Search Results - "Michailidou, Freideriki"

Synthesis and Conformational Analysis of Fluorinated Uridine Analogues Provide Insight into a Neighbouring-Group Participation Mechanism by Michailidou, Freideriki, Lebl, Tomas, Slawin, Alexandra M Z, Sharma, Sunil Vishnuprasadji, Brown, Murray J B, Goss, Rebecca Jane Miriam

“…Fluorinated nucleoside analogues have attracted much attention as anticancer and antiviral agents and as probes for enzymatic function. However, the lack of…”
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Engineering of Therapeutic and Detoxifying Enzymes by Michailidou, Freideriki

“…Therapeutic enzymes present excellent opportunities for the treatment of human disease, modulation of metabolic pathways and system detoxification. However,…”
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The Scent of Change: Sustainable Fragrances Through Industrial Biotechnology by Michailidou, Freideriki

“…Abstract Current environmental and safety considerations urge innovation to address the need for sustainable high‐value chemicals that are embraced by…”
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Harnessing methylation and AdoMet-utilising enzymes for selective modification in cascade reactions by Michailidou, Freideriki, Rentmeister, Andrea

“…Enzyme-mediated methylation is a very important reaction in nature, yielding a wide range of modified natural products, diversifying small molecules and…”
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Engineering of Therapeutic and Detoxifying Enzymes by Michailidou, Freideriki

“…Therapeutic enzymes present excellent opportunities for the treatment of human disease, modulation of metabolic pathways and system detoxification. However,…”
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Hair Dye Ingredients and Potential Health Risks from Exposure to Hair Dyeing by He, Lin, Michailidou, Freideriki, Gahlon, Hailey L., Zeng, Weibin

“…Given the worldwide popularity of hair dyeing, there is an urgent need to understand the toxicities and risks associated with exposure to chemicals found in…”
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Scent and sustainability: investigating consumer evaluations of biocatalysis and naturalness in fragrances by Michailidou, Freideriki, Bearth, Angela, Deilmann, Constantin, Siegrist, Michael

“…•Biotechnology-based fragrances could improve the sustainability of fragrances.•Study extents insights from prior study on naturalness and fragrances.•Does not…”
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Nucleoside-modified AdoMet analogues for differential methyltransferase targeting by Cornelissen, Nicolas V, Michailidou, Freideriki, Muttach, Fabian, Rau, Kristina, Rentmeister, Andrea

“…Methyltransferases (MTases) modify a wide range of biomolecules using S-adenosyl-l-methionine (AdoMet) as the cosubstrate. Synthetic AdoMet analogues are…”
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Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogs with Photocaging Groups and Reversible DNA Modification in Cascade Reactions by Michailidou, Freideriki, Klöcker, Nils, Cornelissen, Nicolas V., Singh, Rohit K., Peters, Aileen, Ovcharenko, Anna, Kümmel, Daniel, Rentmeister, Andrea

“…Methylation and demethylation of DNA, RNA and proteins has emerged as a major regulatory mechanism. Studying the function of these modifications would benefit…”
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Cover Picture: Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogs with Photocaging Groups and Reversible DNA Modification in Cascade Reactions (Angew. Chem. Int. Ed. 1/2021) by Michailidou, Freideriki, Klöcker, Nils, Cornelissen, Nicolas V., Singh, Rohit K., Peters, Aileen, Ovcharenko, Anna, Kümmel, Daniel, Rentmeister, Andrea

“…Sequence‐specific modification (“writing”) and light‐triggered removal (“erasing”) of DNA is reported for the first time in an enzymatic cascade. In their…”
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Structural and mechanistic studies on the biosynthesis of the 3'-deoxy nucleoside of the pacidamycins by Michailidou, Freideriki

“…Nucleic acids are ubiquitous in nature and modified nucleosides are present in a wide range of anti-viral, anti-cancer drugs and antibiotics. Although a…”
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Corrigendum: Pac13 is a Small Dehydratase that Mediates the Formation of the 3′‐Deoxy Nucleoside of Pacidamycins by Michailidou, Freideriki, Chung, Chun‐wa, Brown, Murray J. B., Naismith, James H., Leavens, William J., Lynn, Sean M., Sharma, Sunil V., Goss, Rebecca J. M.

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Pac13 is a Small, Monomeric Dehydratase that Mediates the Formation of the 3′‐Deoxy Nucleoside of Pacidamycins by Michailidou, Freideriki, Chung, Chun‐wa, Brown, Murray J. B., Bent, Andrew F., Naismith, James H., Leavens, William J., Lynn, Sean M., Sharma, Sunil V., Goss, Rebecca J. M.

“…The uridyl peptide antibiotics (UPAs), of which pacidamycin is a member, have a clinically unexploited mode of action and an unusual assembly. Perhaps the most…”
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Maßgeschneiderte SAM‐Synthetasen zur enzymatischen Herstellung von AdoMet‐Analoga mit Photoschutzgruppen und zur reversiblen DNA‐Modifizierung in Kaskadenreaktionen by Michailidou, Freideriki, Klöcker, Nils, Cornelissen, Nicolas V., Singh, Rohit K., Peters, Aileen, Ovcharenko, Anna, Kümmel, Daniel, Rentmeister, Andrea

“…Die Methylierung und Demethylierung von DNA, RNA und Proteinen stellt einen wichtigen Regulationsmechanismus dar. Um die Funktionen dieser Modifikationen…”
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Berichtigung: Pac13 is a Small Dehydratase that Mediates the Formation of the 3′‐Deoxy Nucleoside of Pacidamycins by Michailidou, Freideriki, Chung, Chun‐wa, Brown, Murray J. B., Naismith, James H., Leavens, William J., Lynn, Sean M., Sharma, Sunil V., Goss, Rebecca J. M.

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Maßgeschneiderte SAM‐Synthetasen zur enzymatischen Herstellung von AdoMet‐Analoga mit Photoschutzgruppen und zur reversiblen DNA‐Modifizierung in Kaskadenreaktionen by Michailidou, Freideriki, Klöcker, Nils, Cornelissen, Nicolas V., Singh, Rohit K., Peters, Aileen, Ovcharenko, Anna, Kümmel, Daniel, Rentmeister, Andrea

“…Abstract Die Methylierung und Demethylierung von DNA, RNA und Proteinen stellt einen wichtigen Regulationsmechanismus dar. Um die Funktionen dieser…”
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Titelbild: Maßgeschneiderte SAM‐Synthetasen zur enzymatischen Herstellung von AdoMet‐Analoga mit Photoschutzgruppen und zur reversiblen DNA‐Modifizierung in Kaskadenreaktionen (Angew. Chem. 1/2021) by Michailidou, Freideriki, Klöcker, Nils, Cornelissen, Nicolas V., Singh, Rohit K., Peters, Aileen, Ovcharenko, Anna, Kümmel, Daniel, Rentmeister, Andrea

“…Die sequenzspezifische Modifikation (“Schreiben”) und lichtinduzierte Entfernung (“Löschen”) von DNA wird erstmals in einer enzymatischen Kaskade beschrieben…”
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Pac13 is a Small, Monomeric Dehydratase that Mediates the Formation of the 3′‐Deoxy Nucleoside of Pacidamycins by Michailidou, Freideriki, Chung, Chun‐wa, Brown, Murray J. B., Bent, Andrew F., Naismith, James H., Leavens, William J., Lynn, Sean M., Sharma, Sunil V., Goss, Rebecca J. M.

“…The uridyl peptide antibiotics (UPAs), of which pacidamycin is a member, have a clinically unexploited mode of action and an unusual assembly. Perhaps the most…”
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