Search Results - "Michael J. Owen"

New Approaches to Psychiatric Diagnostic Classification by Owen, Michael J.

“…Recent findings in psychiatric genetics have crystallized concerns that diagnostic categories used in the clinic map poorly onto the underlying biology. If we…”
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Schizophrenia and the neurodevelopmental continuum:evidence from genomics by Owen, Michael J., O'Donovan, Michael C.

“…The idea that disturbances occurring early in brain development contribute to the pathogenesis of schizophrenia, often referred to as the neurodevelopmental…”
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The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia by Howes, Oliver D, McCutcheon, Robert, Owen, Michael J, Murray, Robin M

“…Abstract The dopamine hypothesis is the longest standing pathoetiologic theory of schizophrenia. Because it was initially based on indirect evidence and…”
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The implications of the shared genetics of psychiatric disorders by O'Donovan, Michael C, Owen, Michael J

“…Recent studies have led to the identification of genetic loci that are shared between psychiatric disorders. Here O’Donovan and Owen argue that it is unlikely…”
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Translating insights from neuropsychiatric genetics and genomics for precision psychiatry by Rees, Elliott, Owen, Michael J

“…The primary aim of precision medicine is to tailor healthcare more closely to the needs of individual patients. This requires progress in two areas: the…”
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Novel Findings from CNVs Implicate Inhibitory and Excitatory Signaling Complexes in Schizophrenia by Pocklington, Andrew J., Rees, Elliott, Walters, James T.R., Han, Jun, Kavanagh, David H., Chambert, Kimberly D., Holmans, Peter, Moran, Jennifer L., McCarroll, Steven A., Kirov, George, O’Donovan, Michael C., Owen, Michael J.

“…We sought to obtain novel insights into schizophrenia pathogenesis by exploiting the association between the disorder and chromosomal copy number (CNV) burden…”
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Genetic Risk for Schizophrenia: Convergence on Synaptic Pathways Involved in Plasticity by Hall, Jeremy, Trent, Simon, Thomas, Kerrie L, O’Donovan, Michael C, Owen, Michael J

“…Abstract Recent large-scale genomic studies have revealed two broad classes of risk alleles for schizophrenia: a polygenic component of risk mediated through…”
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Deflection by kinetic impact: Sensitivity to asteroid properties by Bruck Syal, Megan, Michael Owen, J., Miller, Paul L.

“…•We use Adaptive SPH to model the deflection of asteroids by kinetic impactors.•Asteroid cohesion, porosity, and shape significantly affect momentum…”
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Neurodevelopmental hypothesis of schizophrenia by Owen, Michael J., O'Donovan, Michael C., Thapar, Anita, Craddock, Nicholas

“…The neurodevelopmental hypothesis of schizophrenia provided a valuable framework that allowed a condition that usually presents with frank disorder in…”
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Definition and description of schizophrenia in the DSM-5 by Tandon, Rajiv, Gaebel, Wolfgang, Barch, Deanna M, Bustillo, Juan, Gur, Raquel E, Heckers, Stephan, Malaspina, Dolores, Owen, Michael J, Schultz, Susan, Tsuang, Ming, Van Os, Jim, Carpenter, William

“…Abstract Although dementia praecox or schizophrenia has been considered a unique disease for over a century, its definitions and boundaries have changed over…”
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Genomic insights into schizophrenia by Owen, Michael J

“…Schizophrenia is a common, complex, heterogeneous psychiatric syndrome which can have profound impacts on affected individuals and imposes significant burdens…”
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A Population-Based Cohort Study Examining the Incidence and Impact of Psychotic Experiences From Childhood to Adulthood, and Prediction of Psychotic Disorder by Sullivan, Sarah A, Kounali, Daphne, Cannon, Mary, David, Anthony S, Fletcher, Paul C, Holmans, Peter, Jones, Hannah, Jones, Peter B, Linden, David E.J, Lewis, Glyn, Owen, Michael J, O’Donovan, Michael, Rammos, Alexandros, Thompson, Andrew, Wolke, Dieter, Heron, Jon, Zammit, Stanley

“…Objective:The authors investigated the incidence, course, and outcome of psychotic experiences from childhood through early adulthood in the general population…”
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Intellectual disability and major psychiatric disorders: A continuum of neurodevelopmental causality by Owen, Michael J.

“…There is accumulating evidence for shared genetic as well as environmental risk between intellectual disability and other conditions with a neurodevelopmental…”
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A compatibly differenced total energy conserving form of SPH by Michael Owen, J.

“…SUMMARYWe describe a modified form of smoothed particle hydrodynamics (SPH) in which the specific thermal energy equation is based on a compatibly differenced…”
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Cognitive Performance Among Carriers of Pathogenic Copy Number Variants: Analysis of 152,000 UK Biobank Subjects by Kendall, Kimberley M, Rees, Elliott, Escott-Price, Valentina, Einon, Mark, Thomas, Rhys, Hewitt, Jonathan, O’Donovan, Michael C, Owen, Michael J, Walters, James T.R, Kirov, George

“…Abstract Background The UK Biobank is a unique resource for biomedical research, with extensive phenotypic and genetic data on half a million adults from the…”
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Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders by Heyes, Samuel, Pratt, Wendy S, Rees, Elliott, Dahimene, Shehrazade, Ferron, Laurent, Owen, Michael J, Dolphin, Annette C

“…This review summarises genetic studies in which calcium channel genes have been connected to the spectrum of neuropsychiatric syndromes, from bipolar disorder…”
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Cognitive performance and functional outcomes of carriers of pathogenic copy number variants: analysis of the UK Biobank by Kendall, Kimberley M., Bracher-Smith, Matthew, Fitzpatrick, Harry, Lynham, Amy, Rees, Elliott, Escott-Price, Valentina, Owen, Michael J., O'Donovan, Michael C., Walters, James T.R., Kirov, George

“…Rare copy number variants (CNVs) are associated with risk of neurodevelopmental disorders characterised by varying degrees of cognitive impairment, including…”
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Increasing the Clinical Psychiatric Knowledge Base About Pathogenic Copy Number Variation by Sullivan, Patrick F, Owen, Michael J

“…Specific copy number variants (CXVs) have been robustly associated with intellectual disability, autism, and schizophrenia. Most of the focus in the literature…”
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Medical consequences of pathogenic CNVs in adults: analysis of the UK Biobank by Crawford, Karen, Bracher-Smith, Matthew, Owen, David, Kendall, Kimberley M, Rees, Elliott, Pardiñas, Antonio F, Einon, Mark, Escott-Price, Valentina, Walters, James T R, O'Donovan, Michael C, Owen, Michael J, Kirov, George

“…Genomic CNVs increase the risk for early-onset neurodevelopmental disorders, but their impact on medical outcomes in later life is still poorly understood. The…”
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Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis by Williams, Nigel M, Dr, Zaharieva, Irina, BSc, Martin, Andrew, BSc, Langley, Kate, PhD, Mantripragada, Kiran, PhD, Fossdal, Ragnheidur, PhD, Stefansson, Hreinn, PhD, Stefansson, Kari, MD, Magnusson, Pall, MD, Gudmundsson, Olafur O, MD, Gustafsson, Omar, PhD, Holmans, Peter, Prof, Owen, Michael J, Prof, O'Donovan, Michael, Prof, Thapar, Anita, Prof

“…Summary Background Large, rare chromosomal deletions and duplications known as copy number variants (CNVs) have been implicated in neurodevelopmental disorders…”
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