Search Results - "Michael F. Hirshman"

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle by Sinha, Manisha, Jang, Young C., Oh, Juhyun, Khong, Danika, Wu, Elizabeth Y., Manohar, Rohan, Miller, Christine, Regalado, Samuel G., Loffredo, Francesco S., Pancoast, James R., Hirshman, Michael F., Lebowitz, Jessica, Shadrach, Jennifer L., Cerletti, Massimiliano, Kim, Mi-Jeong, Serwold, Thomas, Goodyear, Laurie J., Rosner, Bernard, Lee, Richard T., Wagers, Amy J.

“…Parabiosis experiments indicate that impaired regeneration in aged mice is reversible by exposure to a young circulation, suggesting that young blood contains…”
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A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis by Stanford, Kristin I, Middelbeek, Roeland J W, Townsend, Kristy L, Lee, Min-Young, Takahashi, Hirokazu, So, Kawai, Hitchcox, Kristen M, Markan, Kathleen R, Hellbach, Katharina, Hirshman, Michael F, Tseng, Yu-Hua, Goodyear, Laurie J

“…Exercise training improves whole-body glucose homeostasis through effects largely attributed to adaptations in skeletal muscle; however, training also affects…”
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Differential Role of Insulin/IGF-1 Receptor Signaling in Muscle Growth and Glucose Homeostasis by O’Neill, Brian T., Lauritzen, Hans P.M.M., Hirshman, Michael F., Smyth, Graham, Goodyear, Laurie J., Kahn, C. Ronald

“…Insulin and insulin-like growth factor 1 (IGF-1) are major regulators of muscle protein and glucose homeostasis. To determine how these pathways interact,…”
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12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat by Leiria, Luiz Osório, Wang, Chih-Hao, Lynes, Matthew D., Yang, Kunyan, Shamsi, Farnaz, Sato, Mari, Sugimoto, Satoru, Chen, Emily Y., Bussberg, Valerie, Narain, Niven R., Sansbury, Brian E., Darcy, Justin, Huang, Tian Lian, Kodani, Sean D., Sakaguchi, Masaji, Rocha, Andréa L., Schulz, Tim J., Bartelt, Alexander, Hotamisligil, Gökhan S., Hirshman, Michael F., van Leyen, Klaus, Goodyear, Laurie J., Blüher, Matthias, Cypess, Aaron M., Kiebish, Michael A., Spite, Matthew, Tseng, Yu-Hua

“…Distinct oxygenases and their oxylipin products have been shown to participate in thermogenesis by mediating physiological adaptations required to sustain body…”
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JNK regulates muscle remodeling via myostatin/SMAD inhibition by Lessard, Sarah J., MacDonald, Tara L., Pathak, Prerana, Han, Myoung Sook, Coffey, Vernon G., Edge, Johann, Rivas, Donato A., Hirshman, Michael F., Davis, Roger J., Goodyear, Laurie J.

“…Skeletal muscle has a remarkable plasticity to adapt and remodel in response to environmental cues, such as physical exercise. Endurance exercise stimulates…”
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Exercise before and during pregnancy prevents the deleterious effects of maternal high-fat feeding on metabolic health of male offspring by Stanford, Kristin I, Lee, Min-Young, Getchell, Kristen M, So, Kawai, Hirshman, Michael F, Goodyear, Laurie J

“…The intrauterine environment during pregnancy is a critical factor in the development of diabetes and obesity in offspring. To determine the effects of…”
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Maternal Exercise Improves Glucose Tolerance in Female Offspring by Stanford, Kristin I, Takahashi, Hirokazu, So, Kawai, Alves-Wagner, Ana Barbara, Prince, Noah B, Lehnig, Adam C, Getchell, Kristen M, Lee, Min-Young, Hirshman, Michael F, Goodyear, Laurie J

“…Poor maternal diet can lead to metabolic disease in offspring, whereas maternal exercise may have beneficial effects on offspring health. In this study, we…”
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Paternal Exercise Improves Glucose Metabolism in Adult Offspring by Stanford, Kristin I, Rasmussen, Morten, Baer, Lisa A, Lehnig, Adam C, Rowland, Leslie A, White, Joseph D, So, Kawai, De Sousa-Coelho, Ana Luisa, Hirshman, Michael F, Patti, Mary-Elizabeth, Rando, Oliver J, Goodyear, Laurie J

“…Poor paternal diet has emerged as a risk factor for metabolic disease in offspring, and alterations in sperm may be a major mechanism mediating these…”
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Characterization of an acute muscle contraction model using cultured C2C12 myotubes by Manabe, Yasuko, Miyatake, Shouta, Takagi, Mayumi, Nakamura, Mio, Okeda, Ai, Nakano, Taemi, Hirshman, Michael F, Goodyear, Laurie J, Fujii, Nobuharu L

“…A cultured C2C12 myotube contraction system was examined for application as a model for acute contraction-induced phenotypes of skeletal muscle. C2C12 myotubes…”
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Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis by O'Neill, Brian T, Lee, Kevin Y, Klaus, Katherine, Softic, Samir, Krumpoch, Megan T, Fentz, Joachim, Stanford, Kristin I, Robinson, Matthew M, Cai, Weikang, Kleinridders, Andre, Pereira, Renata O, Hirshman, Michael F, Abel, E Dale, Accili, Domenico, Goodyear, Laurie J, Nair, K Sreekumaran, Kahn, C Ronald

“…Diabetes strongly impacts protein metabolism, particularly in skeletal muscle. Insulin and IGF-1 enhance muscle protein synthesis through their receptors, but…”
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Exercise and Regulation of Carbohydrate Metabolism by Mul, Joram D, Stanford, Kristin I, Hirshman, Michael F, Goodyear, Laurie J

“…Carbohydrates are the preferred substrate for contracting skeletal muscles during high-intensity exercise and are also readily utilized during moderate…”
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Highly Efficient, Functional Engraftment of Skeletal Muscle Stem Cells in Dystrophic Muscles by Cerletti, Massimiliano, Jurga, Sara, Witczak, Carol A., Hirshman, Michael F., Shadrach, Jennifer L., Goodyear, Laurie J., Wagers, Amy J.

“…Satellite cells reside beneath the basal lamina of skeletal muscle fibers and include cells that act as precursors for muscle growth and repair. Although they…”
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Maternal Exercise-Induced SOD3 Reverses the Deleterious Effects of Maternal High-Fat Diet on Offspring Metabolism Through Stabilization of H3K4me3 and Protection Against WDR82 Carbonylation by Kusuyama, Joji, Makarewicz, Nathan S, Albertson, Brent G, Alves-Wagner, Ana Barbara, Conlin, Royce H, Prince, Noah B, Alves, Christiano R R, Ramachandran, Krithika, Kozuka, Chisayo, Xiudong, Yang, Xia, Yang, Hirshman, Michael F, Hatta, Toshihisa, Nagatomi, Ryoichi, Nozik, Eva S, Goodyear, Laurie J

“…Preclinical studies reveal maternal exercise as a promising intervention to reduce the transmission of multigenerational metabolic dysfunction caused by…”
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Exercise training and cold exposure trigger distinct molecular adaptations to inguinal white adipose tissue by Vamvini, Maria, Nigro, Pasquale, Caputo, Tiziana, Stanford, Kristin I., Hirshman, Michael F., Middelbeek, Roeland J.W., Goodyear, Laurie J.

“…Exercise training and cold exposure both improve systemic metabolism, but the mechanisms are not well established. Here, we tested the hypothesis that inguinal…”
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Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix by Nigro, Pasquale, Vamvini, Maria, Yang, Jiekun, Caputo, Tiziana, Ho, Li-Lun, Carbone, Nicholas P., Papadopoulos, Danae, Conlin, Royce, He, Jie, Hirshman, Michael F., White, Joseph D., Robidoux, Jacques, Hickner, Robert C., Nielsen, Søren, Pedersen, Bente K., Kellis, Manolis, Middelbeek, Roeland J.W., Goodyear, Laurie J.

“…Inguinal white adipose tissue (iWAT) is essential for the beneficial effects of exercise training on metabolic health. The underlying mechanisms for these…”
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Effects of exercise training on subcutaneous and visceral adipose tissue in normal- and high-fat diet-fed rats by Gollisch, Katja S C, Brandauer, Josef, Jessen, Niels, Toyoda, Taro, Nayer, Ali, Hirshman, Michael F, Goodyear, Laurie J

“…Regular physical activity improves glucose tolerance and decreases adiposity. Our aim was to investigate the effects of exercise training on subcutaneous…”
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Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle by Vichaiwong, Kanokwan, Purohit, Suneet, An, Ding, Toyoda, Taro, Jessen, Niels, Hirshman, Michael F, Goodyear, Laurie J

“…TBC1D1 (tre-2/USP6, BUB2, cdc16 domain family member 1) is a Rab-GAP (GTPase-activating protein) that is highly expressed in skeletal muscle, but little is…”
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Disconnecting Mitochondrial Content from Respiratory Chain Capacity in PGC-1-Deficient Skeletal Muscle by Rowe, Glenn C., Patten, Ian S., Zsengeller, Zsuzsanna K., El-Khoury, Riyad, Okutsu, Mitsuharu, Bampoh, Sophia, Koulisis, Nicole, Farrell, Caitlin, Hirshman, Michael F., Yan, Zhen, Goodyear, Laurie J., Rustin, Pierre, Arany, Zolt

“…The transcriptional coactivators PGC-1α and PGC-1β are widely thought to be required for mitochondrial biogenesis and fiber typing in skeletal muscle. Here, we…”
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TBC1D1 Regulates Insulin- and Contraction-Induced Glucose Transport in Mouse Skeletal Muscle by DING AN, TOYODA, Taro, TAYLOR, Eric B, HAIYAN YU, FUJII, Nobuharu, HIRSHMAN, Michael F, GOODYEAR, Laurie J

“…TBC1D1 is a member of the TBC1 Rab-GTPase family of proteins and is highly expressed in skeletal muscle. Insulin and contraction increase TBC1D1…”
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Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism by Li, Mengyao Ella, Lauritzen, Hans P. M. M., O’Neill, Brian T., Wang, Chih-Hao, Cai, Weikang, Brandao, Bruna B., Sakaguchi, Masaji, Tao, Rongya, Hirshman, Michael F., Softic, Samir, Kahn, C. Ronald

“…Skeletal muscle insulin resistance, decreased phosphatidylinositol 3-kinase (PI3K) activation and altered mitochondrial function are hallmarks of type 2…”
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