Search Results - "Michael J. Welsh"

Enhancing glycolysis attenuates Parkinson's disease progression in models and clinical databases by Cai, Rong, Zhang, Yu, Simmering, Jacob E, Schultz, Jordan L, Li, Yuhong, Fernandez-Carasa, Irene, Consiglio, Antonella, Raya, Angel, Polgreen, Philip M, Narayanan, Nandakumar S, Yuan, Yanpeng, Chen, Zhiguo, Su, Wenting, Han, Yanping, Zhao, Chunyue, Gao, Lifang, Ji, Xunming, Welsh, Michael J, Liu, Lei

“…Parkinson's disease (PD) is a common neurodegenerative disease that lacks therapies to prevent progressive neurodegeneration. Impaired energy metabolism and…”
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Acidic pH increases airway surface liquid viscosity in cystic fibrosis by Tang, Xiao Xiao, Ostedgaard, Lynda S, Hoegger, Mark J, Moninger, Thomas O, Karp, Philip H, McMenimen, James D, Choudhury, Biswa, Varki, Ajit, Stoltz, David A, Welsh, Michael J

“…Cystic fibrosis (CF) disrupts respiratory host defenses, allowing bacterial infection, inflammation, and mucus accumulation to progressively destroy the lungs…”
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Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala by Du, Jianyang, Reznikov, Leah R., Price, Margaret P., Zha, Xiang-ming, Lu, Yuan, Moninger, Thomas O., Wemmie, John A., Welsh, Michael J.

“…Stimulating presynaptic terminals can increase the proton concentration in synapses. Potential receptors for protons are acid-sensing ion channels (ASICs), Na…”
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Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis by Hoegger, Mark J., Fischer, Anthony J., McMenimen, James D., Ostedgaard, Lynda S., Tucker, Alex J., Awadalla, Maged A., Moninger, Thomas O., Michalski, Andrew S., Hoffman, Eric A., Zabner, Joseph, Stoltz, David A., Welsh, Michael J.

“…Lung disease in people with cystic fibrosis (CF) is initiated by defective host defense that predisposes airways to bacterial infection. Advanced CF is…”
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Airway acidification initiates host defense abnormalities in cystic fibrosis mice by Shah, Viral S., Meyerholz, David K., Tang, Xiao Xiao, Reznikov, Leah, Alaiwa, Mahmoud Abou, Ernst, Sarah E., Karp, Philip H., Wohlford-Lenane, Christine L., Heilmann, Kristopher P., Leidinger, Mariah R., Allen, Patrick D., Zabner, Joseph, McCray, Paul B., Ostedgaard, Lynda S., Stoltz, David A., Randak, Christoph O., Welsh, Michael J.

“…Cystic fibrosis (CF) is caused by mutations in the gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. In humans…”
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Motile Cilia of Human Airway Epithelia Are Chemosensory by Shah, Alok S, Ben-Shahar, Yehuda, Moninger, Thomas O, Kline, Joel N, Welsh, Michael J

“…Cilia are microscopic projections that extend from eukaryotic cells. There are two general types of cilia; primary cilia serve as sensory organelles, whereas…”
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Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung by Pezzulo, Alejandro A., Tang, Xiao Xiao, Hoegger, Mark J., Abou Alaiwa, Mahmoud H., Ramachandran, Shyam, Moninger, Thomas O., Karp, Phillip H., Wohlford-Lenane, Christine L., Haagsman, Henk P., van Eijk, Martin, Bánfi, Botond, Horswill, Alexander R., Stoltz, David A., McCray, Paul B., Welsh, Michael J., Zabner, Joseph

“…In a porcine cystic fibrosis model, lack of cystic fibrosis transmembrane conductance regulator (CFTR) is shown to result in acidification of airway surface…”
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pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37 by Alaiwa, Mahmoud H. Abou, Reznikov, Leah R., Gansemer, Nicholas D., Sheets, Kelsey A., Horswill, Alexander R., Stoltz, David A., Zabner, Joseph, Welsh, Michael J.

“…Significance Although lungs are continuously bombarded by bacteria, pulmonary defense mechanisms normally keep them sterile. Those defenses include a complex…”
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Gel-forming mucins form distinct morphologic structures in airways by Ostedgaard, Lynda S., Moninger, Thomas O., McMenimen, James D., Sawin, Nicholas M., Parker, Connor P., Thornell, Ian M., Powers, Linda S., Gansemer, Nicholas D., Bouzek, Drake C., Cook, Daniel P., Meyerholz, David K., Alaiwa, Mahmoud H. Abou, Stoltz, David A., Welsh, Michael J.

“…Gel-forming mucins, the primary macromolecular components of airway mucus, facilitate airway clearance by mucociliary transport. In cystic fibrosis (CF)…”
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Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity by Kreple, Collin J, Lu, Yuan, Taugher, Rebecca J, Schwager-Gutman, Andrea L, Du, Jianyang, Stump, Madeliene, Wang, Yimo, Ghobbeh, Ali, Fan, Rong, Cosme, Caitlin V, Sowers, Levi P, Welsh, Michael J, Radley, Jason J, LaLumiere, Ryan T, Wemmie, John A

“…Exposure to psychostimulants such as cocaine induces synaptic plasticity within the nucleus accumbens (NAc) and alters behavior. Here the authors find a new…”
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CFTR-rich ionocytes mediate chloride absorption across airway epithelia by Lei, Lei, Traore, Soumba, Romano Ibarra, Guillermo S, Karp, Philip H, Rehman, Tayyab, Meyerholz, David K, Zabner, Joseph, Stoltz, David A, Sinn, Patrick L, Welsh, Michael J, McCray, Jr, Paul B, Thornell, Ian M

“…The volume and composition of a thin layer of liquid covering the airway surface defend the lung from inhaled pathogens and debris. Airway epithelia secrete…”
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Inflammation as a Regulator of the Airway Surface Liquid pH in Cystic Fibrosis by Rehman, Tayyab, Welsh, Michael J

“…The airway surface liquid (ASL) is a thin sheet of fluid that covers the luminal aspect of the airway epithelium. The ASL is a site of several first-line host…”
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ppk23-Dependent chemosensory functions contribute to courtship behavior in Drosophila melanogaster by Lu, Beika, LaMora, Angela, Sun, Yishan, Welsh, Michael J, Ben-Shahar, Yehuda

“…Insects utilize diverse families of ion channels to respond to environmental cues and control mating, feeding, and the response to threats. Although…”
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Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system by Friese, Manuel A, Etzensperger, Ruth, Craner, Matthew J, Wemmie, John A, Welsh, Michael J, Fugger, Lars, Vergo, Sandra, Vincent, Angela

“…Multiple sclerosis is a neuroinflammatory disease associated with axonal degeneration. The neuronally expressed, proton-gated acid-sensing ion channel-1…”
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Combining Ivacaftor and Intensive Antibiotics Achieves Limited Clearance of Cystic Fibrosis Infections by Durfey, Samantha L, Pipavath, Sudhakar, Li, Anna, Vo, Anh T, Ratjen, Anina, Carter, Suzanne, Morgan, Sarah J, Radey, Matthew C, Grogan, Brenda, Salipante, Stephen J, Welsh, Michael J, Stoltz, David A, Goss, Christopher H, McKone, Edward F, Singh, Pradeep K

“…Drugs called CFTR modulators improve the physiologic defect underlying cystic fibrosis (CF) and alleviate many disease manifestations. However, studies to date…”
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Detecting activity-evoked pH changes in human brain by Magnotta, Vincent A, Heo, Hye-Young, Dlouhy, Brian J, Dahdaleh, Nader S, Follmer, Robin L, Thedens, Daniel R, Welsh, Michael J, Wemmie, John A

“…Localized pH changes have been suggested to occur in the brain during normal function. However, the existence of such pH changes has also been questioned. Lack…”
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TRPA channels distinguish gravity sensing from hearing in Johnston's organ by Sun, Yishan, Liu, Lei, Ben-Shahar, Yehuda, Jacobs, Julie S, Eberl, Daniel F, Welsh, Michael J

“…Although many animal species sense gravity for spatial orientation, the molecular bases remain uncertain. Therefore, we studied Drosophila melanogaster, which…”
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Human cystic fibrosis airway epithelia have reduced Cl−conductance but not increased Na+conductance by Itani, Omar A., Chen, Jeng-Haur, Karp, Philip H., Ernst, Sarah, Keshavjee, Shaf, Parekh, Kalpaj, Klesney-Tait, Julia, Zabner, Joseph, Welsh, Michael J.

“…Loss of cystic fibrosis transmembrane conductance regulator (CFTR) anion channel function causes cystic fibrosis (CF) lung disease. CFTR is expressed in airway…”
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microRNA network regulates expression and biosynthesis of wild-type and ΔF508 mutant cystic fibrosis transmembrane conductance regulator by Ramachandran, Shyam, Karp, Philip H, Jiang, Peng, Ostedgaard, Lynda S, Walz, Amy E, Fisher, John T, Keshavjee, Shaf, Lennox, Kim A, Jacobi, Ashley M, Rose, Scott D, Behlke, Mark A, Welsh, Michael J, Xing, Yi, McCray, Paul B

“…Production of functional proteins requires multiple steps, including gene transcription and posttranslational processing. MicroRNAs (miRNAs) can regulate…”
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The Ion Channel ASIC2 Is Required for Baroreceptor and Autonomic Control of the Circulation by Lu, Yongjun, Ma, Xiuying, Sabharwal, Rasna, Snitsarev, Vladislav, Morgan, Donald, Rahmouni, Kamal, Drummond, Heather A., Whiteis, Carol A., Costa, Vivian, Price, Margaret, Benson, Christopher, Welsh, Michael J., Chapleau, Mark W., Abboud, François M.

“…Arterial baroreceptors provide a neural sensory input that reflexly regulates the autonomic drive of circulation. Our goal was to test the hypothesis that a…”
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