Search Results - "Michael Pride"

Safety, Tolerability, and Immunogenicity of a 20-Valent Pneumococcal Conjugate Vaccine (PCV20) in Adults 60 to 64 Years of Age by Hurley, Donald, Griffin, Carl, Young, Mariano, Scott, Daniel A, Pride, Michael W, Scully, Ingrid L, Ginis, John, Severs, Joseph, Jansen, Kathrin U, Gruber, William C, Watson, Wendy

“…Pneumococcal conjugate vaccines (PCVs) have significantly decreased pneumococcal disease worldwide; however, expanding serotype coverage may further reduce…”
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Pivotal Phase 3 Randomized Clinical Trial of the Safety, Tolerability, and Immunogenicity of 20-Valent Pneumococcal Conjugate Vaccine in Adults Aged ≥18 Years by Essink, Brandon, Sabharwal, Charu, Cannon, Kevin, Frenck, Robert, Lal, Himal, Xu, Xia, Sundaraiyer, Vani, Peng, Yahong, Moyer, Lisa, Pride, Michael W, Scully, Ingrid L, Jansen, Kathrin U, Gruber, William C, Scott, Daniel A, Watson, Wendy

“…Pneumococcal conjugate vaccines (PCVs) have significantly reduced pneumococcal disease, but disease from non-PCV serotypes remains. The safety, tolerability,…”
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Sex differences in social interaction behavior following social defeat stress in the monogamous California mouse (Peromyscus californicus) by Trainor, Brian C, Pride, Michael C, Villalon Landeros, Rosalina, Knoblauch, Nicholas W, Takahashi, Elizabeth Y, Silva, Andrea L, Crean, Katie K

“…Stressful life experiences are known to be a precipitating factor for many mental disorders. The social defeat model induces behavioral responses in rodents…”
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Autism-specific maternal autoantibodies produce behavioral abnormalities in an endogenous antigen-driven mouse model of autism by Jones, Karen L., Pride, Michael C., Edmiston, Elizabeth, Yang, Mu, Silverman, Jill L., Crawley, Jacqueline N., Van de Water, Judy

“…Immune dysregulation has been noted consistently in individuals with autism spectrum disorder (ASD) and their families, including the presence of…”
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Polysaccharide Conjugate Vaccine against Pneumococcal Pneumonia in Adults by Bonten, Marc J.M, Huijts, Susanne M, Bolkenbaas, Marieke, Webber, Chris, Patterson, Scott, Gault, Samantha, van Werkhoven, Cornelis H, van Deursen, Anna M.M, Sanders, Elisabeth A.M, Verheij, Theo J.M, Patton, Michael, McDonough, Anne, Moradoghli-Haftvani, Anita, Smith, Helen, Mellelieu, Tracey, Pride, Michael W, Crowther, Graham, Schmoele-Thoma, Beate, Scott, Daniel A, Jansen, Kathrin U, Lobatto, Rita, Oosterman, Bas, Visser, Nils, Caspers, Esther, Smorenburg, Andre, Emini, Emilio A, Gruber, William C, Grobbee, Diederick E

“…In this double-blind, placebo-controlled trial involving more than 84,000 Dutch adults, the 13-valent pneumococcal conjugate vaccine was found to prevent…”
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A phase 1, placebo-controlled, randomized study of the safety, tolerability, and immunogenicity of a Clostridium difficile vaccine administered with or without aluminum hydroxide in healthy adults by Sheldon, Eric, Kitchin, Nicholas, Peng, Yahong, Eiden, Joseph, Gruber, William, Johnson, Erik, Jansen, Kathrin U, Pride, Michael W, Pedneault, Louise

“…Highlights • Phase 1 study of a toxoid A and B vaccine in healthy adults aged 50–85 years. • Immunogenicity was present after Dose 2, with an anamnestic…”
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A Phase 2 Study Evaluating the Safety, Tolerability, and Immunogenicity of Two 3-Dose Regimens of a Clostridium difficile Vaccine in Healthy US Adults Aged 65 to 85 Years by Kitchin, Nicholas, Remich, Shon A, Peterson, James, Peng, Yahong, Gruber, William C, Jansen, Kathrin U, Pride, Michael W, Anderson, Annaliesa S, Knirsch, Charles, Webber, Chris

“…Abstract Background Clostridium difficile causes toxin-mediated nosocomial diarrhea and community-acquired infections; no preventive vaccine is licensed. In…”
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Expanded Analysis of 20 Pneumococcal Serotypes Associated With Radiographically Confirmed Community-acquired Pneumonia in Hospitalized US Adults by Isturiz, Raul, Grant, Lindsay, Gray, Sharon, Alexander-Parrish, Ronika, Jiang, Qin, Jodar, Luis, Peyrani, Paula, Ford, Kimbal D, Pride, Michael W, Self, Wesley H, Counselman, Francis, Volturo, Gregory, Ostrosky-Zeichner, Luis, Wunderink, Richard G, Sherwin, Robert, Overcash, J Scott, File, Thomas, Ramirez, Julio

“…Streptococcus pneumoniae is a causative agent of community-acquired pneumonia (CAP). The 13-valent pneumococcal conjugate vaccine (PCV13) has significantly…”
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Germline Chd8 haploinsufficiency alters brain development in mouse by Gompers, Andrea L, Su-Feher, Linda, Ellegood, Jacob, Copping, Nycole A, Riyadh, M Asrafuzzaman, Stradleigh, Tyler W, Pride, Michael C, Schaffler, Melanie D, Wade, A Ayanna, Catta-Preta, Rinaldo, Zdilar, Iva, Louis, Shreya, Kaushik, Gaurav, Mannion, Brandon J, Plajzer-Frick, Ingrid, Afzal, Veena, Visel, Axel, Pennacchio, Len A, Dickel, Diane E, Lerch, Jason P, Crawley, Jacqueline N, Zarbalis, Konstantinos S, Silverman, Jill L, Nord, Alex S

“…Strong genetic evidence points to a significant role for heterozygous mutations to general chromatin remodeling factors, such as CHD8, in autism. Gompers et al…”
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Multicountry Review of Streptococcus pneumoniae Serotype Distribution Among Adults With Community-Acquired Pneumonia by Grant, Lindsay R, Begier, Elizabeth, Theilacker, Christian, Barry, Rachid, Hall-Murray, Cassandra, Yan, Qi, Pope, Veneta, Pride, Michael W, Jodar, Luis, Gessner, Bradford D

“…Abstract Background Nonbacteremic community-acquired pneumonia (CAP) is a leading presentation of severe pneumococcal disease in adults. Serotype-specific…”
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Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size by Le Duc, Diana, Giulivi, Cecilia, Hiatt, Susan M, Napoli, Eleonora, Panoutsopoulos, Alexios, Harlan De Crescenzo, Angelo, Kotzaeridou, Urania, Syrbe, Steffen, Anagnostou, Evdokia, Azage, Meron, Bend, Renee, Begtrup, Amber, Brown, Natasha J, Büttner, Benjamin, Cho, Megan T, Cooper, Gregory M, Doering, Jan H, Dubourg, Christèle, Everman, David B, Hildebrand, Michael S, Santos, Francis Jeshira Reynoso, Kellam, Barbara, Keller-Ramey, Jennifer, Lemke, Johannes R, Liu, Shuxi, Niyazov, Dmitriy, Payne, Katelyn, Person, Richard, Quélin, Chloé, Schnur, Rhonda E, Smith, Brooke T, Strober, Jonathan, Walker, Susan, Wallis, Mathew, Walsh, Laurence, Yang, Sandra, Yuen, Ryan K C, Ziegler, Andreas, Sticht, Heinrich, Pride, Michael C, Orosco, Lori, Martínez-Cerdeño, Verónica, Silverman, Jill L, Crawley, Jacqueline N, Scherer, Stephen W, Zarbalis, Konstantinos S, Jamra, Rami

“…The underpinnings of mild to moderate neurodevelopmental delay remain elusive, often leading to late diagnosis and interventions. Here, we present data on…”
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Surveillance of pneumococcal serotypes in adults hospitalised with acute lower respiratory tract infection in Bristol, UK by Hyams, Catherine, Lahuerta, Maria, Theilacker, Christian, King, Jade, Adegbite, David, McGuinness, Serena, Grimes, Charli, Campling, James, Southern, Jo, Pride, Michael W., Begier, Elizabeth, Maskell, Nick, Oliver, Jennifer, Jodar, Luis, Gessner, Bradford D., Finn, Adam

“…Pneumococcus remains a major cause of adult lower respiratory tract infections (LRTI). Few data exist on the relative contribution of serotypes included in…”
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Effects of kappa opioid receptors on conditioned place aversion and social interaction in males and females by Robles, Cindee F., McMackin, Marissa Z., Campi, Katharine L., Doig, Ian E., Takahashi, Elizabeth Y., Pride, Michael C., Trainor, Brian C.

“…•Low doses of kappa opioid receptor agonist induced place aversion in females but not males.•Acute effects of kappa agonist on social interaction behavior are…”
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A Phase 2 Extension Study Evaluating the Immunogenicity, Safety, and Tolerability of 3 or 4 Doses of a Clostridioides difficile Vaccine in Healthy US Adults Aged 65 to 85 Years by Remich, Shon, Kitchin, Nicholas, Peterson, James, Li, Ping, Pride, Michael W, Brock, Linda, Anderson, Annaliesa S, Gruber, William C, Jansen, Kathrin U, Lockhart, Stephen P, Webber, Chris

“…Abstract Background This phase 2 extension explored the long-term antibody persistence of an investigational Clostridioides difficile vaccine and the safety,…”
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Qualification and Clinical Validation of an Immunodiagnostic Assay for Detecting 11 Additional Streptococcus pneumoniae Serotype–specific Polysaccharides in Human Urine by Kalina, Warren V, Souza, Victor, Wu, Kangjian, Giardina, Peter, McKeen, Andrew, Jiang, Qin, Tan, Charles, French, Roger, Ren, Yanhua, Belanger, Kelly, McElhiney, Susan, Unnithan, Manu, Cheng, Huiming, Mininni, Terri, Giordano-Schmidt, Donna, Gessner, Bradford D, Jansen, Kathrin U, Pride, Michael W

“…Abstract Background Identifying Streptococcus pneumoniae serotypes by urinary antigen detection (UAD) assay is the most sensitive way to evaluate the…”
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Cognitive deficits in the Snord116 deletion mouse model for Prader-Willi syndrome by Adhikari, Anna, Copping, Nycole A., Onaga, Beth, Pride, Michael C., Coulson, Rochelle L., Yang, Mu, Yasui, Dag H., LaSalle, Janine M., Silverman, Jill L.

“…•A lack of the gene cluster SNORD116 may be responsible for some aspects of PWS.•Heterozygous Snord116 mutation mice had learning and memory deficits in three…”
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Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism by Dhamne, Sameer C, Silverman, Jill L, Super, Chloe E, Lammers, Stephen H T, Hameed, Mustafa Q, Modi, Meera E, Copping, Nycole A, Pride, Michael C, Smith, Daniel G, Rotenberg, Alexander, Crawley, Jacqueline N, Sahin, Mustafa

“…Autism spectrum disorder (ASD) is a clinically and biologically heterogeneous condition characterized by social, repetitive, and sensory behavioral…”
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Neuronal overexpression of Ube3a isoform 2 causes behavioral impairments and neuroanatomical pathology relevant to 15q11.2-q13.3 duplication syndrome by Copping, Nycole A, Christian, Sarah G B, Ritter, Dylan J, Islam, M Saharul, Buscher, Nathalie, Zolkowska, Dorota, Pride, Michael C, Berg, Elizabeth L, LaSalle, Janine M, Ellegood, Jacob, Lerch, Jason P, Reiter, Lawrence T, Silverman, Jill L, Dindot, Scott V

“…Maternally derived copy number gains of human chromosome 15q11.2-q13.3 (Dup15q syndrome or Dup15q) cause intellectual disability, epilepsy, developmental…”
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A phase 3 study evaluating the lot consistency, immunogenicity, safety, and tolerability of a Clostridioides difficile vaccine in healthy adults 65 to 85 years of age by Christensen, Shane, Bouguermouh, Salim, Ilangovan, Kumar, Pride, Michael W, Webber, Chris, Lockhart, Stephen P, Shah, Rupal, Kitchin, Nicholas, Lamberth, Erik, Zhang, Haiying, Gao, Qi, Brock, Linda, Anderson, Annaliesa S, Gruber, William C

“…A toxoid-based Clostridioides difficile vaccine is currently in development. Here, we report lot-to-lot consistency, immunogenicity, safety, and tolerability…”
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Pneumococcal epidemiology among us adults hospitalized for community-acquired pneumonia by Isturiz, Raul E., Ramirez, Julio, Self, Wesley H., Grijalva, Carlos G., Counselman, Francis L., Volturo, Gregory, Ostrosky-Zeichner, Luis, Peyrani, Paula, Wunderink, Richard G., Sherwin, Robert, Overcash, J. Scott, Oliva, Senen Pena, File, Thomas, Wiemken, Timothy L., McLaughlin, John M., Pride, Michael W., Gray, Sharon, Alexander, Ronika, Ford, Kimbal D., Jiang, Qin, Jodar, Luis

“…Few studies have measured the burden of adult pneumococcal disease after the introduction of 13-valent pneumococcal conjugate vaccine (PCV13) into the US…”
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