Search Results - "Michalak, Sharon E."

Site-Selective Aliphatic C–H Chlorination Using N‑Chloroamides Enables a Synthesis of Chlorolissoclimide by Quinn, Ryan K, Könst, Zef A, Michalak, Sharon E, Schmidt, Yvonne, Szklarski, Anne R, Flores, Alex R, Nam, Sangkil, Horne, David A, Vanderwal, Christopher D, Alexanian, Erik J

“…Methods for the practical, intermolecular functionalization of aliphatic C–H bonds remain a paramount goal of organic synthesis. Free radical alkane…”
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Dopaminergic Control of Striatal Cholinergic Interneurons Underlies Cocaine-Induced Psychostimulation by Lewis, Robert G., Serra, Marcello, Radl, Daniela, Gori, Michela, Tran, Catherine, Michalak, Sharon E., Vanderwal, Christopher D., Borrelli, Emiliana

“…Cocaine drastically elevates dopamine (DA) levels in the striatum, a brain region that is critical to the psychomotor and rewarding properties of the drug. DA…”
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Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides by Könst, Zef A., Szklarski, Anne R., Pellegrino, Simone, Michalak, Sharon E., Meyer, Mélanie, Zanette, Camila, Cencic, Regina, Nam, Sangkil, Voora, Vamsee K., Horne, David A., Pelletier, Jerry, Mobley, David L., Yusupova, Gulnara, Yusupov, Marat, Vanderwal, Christopher D.

“…The lissoclimides are unusual succinimide-containing labdane diterpenoids that were reported to be potent cytotoxins. Our short semisynthesis and…”
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A Chlorine-Atom-Controlled Terminal-Epoxide-Initiated Bicyclization Cascade Enables a Synthesis of the Potent Cytotoxins Haterumaimides J and K by Michalak, Sharon E, Nam, Sangkil, Kwon, David M, Horne, David A, Vanderwal, Christopher D

“…Haterumaimide J (hatJ) is reportedly the most cytotoxic member of the lissoclimide family of labdane diterpenoids. The unusual functional group arrangement of…”
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Green Chemistry as a Driver for Innovation in the Pharmaceutical Industry by Beaver, Matthew G., Caille, Seb, Içten, Elçin, Michalak, Sharon E., St‐Pierre, Gabrielle, Thiel, Oliver R.

“…The application of green chemistry principles is foundational in the route section and route development for active pharmaceutical ingredients at Amgen. In…”
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