Search Results - "Michael S. Glickman"

The mechanism of action of BCG therapy for bladder cancer—a current perspective by Redelman-Sidi, Gil, Glickman, Michael S., Bochner, Bernard H.

“…Key Points Despite nearly four decades of clinical experience with Bacillus Calmette–Guérin (BCG) for bladder cancer, the mechanism of its therapeutic effect…”
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Converting Cancer Therapies into Cures: Lessons from Infectious Diseases by Glickman, Michael S., Sawyers, Charles L.

“…During the past decade, cancer drug development has shifted from a focus on cytotoxic chemotherapies to drugs that target specific molecular alterations in…”
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Antibiotic treatment for Tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed by Wipperman, Matthew F., Fitzgerald, Daniel W., Juste, Marc Antoine Jean, Taur, Ying, Namasivayam, Sivaranjani, Sher, Alan, Bean, James M., Bucci, Vanni, Glickman, Michael S.

“…Mycobacterium tuberculosis , the cause of Tuberculosis (TB), infects one third of the world’s population and causes substantial mortality worldwide. In its…”
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The Microbiome and Tuberculosis: Early Evidence for Cross Talk by Namasivayam, Sivaranjani, Sher, Alan, Glickman, Michael S, Wipperman, Matthew F

“…Tuberculosis (TB) is an ancient infectious disease of humans that has been extensively studied both clinically and experimentally. Although susceptibility to…”
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An essential nonredundant role for mycobacterial DnaK in native protein folding by Fay, Allison, Glickman, Michael S

“…Protein chaperones are essential in all domains of life to prevent and resolve protein misfolding during translation and proteotoxic stress. HSP70 family…”
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Division of labor between SOS and PafBC in mycobacterial DNA repair and mutagenesis by Adefisayo, Oyindamola O, Dupuy, Pierre, Nautiyal, Astha, Bean, James M, Glickman, Michael S

“…Abstract DNA repair systems allow microbes to survive in diverse environments that compromise chromosomal integrity. Pathogens such as…”
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Structure of the M. tuberculosis DnaK−GrpE complex reveals how key DnaK roles are controlled by Xiao, Xiansha, Fay, Allison, Molina, Pablo Santos, Kovach, Amanda, Glickman, Michael S., Li, Huilin

“…The molecular chaperone DnaK is essential for viability of Mycobacterium tuberculosis (Mtb). DnaK hydrolyzes ATP to fold substrates, and the resulting ADP is…”
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Single-Cell Transcriptional Profiling Reveals Signatures of Helper, Effector, and Regulatory MAIT Cells during Homeostasis and Activation by Vorkas, Charles Kyriakos, Krishna, Chirag, Li, Kelin, Aubé, Jeffrey, Fitzgerald, Daniel W, Mazutis, Linas, Leslie, Christina S, Glickman, Michael S

“…Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that recognize microbial vitamin B metabolites and have emerging roles in infectious…”
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The Canonical Wnt Pathway Drives Macropinocytosis in Cancer by Redelman-Sidi, Gil, Binyamin, Anna, Gaeta, Isabella, Palm, Wilhelm, Thompson, Craig B, Romesser, Paul B, Lowe, Scott W, Bagul, Mukta, Doench, John G, Root, David E, Glickman, Michael S

“…Macropinocytosis has emerged as an important pathway of protein acquisition in cancer cells, particularly in tumors with activated Ras such as pancreatic and…”
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Distinctive roles of translesion polymerases DinB1 and DnaE2 in diversification of the mycobacterial genome through substitution and frameshift mutagenesis by Dupuy, Pierre, Ghosh, Shreya, Adefisayo, Oyindamola, Buglino, John, Shuman, Stewart, Glickman, Michael S.

“…Antibiotic resistance of Mycobacterium tuberculosis is exclusively a consequence of chromosomal mutations. Translesion synthesis (TLS) is a widely conserved…”
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Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA by Hubin, Elizabeth A, Fay, Allison, Xu, Catherine, Bean, James M, Saecker, Ruth M, Glickman, Michael S, Darst, Seth A, Campbell, Elizabeth A

“…RbpA and CarD are essential transcription regulators in mycobacteria. Mechanistic analyses of promoter open complex (RPo) formation establish that RbpA and…”
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Longitudinal profiling reveals a persistent intestinal dysbiosis triggered by conventional anti-tuberculosis therapy by Namasivayam, Sivaranjani, Maiga, Mamoudou, Yuan, Wuxing, Thovarai, Vishal, Costa, Diego L, Mittereder, Lara R, Wipperman, Matthew F, Glickman, Michael S, Dzutsev, Amiran, Trinchieri, Giorgio, Sher, Alan

“…Effective treatment of Mycobacterium tuberculosis (Mtb) infection requires at least 6 months of daily therapy with multiple orally administered antibiotics…”
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The DnaK Chaperone System Buffers the Fitness Cost of Antibiotic Resistance Mutations in Mycobacteria by Fay, Allison, Philip, John, Saha, Priya, Hendrickson, Ronald C, Glickman, Michael S, Burns-Huang, Kristin

“…Chaperones aid in protein folding and maintenance of protein integrity. In doing so, they have the unique ability to directly stabilize resistance-conferring…”
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Diisonitrile Lipopeptides Mediate Resistance to Copper Starvation in Pathogenic Mycobacteria by Buglino, John A., Ozakman, Yaprak, Xu, Yao, Chowdhury, Farhan, Tan, Derek S., Glickman, Michael S.

“…Bacterial pathogens and their hosts engage in intense competition for critical nutrients during infection, including metals such as iron, copper, and zinc…”
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Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU) by Li, Kelin, Vorkas, Charles K, Chaudhry, Ashutosh, Bell, Donielle L, Willis, Richard A, Rudensky, Alexander, Altman, John D, Glickman, Michael S, Aubé, Jeffrey

“…Mucosal-associated invariant T (MAIT) cells are an abundant class of innate T cells restricted by the MHC I-related molecule MR1. MAIT cells can recognize…”
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Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis by Wipperman, Matthew F., Bhattarai, Shakti K., Vorkas, Charles Kyriakos, Maringati, Venkata Suhas, Taur, Ying, Mathurin, Laurent, McAulay, Katherine, Vilbrun, Stalz Charles, Francois, Daphie, Bean, James, Walsh, Kathleen F., Nathan, Carl, Fitzgerald, Daniel W., Glickman, Michael S., Bucci, Vanni

“…The composition of the gastrointestinal microbiota influences systemic immune responses, but how this affects infectious disease pathogenesis and antibiotic…”
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Integrated sensing of host stresses by inhibition of a cytoplasmic two-component system controls M. tuberculosis acute lung infection by Buglino, John A, Sankhe, Gaurav D, Lazar, Nathaniel, Bean, James M, Glickman, Michael S

“…Bacterial pathogens that infect phagocytic cells must deploy mechanisms that sense and neutralize host microbicidal effectors. For , the causative agent of…”
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Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism by Peek, James, Lilic, Mirjana, Montiel, Daniel, Milshteyn, Aleksandr, Woodworth, Ian, Biggins, John B., Ternei, Melinda A., Calle, Paula Y., Danziger, Michael, Warrier, Thulasi, Saito, Kohta, Braffman, Nathaniel, Fay, Allison, Glickman, Michael S., Darst, Seth A., Campbell, Elizabeth A., Brady, Sean F.

“…Rifamycin antibiotics (Rifs) target bacterial RNA polymerases (RNAPs) and are widely used to treat infections including tuberculosis. The utility of these…”
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Function of site-2 proteases in bacteria and bacterial pathogens by Schneider, Jessica S., Glickman, Michael S.

“…Site-2 proteases (S2Ps) are a class of intramembrane metalloproteases named after the founding member of this protein family, human S2P, which control…”
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CarD Is an Essential Regulator of rRNA Transcription Required for Mycobacterium tuberculosis Persistence by Stallings, Christina L., Stephanou, Nicolas C., Chu, Linda, Hochschild, Ann, Nickels, Bryce E., Glickman, Michael S.

“…Mycobacterium tuberculosis is arguably the world's most successful infectious agent because of its ability to control its own cell growth within the host…”
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