Search Results - "Michailova, Anushka P"

Calcium and IP3 dynamics in cardiac myocytes: experimental and computational perspectives and approaches by Hohendanner, Felix, McCulloch, Andrew D, Blatter, Lothar A, Michailova, Anushka P

“…Calcium plays a crucial role in excitation-contraction coupling (ECC), but it is also a pivotal second messenger activating Ca(2+)-dependent transcription…”
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Molecular and Subcellular-Scale Modeling of Nucleotide Diffusion in the Cardiac Myofilament Lattice by Kekenes-Huskey, Peter M., Liao, Tao, Gillette, Andrew K., Hake, Johan E., Zhang, Yongjie, Michailova, Anushka P., McCulloch, Andrew D., McCammon, J. Andrew

“…Contractile function of cardiac cells is driven by the sliding displacement of myofilaments powered by the cycling myosin crossbridges. Critical to this…”
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Numerical analysis of Ca2+ signaling in rat ventricular myocytes with realistic transverse-axial tubular geometry and inhibited sarcoplasmic reticulum by Cheng, Yuhui, Yu, Zeyun, Hoshijima, Masahiko, Holst, Michael J, McCulloch, Andrew D, McCammon, J Andrew, Michailova, Anushka P

“…The t-tubules of mammalian ventricular myocytes are invaginations of the cell membrane that occur at each Z-line. These invaginations branch within the cell to…”
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Modelling cardiac calcium sparks in a three‐dimensional reconstruction of a calcium release unit by Hake, Johan, Edwards, Andrew G., Yu, Zeyun, Kekenes‐Huskey, Peter M., Michailova, Anushka P., McCammon, J. Andrew, Holst, Michael J., Hoshijima, Masahiko, McCulloch, Andrew D.

“…Key points •  We have developed a detailed computational model of a cardiac Ca2+ spark based on a three dimensional reconstruction of electron tomograms. • …”
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Modeling beta-adrenergic control of cardiac myocyte contractility in silico by Saucerman, Jeffrey J., Brunton, Laurence L., Michailova, Anushka P., McCulloch, Andrew D., McCullough, A. D.

“…The beta-adrenergic signaling pathway regulates cardiac myocyte contractility through a combination of feedforward and feedback mechanisms. We used systems…”
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Modeling Calcium Sparks in a Three-Dimensional Reconstruction of a Cardiac Calcium Release Unit by Hake, Johan E., Edwards, Andrew G., Yu, Zeyun, Kekenes-Huskey, Peter, Michailova, Anushka P., McCammon, Andrew J., Holst, Michael J., Hoshijima, Masahiko, McCulloch, Andrew D.

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Effects of Magnesium on Cardiac Excitation-Contraction Coupling by Michailova, Anushka P, Belik, Mary Ellen, McCulloch, Andrew D

“…Objective: Magnesium regulates a large number of cellular processes. Small changes in intracellular free Mg 2+ ([Mg 2+ ] i ) may have important effects on…”
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Numerical analysis of [CA.sup.2+] signaling in rat ventricular myocytes with realistic transverse-axial tubular geometry and inhibited sarcoplasmic reticulum by Cheng, Yuhui, Yu, Zeyun, Hoshijima, Masahiko, Holst, Michael J, McCulloch, Andrew D, McCammon, J. Andrew, Michailova, Anushka P

“…The t-tubules of mammalian ventricular myocytes are invaginations of the cell membrane that occur at each Z-line. These invaginations branch within the cell to…”
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Numerical Analysis of Ca2+ Signaling in Rat Ventricular Myocytes with Realistic Transverse-Axial Tubular Geometry and Inhibited Sarcoplasmic Reticulum: e1000972 by Cheng, Yuhui, Yu, Zeyun, Hoshijima, Masahiko, Holst, Michael J, McCulloch, Andrew D, McCammon, J Andrew, Michailova, Anushka P

“…The t-tubules of mammalian ventricular myocytes are invaginations of the cell membrane that occur at each Z-line. These invaginations branch within the cell to…”
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Modeling Effects of L-Type Ca2+ Current and Na+-Ca2+ Exchanger on Ca2+ Trigger Flux in Rabbit Myocytes with Realistic T-Tubule Geometries by Kekenes-Huskey, Peter M., Cheng, Yuhui, Hake, Johan E., Sachse, Frank B., Bridge, John H., Holst, Michael J., McCammon, J. Andrew, McCulloch, Andrew D., Michailova, Anushka P.

“…The transverse tubular system of rabbit ventricular myocytes consists of cell membrane invaginations (t-tubules) that are essential for efficient cardiac…”
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Modeling effects of L-type ca(2+) current and na(+)-ca(2+) exchanger on ca(2+) trigger flux in rabbit myocytes with realistic T-tubule geometries by Kekenes-Huskey, Peter M, Cheng, Yuhui, Hake, Johan E, Sachse, Frank B, Bridge, John H, Holst, Michael J, McCammon, J Andrew, McCulloch, Andrew D, Michailova, Anushka P

“…The transverse tubular system of rabbit ventricular myocytes consists of cell membrane invaginations (t-tubules) that are essential for efficient cardiac…”
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Modeling β-Adrenergic Control of Cardiac Myocyte Contractility in Silico by Jeffrey J. Saucerman, Laurence L. Brunton, Anushka P. Michailova, Andrew D. McCulloch

“…The β-adrenergic signaling pathway regulates cardiac myocyte contractility through a combination of feedforward and feedback mechanisms. We used systems…”
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Theoretical model and computer simulation of excitation-contraction coupling of mammalian cardiac muscle by Michailova, A P, Spassov, V Z

“…A mathematical model is developed to investigate the kinetics of electrical, mechanical and molecular processes in mammalian cardiac muscle. Isometric…”
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Multiscale modeling in rodent ventricular myocytes by Shaoying Lu, Michailova, A., Saucerman, J., Yuhui Cheng, Zeyun Yu, Kaiser, T., Li, W., Bank, R., Holst, M., Mccammon, J., Hayashi, T., Hoshijima, M., Arzberger, P., McCulloch, A.

“…This paper indicates that in ventricular myocytes when the SR (sarcoplasmic reticulum) is pharmacologically inhibited, the intracellular Ca 2+ concentration…”
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