Search Results - "Michalak, Tomasz I."

The Initial Hepatitis B Virus-Hepatocyte Genomic Integrations and Their Role in Hepatocellular Oncogenesis by Michalak, Tomasz I

“…Hepatitis B virus (HBV) remains a dominant cause of hepatocellular carcinoma (HCC). Recently, it was shown that HBV and woodchuck hepatitis virus (WHV)…”
Get full text

Diverse Virus and Host-Dependent Mechanisms Influence the Systemic and Intrahepatic Immune Responses in the Woodchuck Model of Hepatitis B by Michalak, Tomasz I

“…Woodchuck infected with woodchuck hepatitis virus (WHV) represents the pathogenically nearest model of hepatitis B and associated hepatocellular carcinoma…”
Get full text

Hepadnaviral Lymphotropism and Its Relevance to HBV Persistence and Pathogenesis by Coffin, Carla S., Mulrooney-Cousins, Patricia M., Michalak, Tomasz I.

“…Since the discovery of hepatitis B virus (HBV) over five decades ago, there have been many independent studies showing presence of HBV genomes in cells of the…”
Get full text

Differential Expression of Woodchuck Toll-Like Receptors 1-10 in Distinct Forms of Infection and Stages of Hepatitis in Experimental Hepatitis B Virus Infection by Williams, John Bradley, Hüppner, Alena, Mulrooney-Cousins, Patricia M, Michalak, Tomasz I

“…Woodchucks infected with woodchuck hepatitis virus (WHV) represent a highly valuable model of human hepatitis B virus (HBV) infection, chronic hepatitis (CH),…”
Get full text

Identification of antibodies cross-reactive with woodchuck immune cells and activation of virus-specific and global cytotoxic T cell responses by anti-PD-1 and anti-PD-L1 in experimental chronic hepatitis B and persistent occult hepadnaviral infection by Corkum, Christopher P, Wiede, Louisa L, Ruble, Cara L-A, Qiu, Jiabin, Mulrooney-Cousins, Patricia M, Steeves, Meredith A, Watson, David E, Michalak, Tomasz I

“…Woodchuck infected with woodchuck hepatitis virus (WHV) is the most pathogenically compatible naturally occurring model of human hepatitis B virus (HBV)…”
Get full text

Primary seronegative but molecularly evident hepadnaviral infection engages liver and induces hepatocarcinoma in the woodchuck model of hepatitis B by Mulrooney-Cousins, Patricia M, Chauhan, Ranjit, Churchill, Norma D, Michalak, Tomasz I

“…Hepadnavirus at very low doses establishes in woodchucks asymptomatic, serologically undetectable but molecularly evident persistent infection. This primary…”
Get full text

Persistent occult hepatitis B virus infection： Experimental findings and clinical implications by Patricia M Mulrooney-Cousins Tomasz I Michalak

“…Hepatitis B virus （HBV） is a highly pathogenic virus that causes chronic liver diseases in millions of people globally. In addition to a symptomatic,…”
Get full text

Reactivation of hepatitis B after liver transplantation: Current knowledge, molecular mechanisms and implications in management by Chauhan, Ranjit, Lingala, Shilpa, Gadiparthi, Chiranjeevi, Lahiri, Nivedita, Mohanty, Smruti R, Wu, Jian, Michalak, Tomasz I, Satapathy, Sanjaya K

“…Chronic hepatitis B (CHB) is a major global health problem affecting an estimated 350 million people with more than 786000 individuals dying annually due to…”
Get full text

Hepatitis C Virus Infection of Human T Lymphocytes Is Mediated by CD5 by SARHAN, Mohammed A, PHAM, Tram N. Q, CHEN, Annie Y, MICHALAK, Tomasz I

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Hepatitis C Virus Replicates in the Same Immune Cell Subsets in Chronic Hepatitis C and Occult Infection by Pham, Tram N.Q, King, Dawn, MacParland, Sonya A, McGrath, Jerry S, Reddy, S. Bharati, Bursey, Ford R, Michalak, Tomasz I

“…Background & Aims: Infection of the lymphatic system by hepatitis C virus (HCV) appears to be an intrinsic characteristic of chronic hepatitis C (CHC) and…”
Get full text

Hepatitis C Virus Persistence after Spontaneous or Treatment-Induced Resolution of Hepatitis C by PHAM, Tram N. Q, MACPARLAND, Sonya A, MULROONEY, Patricia M, COOKSLEY, Helen, NAOUMOV, Nikolai V, MICHALAK, Tomasz I

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Intrahepatic Expression of Genes Affiliated with Innate and Adaptive Immune Responses Immediately after Invasion and during Acute Infection with Woodchuck Hepadnavirus by GUY, Clifford S, MULROONEY-COUSINS, Patricia M, CHURCHILL, Norma D, MICHALAK, Tomasz I

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Persistence of Hepatitis C Virus Traces after Spontaneous Resolution of Hepatitis C by Chen, Annie Y, Hoare, Matthew, Shankar, Arun N, Allison, Michael, Alexander, Graeme J M, Michalak, Tomasz I

“…Hepatitis C virus (HCV) frequently causes chronic hepatitis, while spontaneous recovery from infection is infrequent. Persistence of HCV after self-limited…”
Get full text

Hepatitis C virus persisting after clinically apparent sustained virological response to antiviral therapy retains infectivity in vitro by MacParland, Sonya A., Pham, Tram N. Q., Guy, Clifford S., Michalak, Tomasz I.

“…Hepatitis C virus (HCV) can persist in the liver, lymphoid cells, and serum of individuals with apparently complete spontaneous or therapy‐induced resolution…”
Get full text

Differential expression of candidate virus receptors in human T lymphocytes prone or resistant to infection with patient-derived hepatitis C virus by Sarhan, Mohammed A, Chen, Annie Y, Michalak, Tomasz I

“…Accumulated evidence implies that hepatitis C virus (HCV) infects not only the liver but also the immune system. A lymphocyte-specific CD5 molecule was…”
Get full text

Hepatocyte cytotoxicity is facilitated by asialoglycoprotein receptor by Guy, Clifford S., Rankin, Sherri L., Michalak, Tomasz I.

“…It has been recently identified that hepatocytes can act as cytotoxic effectors and can kill contacted cells by way of CD95 ligand–CD95 and perforin‐dependent…”
Get full text

Repeated Exposure to Trace Amounts of Woodchuck Hepadnavirus Induces Molecularly Evident Infection and Virus-Specific T Cell Response in the Absence of Serological Infection Markers and Hepatitis by Gujar, Shashi A, Mulrooney-Cousins, Patricia M, Michalak, Tomasz I

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Persistence of hepatitis C virus during and after otherwise clinically successful treatment of chronic hepatitis C with standard pegylated interferon α-2b and ribavirin therapy by Chen, Annie Y, Zeremski, Marija, Chauhan, Ranjit, Jacobson, Ira M, Talal, Andrew H, Michalak, Tomasz I

“…Resolution of chronic hepatitis C is considered when serum HCV RNA becomes repeatedly undetectable and liver enzymes normalize. However, long-term persistence…”
Get full text

Primary Occult Hepadnavirus Infection Induces Virus-Specific T-Cell and Aberrant Cytokine Responses in the Absence of Antiviral Antibody Reactivity in the Woodchuck Model of Hepatitis B Virus Infection by GUJAR, Shashi A, MICHALAK, Tomasz I

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Occult persistence and lymphotropism of hepatitis C virus infection by Pham, Tram-Nq, Michalak, Tomasz-I

“…Recent discovery of occult hepatitis C virus (HCV) infection persisting after spontaneous or antiviral therapy-induced resolution of hepatitis C was made…”
Get full text