrids as Antitumor Agents by Garberová, Monika, Kudličková, Zuzana, Michalková, Radka, Tvrdoňová, Monika, Sabolová, Danica, Bekešová, Slávka, Gramblička, Michal, Mojžiš, Ján, Vilková, Mária

“…This study focuses on the synthesis and structural characterization of new compounds that integrate thiazolidine-2,4-dione, acridine moiety, and an acetamide…”
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Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence by Čižmáriková, Martina, Michalková, Radka, Mirossay, Ladislav, Mojžišová, Gabriela, Zigová, Martina, Bardelčíková, Annamária, Mojžiš, Ján

“…Cancer is a complex and multifaceted disease with a high global incidence and mortality rate. Although cancer therapy has evolved significantly over the years,…”
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Discovery of novel acridine-chalcone hybrids with potent DNA binding and antiproliferative activity against MDA-MB-231 and MCF-7 cells by Vilková, Mária, Michalková, Radka, Kello, Martin, Sabolová, Danica, Takáč, Peter, Kudličková, Zuzana, Garberová, Monika, Tvrdoňová, Monika, Béres, Tibor, Mojžiš, Ján

“…Two series of novel chalcone derivatives containing acridin-9-yl or acridin-4-yl moiety have been synthesized, structure elucidated and further evaluated for…”
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Design, synthesis, and biological evaluation of novel 5-bromo derivatives of indole phytoalexins by Budovská, Mariana, Selešová, Ivana, Tischlerová, Viera, Michalková, Radka, Mojžiš, Ján

“…The increasing diversity of small molecule libraries is a major source for the discovery of new drug candidates. In terms of this trend, we report the…”
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Mechanochemical synthesis of indolyl chalcones with antiproliferative activity by Kudličková, Zuzana, Stahorský, Martin, Michalková, Radka, Vilková, Mária, Baláž, Matej

“…An efficient eco-friendly one-step mechanochemical synthesis of indole hybrid chalcones via the Claisen-Schmidt condensation of 1-methylindole-3-carboxaldehyde…”
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Molecular Mechanisms of Antiproliferative Effects of Natural Chalcones by Michalkova, Radka, Mirossay, Ladislav, Gazdova, Maria, Kello, Martin, Mojzis, Jan

“…Although great progress has been made in the treatment of cancer, the search for new promising molecules with antitumor activity is still one of the greatest…”
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