Search Results - "Michael R. Bardsley"

Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract by Gomez-Pinilla, Pedro J, Gibbons, Simon J, Bardsley, Michael R, Lorincz, Andrea, Pozo, Maria J, Pasricha, Pankaj J, Van de Rijn, Matt, West, Robert B, Sarr, Michael G, Kendrick, Michael L, Cima, Robert R, Dozois, Eric J, Larson, David W, Ordog, Tamas, Farrugia, Gianrico

“…Populations of interstitial cells of Cajal (ICC) are altered in several gastrointestinal neuromuscular disorders. ICC are identified typically by…”
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Hyperglycemia Increases Interstitial Cells of Cajal via MAPK1 and MAPK3 Signaling to ETV1 and KIT, Leading to Rapid Gastric Emptying by Hayashi, Yujiro, Toyomasu, Yoshitaka, Saravanaperumal, Siva Arumugam, Bardsley, Michael R, Smestad, John A, Lorincz, Andrea, Eisenman, Seth T, Cipriani, Gianluca, Nelson Holte, Molly H, Al Khazal, Fatimah J, Syed, Sabriya A, Gajdos, Gabriella B, Choi, Kyoung Moo, Stoltz, Gary J, Miller, Katie E, Kendrick, Michael L, Rubin, Brian P, Gibbons, Simon J, Bharucha, Adil E, Linden, David R, Maher, Louis James, Farrugia, Gianrico, Ordog, Tamas

“…Background & Aims Depletion of interstitial cells of Cajal (ICCs) is common in diabetic gastroparesis. However, in approximately 20% of patients with diabetes,…”
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A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of KRAS-mediated cell growth by Fernandez-Zapico, Martin E, Lomberk, Gwen A, Tsuji, Shoichiro, DeMars, Cathrine J, Bardsley, Michael R, Lin, Yi-Hui, Almada, Luciana L, Han, Jing-Jing, Mukhopadhyay, Debabrata, Ordog, Tamas, Buttar, Navtej S, Urrutia, Raul

“…SP/KLF (Specificity protein/Krüppel-like factor) transcription factors comprise an emerging group of proteins that may behave as tumour suppressors…”
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Ano1 as a regulator of proliferation by Stanich, Jennifer E, Gibbons, Simon J, Eisenman, Seth T, Bardsley, Michael R, Rock, Jason R, Harfe, Brian D, Ordog, Tamas, Farrugia, Gianrico

“…Ano1 is a recently discovered Ca(2+)-activated Cl(-) channel expressed on interstitial cells of Cajal (ICC) that has been implicated in slow-wave activity in…”
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Progenitors of Interstitial Cells of Cajal in the Postnatal Murine Stomach by Lorincz, Andrea, Redelman, Doug, Horváth, Viktor J, Bardsley, Michael R, Chen, Hui, Ördög, Tamás

“…Background & Aims: Maintaining the integrity of networks of interstitial cells of Cajal (ICC) is essential to preserve orderly contractile activity and…”
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Differential gene expression in functional classes of interstitial cells of Cajal in murine small intestine by Chen, Hui, Ordog, Tamas, Chen, Junwei, Young, David L, Bardsley, Michael R, Redelman, Doug, Ward, Sean M, Sanders, Kenton M

“…1 Department of Physiology and Cell Biology 2 Cytometry Center, University of Nevada, Reno 3 Sierra Cytometry, Reno, Nevada Interstitial cells of Cajal (ICC)…”
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Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways by Hayashi, Yujiro, Asuzu, David T, Gibbons, Simon J, Aarsvold, Kirsten H, Bardsley, Michael R, Lomberk, Gwen A, Mathison, Angela J, Kendrick, Michael L, Shen, K Robert, Taguchi, Takahiro, Gupta, Anu, Rubin, Brian P, Fletcher, Jonathan A, Farrugia, Gianrico, Urrutia, Raul A, Ordog, Tamas

“…Stem cell factor (mouse: Kitl, human: KITLG) and insulin-like growth factor-1 (IGF1), acting via KIT and IGF1 receptor (IGF1R), respectively, are critical for…”
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Platelet-Derived Growth Factor Receptor-α Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in KIT by Stabilizing ETV1 by Hayashi, Yujiro, Bardsley, Michael R, Toyomasu, Yoshitaka, Milosavljevic, Srdjan, Gajdos, Gabriella B, Choi, Kyoung Moo, Reid-Lombardo, KMarie, Kendrick, Michael L, Bingener-Casey, Juliane, Tang, Chih-Min, Sicklick, Jason K, Gibbons, Simon J, Farrugia, Gianrico, Taguchi, Takahiro, Gupta, Anu, Rubin, Brian P, Fletcher, Jonathan A, Ramachandran, Abhijit, Ordog, Tamas

“…Background & Aims In gastrointestinal muscles, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT) is predominantly expressed by interstitial…”
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Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression by Tang, Chih-Min, Lee, Tracy E, Syed, Sabriya A, Burgoyne, Adam M, Leonard, Stephanie Y, Gao, Fei, Chan, Jonathan C, Shi, Eileen, Chmielecki, Juliann, Morosini, Deborah, Wang, Kai, Ross, Jeffrey S, Kendrick, Michael L, Bardsley, Michael R, Siena, Martina De, Mao, Junhao, Harismendy, Olivier, Ordog, Tamas, Sicklick, Jason K

“…Gastrointestinal stromal tumors (GIST) arise within the interstitial cell of Cajal (ICC) lineage due to activating KIT/PDGFRA mutations. Both ICC and GIST…”
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FAM96A is a novel pro‐apoptotic tumor suppressor in gastrointestinal stromal tumors by Schwamb, Bettina, Pick, Robert, Fernández, Sara Beatriz Mateus, Völp, Kirsten, Heering, Jan, Dötsch, Volker, Bösser, Susanne, Jung, Jennifer, Beinoraviciute‐Kellner, Rasa, Wesely, Josephine, Zörnig, Inka, Hammerschmidt, Matthias, Nowak, Matthias, Penzel, Roland, Zatloukal, Kurt, Joos, Stefan, Rieker, Ralf Joachim, Agaimy, Abbas, Söder, Stephan, Reid‐Lombardo, KMarie, Kendrick, Michael L., Bardsley, Michael R., Hayashi, Yujiro, Asuzu, David T., Syed, Sabriya A., Ordog, Tamas, Zörnig, Martin

“…The ability to escape apoptosis is a hallmark of cancer‐initiating cells and a key factor of resistance to oncolytic therapy. Here, we identify FAM96A as a…”
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Loss of Kitlow progenitors, reduced stem cell factor and high oxidative stress underlie gastric dysfunction in progeric mice by Izbeki, Ferenc, Asuzu, David T., Lorincz, Andrea, Bardsley, Michael R., Popko, Laura N., Choi, Kyoung Moo, Young, David L., Hayashi, Yujiro, Linden, David R., Kuro‐o, Makoto, Farrugia, Gianrico, Ordog, Tamas

“…Gastrointestinal functions decline with ageing leading to impaired quality of life, and increased morbidity and mortality. Neurodegeneration is believed to…”
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Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging by Hayashi, Yujiro, Asuzu, David T., Bardsley, Michael R., Gajdos, Gabriella B., Kvasha, Sergiy M., Linden, David R., Nagy, Rea A., Saravanaperumal, Siva Arumugam, Syed, Sabriya A., Toyomasu, Yoshitaka, Yan, Huihuang, Chini, Eduardo N., Gibbons, Simon J., Kellogg, Todd A., Khazaie, Khashayarsha, Kuro-o, Makoto, Machado Espindola Netto, Jair, Singh, Mahendra Pal, Tidball, James G., Wehling-Henricks, Michelle, Farrugia, Gianrico, Ordog, Tamas

“…Gastric dysfunction in the elderly may cause reduced food intake, frailty, and increased mortality. The pacemaker and neuromodulator cells interstitial cells…”
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113 Restoration of Kit Expression by Pharmacological Inhibition of Polycomb Group (PcG)-Mediated Epigenetic Repression in Interstitial Cells of Cajal (ICC) Subjected to Chronic Kit Ligand (Kitl) Withdrawal by Hayashi, Yujiro, Syed, Sabriya A, Bardsley, Michael R, Strege, Peter R, Farrugia, Gianrico, Ordog, Tamas

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125 Trp53 Mediates Stem Cell Depletion From Chronically Elevated Canonical Wnt Signaling by Asuzu, David T, Hayashi, Yujiro, Toyomasu, Yoshitaka, Bardsley, Michael R, Farrugia, Gianrico, Ordog, Tamas

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Tu1166 Salinomycin Enhances Imatinib Effects in Murine Interstitial Cell of Cajal (ICC) Stem Cells and Gastrointestinal Stromal Tumor (GIST) Cells and Inhibits Glycosylation of Kit Protein While Triggering Expression of Truncated Intracellular Kit by Hayashi, Yujiro, Gibbons, Simon J, Bardsley, Michael R, Taguchi, Takahiro, Farrugia, Gianrico, Rubin, Brian P, Ordog, Tamas

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124 Effects of Crenolanib, a Highly Selective Platelet-Derived Growth Factor Receptor α/β (PDGFRA/B) Tyrosine Kinase Inhibitor, on the Proliferation of Kii-Mutant Gastrointestinal Stromal Tumor (GIST) Cells and Interstitial Cell of Cajal (ICC) Precursors by Hayashi, Yujiro, Bardsley, Michael R, Toyomasu, Yoshitaka, Choi, Kyoung Moo, Taguchi, Takahiro, Ramachandran, Abhijit, Gibbons, Simon J, Farrugia, Gianrico, Ordog, Tamas

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275 Adult Stem Cells for Murine Interstitial Cells of Cajal (ICC) Mediate Immunosuppression In Vitro by Dave, Maneesh, Hayashi, Yujiro, Khanna, Sahil, Bardsley, Michael R, Svingen, Phyllis A, Faubion, William A, Ordog, Tamas

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Tu1886 Autophagy and Multidrug Resistance Limit the Efficacy of Salinomycin (Sal) in Gastrointestinal Stromal Tumor (GIST) Cells and Stem Cells (SC) for Interstitial Cells of Cajal (ICC) by Nagy, Rea A, Watson, Emma, Hayashi, Yujiro, Bardsley, Michael R, Strege, Peter R, Taguchi, Takahiro, Gibbons, Simon J, Farrugia, Gianrico, Asuzu, David T, Ordog, Tamas

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Persistent β-Catenin Activation Underlies Senescence of Interstitial Cell of Cajal (ICC) Stem Cells in Naturally Aging Mice by Asuzu, David T, Hayashi, Yujiro, Bardsley, Michael R, Farrugia, Gianrico, Ordog, Tamas

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Protein Kinase Cγ Mediates Regulation of Proliferation by the Serotonin 5-Hydroxytryptamine Receptor 2B by Wouters, Mira M., Roeder, Jaime L., Tharayil, Vivek S., Stanich, Jennifer E., Strege, Peter R., Lei, Sha, Bardsley, Michael R., Ordog, Tamas, Gibbons, Simon J., Farrugia, Gianrico

“…Activation of the 5-hydroxytryptamine receptor 2B (5-HT2B), a Gq/11 protein-coupled receptor, results in proliferation of various cell types. The 5-HT2B…”
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