Search Results - "Michael Edwardson, J."

Modes of action of the archaeal Mre11/Rad50 DNA-repair complex revealed by fast-scan atomic force microscopy by Zabolotnaya, Ekaterina, Mela, Ioanna, Williamson, Mark J., Bray, Sian M., Yau, Siu Kei, Papatziamou, Dimitra, Edwardson, J. Michael, Robinson, Nicholas P., Henderson, Robert M.

“…Mre11 and Rad50 (M/R) proteins are part of an evolutionarily conserved macromolecular apparatus that maintains genomic integrity through repair pathways. Prior…”
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Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation by Sim, M. F. Michelle, Persiani, Elisa, Talukder, Md. Mesbah Uddin, Mcilroy, George D., Roumane, Ahlima, Edwardson, J. Michael, Rochford, Justin J.

“…Seipin deficiency causes severe congenital generalized lipodystrophy (CGL) and metabolic disease. However, how seipin regulates adipocyte development and…”
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Sar1 GTPase Activity Is Regulated by Membrane Curvature by Hanna, Michael G., Mela, Ioanna, Wang, Lei, Henderson, Robert M., Chapman, Edwin R., Edwardson, J. Michael, Audhya, Anjon

“…The majority of biosynthetic secretory proteins initiate their journey through the endomembrane system from specific subdomains of the endoplasmic reticulum…”
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Linker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission by Liu, Huisheng, Bai, Hua, Xue, Renhao, Takahashi, Hirohide, Edwardson, J Michael, Chapman, Edwin R

“…Rapid vesicle exocytosis requires the Ca 2+ sensor synaptotagmin I (syt). Here the AUs manipulate the length and rigidity of the linker connecting the two Ca…”
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The Transient Receptor Potential Channels TRPP2 and TRPC1 Form a Heterotetramer with a 2:2 Stoichiometry and an Alternating Subunit Arrangement by Kobori, Toshiro, Smith, Graham D., Sandford, Richard, Edwardson, J.Michael

“…There is functional evidence that polycystin-2 (TRPP2) interacts with other members of the transient receptor potential family, including TRPC1 and TRPV4. Here…”
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Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors by Dawe, G. Brent, Kadir, Md. Fahim, Venskutonytė, Raminta, Perozzo, Amanda M., Yan, Yuhao, Alexander, Ryan P.D., Navarrete, Camilo, Santander, Eduardo A., Arsenault, Marika, Fuentes, Christian, Aurousseau, Mark R.P., Frydenvang, Karla, Barrera, Nelson P., Kastrup, Jette S., Edwardson, J. Michael, Bowie, Derek

“…Neurotransmitter-gated ion channels are allosteric proteins that switch on and off in response to agonist binding. Most studies have focused on the…”
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Hrs and STAM Function Synergistically to Bind Ubiquitin-Modified Cargoes In Vitro by Takahashi, Hirohide, Mayers, Jonathan R., Wang, Lei, Edwardson, J. Michael, Audhya, Anjon

“…The turnover of integral membrane proteins requires a specialized transport pathway mediated by components of the endosomal sorting complex required for…”
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Analysis of naturally occurring mutations in the human lipodystrophy protein seipin reveals multiple potential pathogenic mechanisms by Sim, M. F. Michelle, Talukder, M. Mesbah Uddin, Dennis, Rowena J., O’Rahilly, Stephen, Edwardson, J. Michael, Rochford, Justin J.

“…Aims/hypothesis In humans, disruption of the gene BSCL2 , encoding the protein seipin, causes congenital generalised lipodystrophy (CGL) with severe insulin…”
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Analysis of Assembly and Trafficking of Native P2X4 and P2X7 Receptor Complexes in Rodent Immune Cells by Boumechache, Miyyada, Masin, Marianela, Edwardson, J. Michael, Górecki, Dariusz C., Murrell-Lagnado, Ruth

“…P2X4 and P2X7 are the predominant P2X receptor subtypes expressed in immune cells. Having previously shown a structural and functional interaction between the…”
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Atomic Force Microscopy Reveals the Architecture of the Epithelial Sodium Channel (ENaC) by Stewart, Andrew P., Haerteis, Silke, Diakov, Alexei, Korbmacher, Christoph, Edwardson, J. Michael

“…The epithelial sodium channel (ENaC) is a member of the ENaC/degenerin superfamily. ENaC is a heteromultimer containing three homologous subunits (α, β, and…”
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Atomic force microscopy (AFM) imaging suggests that stromal interaction molecule 1 (STIM1) binds to Orai1 with sixfold symmetry by Balasuriya, Dilshan, Srivats, Shyam, Murrell-Lagnado, Ruth D., Edwardson, J. Michael

“…•The subunit stoichiometry of the CRAC channel is controversial.•AFM imaging shows that Orai1 assembles as a hexamer.•STIM1 binds to Orai1 with sixfold…”
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Compound Exocytosis: Mechanisms and Functional Significance by Pickett, James A., Edwardson, J. Michael

“…Compound exocytosis occurs in many cell types. It represents a specialized form of secretion in which vesicles undergo fusion with each other as well as with…”
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Demonstration of a Direct Interaction between σ-1 Receptors and Acid-Sensing Ion Channels by Carnally, Stewart M., Johannessen, Molly, Henderson, Robert M., Jackson, Meyer B., Edwardson, J. Michael

“…The σ-1 receptor is a widely expressed protein that interacts with a variety of ion channels, including the acid-sensing ion channel (ASIC) 1a. Here we used…”
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An alternating GluN1-2-1-2 subunit arrangement in mature NMDA receptors by Riou, Morgane, Stroebel, David, Edwardson, J Michael, Paoletti, Pierre

“…NMDA receptors (NMDARs) form glutamate-gated ion channels that play a critical role in CNS physiology and pathology. Together with AMPA and kainate receptors,…”
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Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis by Talukder, Md. Mesbah Uddin, Sim, M.F. Michelle, O'Rahilly, Stephen, Edwardson, J. Michael, Rochford, Justin J

“…Abstract Objective Disruption of the genes encoding either seipin or 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) causes severe congenital…”
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ESCRT-0 Assembles as a Heterotetrameric Complex on Membranes and Binds Multiple Ubiquitinylated Cargoes Simultaneously by Mayers, Jonathan R., Fyfe, Ian, Schuh, Amber L., Chapman, Edwin R., Edwardson, J. Michael, Audhya, Anjon

“…The ESCRT machinery consists of multiple protein complexes that collectively participate in the biogenesis of multivesicular endosomes (MVEs). The ESCRT-0…”
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Real-Time Analysis of the Effects of Cholesterol on Lipid Raft Behavior Using Atomic Force Microscopy by Lawrence, Jared C., Saslowsky, David E., Michael Edwardson, J., Henderson, Robert M.

“…Cholesterol plays a crucial role in cell membranes, and has been implicated in the assembly and maintenance of sphingolipid-rich rafts. We have examined the…”
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Direct visualization of G-quadruplexes in DNA using atomic force microscopy by Neaves, Kelly J, Huppert, Julian L, Henderson, Robert M, Edwardson, J. Michael

“…The formation of G-quadruplexes in G-rich regions of DNA is believed to affect DNA transcription and replication. However, it is currently unclear how this…”
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Receptor binding enables botulinum neurotoxin B to sense low pH for translocation channel assembly by Sun, Shihu, Suresh, Swetha, Liu, Huisheng, Tepp, William H, Johnson, Eric A, Edwardson, J Michael, Chapman, Edwin R

“…Botulinum neurotoxins (BoNTs, serotypes A-G), elaborated by Clostridium botulinum, can induce lethal paralysis and are classified as Category A bioterrorism…”
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Coordinated regulation of the ESCRT-III component CHMP4C by the chromosomal passenger complex and centralspindlin during cytokinesis by Capalbo, Luisa, Mela, Ioanna, Abad, Maria Alba, Jeyaprakash, A. Arockia, Edwardson, J. Michael, D'Avino, Pier Paolo

“…The chromosomal passenger complex (CPC)—composed of Aurora B kinase, Borealin, Survivin and INCENP—surveys the fidelity of genome segregation throughout cell…”
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