Search Results - "Michaelsen, Signe"

Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor by Christensen, Camilla L., Kwiatkowski, Nicholas, Abraham, Brian J., Carretero, Julian, Al-Shahrour, Fatima, Zhang, Tinghu, Chipumuro, Edmond, Herter-Sprie, Grit S., Akbay, Esra A., Altabef, Abigail, Zhang, Jianming, Shimamura, Takeshi, Capelletti, Marzia, Reibel, Jakob B., Cavanaugh, Jillian D., Gao, Peng, Liu, Yan, Michaelsen, Signe R., Poulsen, Hans S., Aref, Amir R., Barbie, David A., Bradner, James E., George, Rani E., Gray, Nathanael S., Young, Richard A., Wong, Kwok-Kin

“…Small cell lung cancer (SCLC) is an aggressive disease with high mortality, and the identification of effective pharmacological strategies to target SCLC…”
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VEGF-C sustains VEGFR2 activation under bevacizumab therapy and promotes glioblastoma maintenance by Michaelsen, Signe R, Staberg, Mikkel, Pedersen, Henriette, Jensen, Kamilla E, Majewski, Wiktor, Broholm, Helle, Nedergaard, Mette K, Meulengracht, Christopher, Urup, Thomas, Villingshøj, Mette, Lukacova, Slávka, Skjøth-Rasmussen, Jane, Brennum, Jannick, Kjær, Andreas, Lassen, Ulrik, Stockhausen, Marie-Thérése, Poulsen, Hans S, Hamerlik, Petra

“…Glioblastoma ranks among the most lethal cancers, with current therapies offering only palliation. Paracrine vascular endothelial growth factor (VEGF)…”
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GDNF/GFRA1 signaling contributes to chemo- and radioresistance in glioblastoma by Avenel, Inès C. N., Ewald, Jesper D., Ariey-Bonnet, Jérémy, Kristensen, Ida H., Petterson, Stine A., Thesbjerg, Martin N., Burton, Mark, Thomassen, Mads, Wennerberg, Krister, Michaelsen, Signe R., Kristensen, Bjarne W.

“…Glioblastoma is the most common primary brain tumor in adults, characterized by an inherent aggressivity and resistance to treatment leading to poor prognoses…”
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Clinical Characteristics of Gliosarcoma and Outcomes From Standardized Treatment Relative to Conventional Glioblastoma by Frandsen, Simone, Broholm, Helle, Larsen, Vibeke Andrée, Grunnet, Kirsten, Møller, Søren, Poulsen, Hans Skovgaard, Michaelsen, Signe Regner

“…Gliosarcoma (GS) is a rare histopathologic variant of glioblastoma (GBM) characterized by a biphasic growth pattern consisting of both glial and sarcomatous…”
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Clinical variables serve as prognostic factors in a model for survival from glioblastoma multiforme: an observational study of a cohort of consecutive non-selected patients from a single institution by Michaelsen, Signe Regner, Christensen, Ib Jarle, Grunnet, Kirsten, Stockhausen, Marie-Thérése, Broholm, Helle, Kosteljanetz, Michael, Poulsen, Hans Skovgaard

“…Although implementation of temozolomide (TMZ) as a part of primary therapy for glioblastoma multiforme (GBM) has resulted in improved patient survival, the…”
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VEGF-C as a putative therapeutic target in cancer by Michaelsen, Signe R, Poulsen, Hans S, Hamerlik, Petra

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Loss of cancer cell‐derived ADAM15 alters the tumor microenvironment in colorectal tumors by Puig‐Blasco, Laia, Piotrowski, Krzysztof B., Michaelsen, Signe R., Bager, Nicolai S., Areškevičiūtė, Aušrinė, Thorseth, Marie‐Louise, Sun, Xiao‐Feng, Keller, Ulrich auf dem, Kristensen, Bjarne W., Madsen, Daniel H., Gnosa, Sebastian P., Kveiborg, Marie

“…Abstract Tumor progression and response to treatment are highly affected by interactions between cancer cells and the tumor microenvironment (TME). Many of the…”
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Assessment of Quantitative and Allelic MGMT Methylation Patterns as a Prognostic Marker in Glioblastoma by Kristensen, Lasse S., Michaelsen, Signe R., Dyrbye, Henrik, Aslan, Derya, Grunnet, Kirsten, Christensen, Ib J., Poulsen, Hans S., Grønbæk, Kirsten, Broholm, Helle

“…Methylation of the O6-methylguanine-DNA methyltransferase (MGMT) gene is a predictive and prognostic marker in newly diagnosed glioblastoma patients treated…”
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Genomic profiling of newly diagnosed glioblastoma patients and its potential for clinical utility – a prospective, translational study by Nørøxe, Dorte S., Yde, Christina W., Østrup, Olga, Michaelsen, Signe R., Schmidt, Ane Y., Kinalis, Savvas, Torp, Mathias H., Skjøth‐Rasmussen, Jane, Brennum, Jannick, Hamerlik, Petra, Poulsen, Hans S., Nielsen, Finn C., Lassen, Ulrik

“…Landscape of somatic copy number alterations, mutations, and fusions in selected genes in newly diagnosed glioblastoma patients. The most frequent aberrations…”
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DNA Methylation Levels of the ELMO Gene Promoter CpG Islands in Human Glioblastomas by Michaelsen, Signe Regner, Aslan, Derya, Urup, Thomas, Poulsen, Hans Skovgaard, Grønbæk, Kirsten, Broholm, Helle, Kristensen, Lasse Sommer

“…Complete surgical resection of glioblastoma is difficult due to the invasive nature of this primary brain tumor, for which the molecular mechanisms behind…”
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Urokinase-Type Plasminogen Activator Receptor as a Potential PET Biomarker in Glioblastoma by Persson, Morten, Nedergaard, Mette K, Brandt-Larsen, Malene, Skovgaard, Dorthe, Jørgensen, Jesper T, Michaelsen, Signe R, Madsen, Jacob, Lassen, Ulrik, Poulsen, Hans S, Kjaer, Andreas

“…Glioblastoma is one of the most malignant types of human cancer, and the prognosis is poor. The development and validation of novel molecular imaging…”
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The use of longitudinal 18F-FET MicroPET imaging to evaluate response to irinotecan in orthotopic human glioblastoma multiforme xenografts by Nedergaard, Mette K, Kristoffersen, Karina, Michaelsen, Signe R, Madsen, Jacob, Poulsen, Hans S, Stockhausen, Marie-Thérése, Lassen, Ulrik, Kjaer, Andreas

“…Brain tumor imaging is challenging. Although 18F-FET PET is widely used in the clinic, the value of 18F-FET MicroPET to evaluate brain tumors in xenograft has…”
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Extracranial metastases in glioblastoma—Two case stories by Schou Nørøxe, Dorte, Regner Michaelsen, Signe, Broholm, Helle, Møller, Søren, Skovgaard Poulsen, Hans, Lassen, Ulrik

“…Key Clinical Message The clinician should always consider extracranial metastases in glioblastoma. Increased risk factors are young age at diagnosis, histology…”
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Glioblastoma cells increase expression of notch signaling and synaptic genes within infiltrated brain tissue by Harwood, Dylan Scott Lykke, Pedersen, Vilde, Bager, Nicolai Schou, Schmidt, Ane Yde, Stannius, Tobias Overlund, Areškevičiūtė, Aušrinė, Josefsen, Knud, Nørøxe, Dorte Schou, Scheie, David, Rostalski, Hannah, Lü, Maya Jeje Schuang, Locallo, Alessio, Lassen, Ulrik, Bagger, Frederik Otzen, Weischenfeldt, Joachim, Heiland, Dieter Henrik, Vitting-Seerup, Kristoffer, Michaelsen, Signe Regner, Kristensen, Bjarne Winther

“…Glioblastoma remains one of the deadliest brain malignancies. First-line therapy consists of maximal surgical tumor resection, accompanied by chemotherapy and…”
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Molecular profiling of short-term and long-term surviving patients identifies CD34 mRNA level as prognostic for glioblastoma survival by Michaelsen, Signe Regner, Urup, Thomas, Olsen, Lars Rønn, Broholm, Helle, Lassen, Ulrik, Poulsen, Hans Skovgaard

“…Despite extensive treatment, overall survival (OS) for glioblastoma (GBM) remains poor. A small proportion of patients present long survival over 3 years, but…”
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The impact of bevacizumab treatment on survival and quality of life in newly diagnosed glioblastoma patients by Poulsen, Hans Skovgaard, Urup, Thomas, Michaelsen, Signe Regner, Staberg, Mikkel, Villingshøj, Mette, Lassen, Ulrik

“…Glioblastoma multiforme (GBM) remains one of the most devastating tumors, and patients have a median survival of 15 months despite aggressive local and…”
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Targeting glioma stem‐like cell survival and chemoresistance through inhibition of lysine‐specific histone demethylase KDM2B by Staberg, Mikkel, Rasmussen, Rikke Darling, Michaelsen, Signe Regner, Pedersen, Henriette, Jensen, Kamilla Ellermann, Villingshøj, Mette, Skjoth‐Rasmussen, Jane, Brennum, Jannick, Vitting‐Seerup, Kristoffer, Poulsen, Hans Skovgaard, Hamerlik, Petra

“…Glioblastoma (GBM) ranks among the most lethal cancers, with current therapies offering only palliation. Inter‐ and intrapatient heterogeneity is a hallmark of…”
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Inhibition of histone deacetylases sensitizes glioblastoma cells to lomustine by Staberg, Mikkel, Michaelsen, Signe Regner, Rasmussen, Rikke Darling, Villingshøj, Mette, Poulsen, Hans Skovgaard, Hamerlik, Petra

“…Purpose Glioblastoma (GBM) ranks among the deadliest solid cancers worldwide and its prognosis has remained dismal, despite the use of aggressive…”
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Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor by Christensen, Camilla L., Kwiatkowski, Nicholas, Abraham, Brian J., Carretero, Julian, Al-Shahrour, Fatima, Zhang, Tinghu, Chipumuro, Edmond, Herter-Sprie, Grit S., Akbay, Esra A., Altabef, Abigail, Zhang, Jianming, Shimamura, Takeshi, Capelletti, Marzia, Reibel, Jakob B., Cavanaugh, Jillian D., Gao, Peng, Liu, Yan, Michaelsen, Signe R., Poulsen, Hans S., Aref, Amir R., Barbie, David A., Bradner, James E., George, Rani E., Gray, Nathanael S., Young, Richard A., Wong, Kwok-Kin

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A Prognostic Model for Glioblastoma Patients Treated With Standard Therapy Based on a Prospective Cohort of Consecutive Non-Selected Patients From a Single Institution by Abedi, Armita Armina, Grunnet, Kirsten, Christensen, Ib Jarle, Michaelsen, Signe Regner, Muhic, Aida, Møller, Søren, Hasselbalch, Benedikte, Poulsen, Hans Skovgaard, Urup, Thomas

“…Glioblastoma patients administered standard therapies, comprising maximal surgical resection, radiation therapy with concomitant and adjuvant temozolomide,…”
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