Search Results - "Michael A Hollingsworth"

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver by Costa-Silva, Bruno, Aiello, Nicole M., Ocean, Allyson J., Singh, Swarnima, Zhang, Haiying, Thakur, Basant Kumar, Becker, Annette, Hoshino, Ayuko, Mark, Milica Tešić, Molina, Henrik, Xiang, Jenny, Zhang, Tuo, Theilen, Till-Martin, García-Santos, Guillermo, Williams, Caitlin, Ararso, Yonathan, Huang, Yujie, Rodrigues, Gonçalo, Shen, Tang-Long, Labori, Knut Jørgen, Lothe, Inger Marie Bowitz, Kure, Elin H., Hernandez, Jonathan, Doussot, Alexandre, Ebbesen, Saya H., Grandgenett, Paul M., Hollingsworth, Michael A., Jain, Maneesh, Mallya, Kavita, Batra, Surinder K., Jarnagin, William R., Schwartz, Robert E., Matei, Irina, Peinado, Héctor, Stanger, Ben Z., Bromberg, Jacqueline, Lyden, David

“…Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis, mainly due to delayed detection. We hypothesized that intercellular…”
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Emerging roles of the CXCL12/CXCR4 axis in pancreatic cancer progression and therapy by Sleightholm, Richard L, Neilsen, Beth K, Li, Jing, Steele, Maria M, Singh, Rakesh K, Hollingsworth, Michael A, Oupicky, David

“…Chemokine networks regulate a variety of cellular, physiological, and immune processes. These normal functions can become appropriated by cancer cells to…”
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Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis by Roe, Jae-Seok, Hwang, Chang-Il, Somerville, Tim D.D., Milazzo, Joseph P., Lee, Eun Jung, Da Silva, Brandon, Maiorino, Laura, Tiriac, Hervé, Young, C. Megan, Miyabayashi, Koji, Filippini, Dea, Creighton, Brianna, Burkhart, Richard A., Buscaglia, Jonathan M., Kim, Edward J., Grem, Jean L., Lazenby, Audrey J., Grunkemeyer, James A., Hollingsworth, Michael A., Grandgenett, Paul M., Egeblad, Mikala, Park, Youngkyu, Tuveson, David A., Vakoc, Christopher R.

“…Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human malignancies, owing in part to its propensity for metastasis. Here, we used an organoid…”
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Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle by Wang, Gang, Biswas, Anup K., Ma, Wanchao, Kandpal, Manoj, Coker, Courtney, Grandgenett, Paul M., Hollingsworth, Michael A., Jain, Rinku, Tanji, Kurenai, Lόpez-Pintado, Sara, Borczuk, Alain, Hebert, Doreen, Jenkitkasemwong, Supak, Hojyo, Shintaro, Davuluri, Ramana V., Knutson, Mitchell D., Fukada, Toshiyuki, Acharyya, Swarnali

“…Patients with metastatic cancer experience a severe loss of skeletal muscle mass and function known as cachexia. Cachexia is associated with poor prognosis and…”
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Immature truncated O-glycophenotype of cancer directly induces oncogenic features by Radhakrishnan, Prakash, Dabelsteen, Sally, Madsen, Frey Brus, Francavilla, Chiara, Kopp, Katharina L, Steentoft, Catharina, Vakhrushev, Sergey Y, Olsen, Jesper V, Hansen, Lars, Bennett, Eric P, Woetmann, Anders, Yin, Guangliang, Chen, Longyun, Song, Haiyan, Bak, Mads, Hlady, Ryan A, Peters, Staci L, Opavsky, Rene, Thode, Christenze, Qvortrup, Klaus, Schjoldager, Katrine T-B G, Clausen, Henrik, Hollingsworth, Michael A, Wandall, Hans H

“…Aberrant expression of immature truncated O-glycans is a characteristic feature observed on virtually all epithelial cancer cells, and a very high frequency is…”
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A Combination of MUC5AC and CA19-9 Improves the Diagnosis of Pancreatic Cancer: A Multicenter Study by Kaur, Sukhwinder, Smith, Lynette M, Patel, Asish, Menning, Melanie, Watley, Duncan C, Malik, Saad S, Krishn, Shiv Ram, Mallya, Kavita, Aithal, Abhijit, Sasson, Aaron R, Johansson, Sonny L, Jain, Maneesh, Singh, Shailender, Guha, Sushovan, Are, Chandrakanth, Raimondo, Massimo, Hollingsworth, Michael A, Brand, Randall E, Batra, Surinder K

“…Pancreatic cancer (PC) is a lethal malignancy that lacks specific diagnostic markers. The present study explores the diagnostic potential of the most…”
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Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer by BAILEY, Jennifer M, SWANSON, Benjamin J, HAMADA, Tomofumi, EGGERS, John P, SINGH, Pankaj K, CAFFERY, Thomas, OUELLETTE, Michel M, HOLLINGSWORTH, Michael A

“…Purpose: We investigated the contribution of Sonic hedgehog (SHH) to pancreatic cancer progression. Experimental Design: We expressed SHH in a transformed…”
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Mucins in cancer: protection and control of the cell surface by Hollingsworth, Michael A, Swanson, Benjamin J

“…Mucins -- large extracellular proteins that are heavily glycosylated with complex oligosaccharides -- establish a selective molecular barrier at the epithelial…”
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Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma by Fox, Raymond G., Lytle, Nikki K., Jaquish, Dawn V., Park, Frederick D., Ito, Takahiro, Bajaj, Jeevisha, Koechlein, Claire S., Zimdahl, Bryan, Yano, Masato, Kopp, Janel L., Kritzik, Marcie, Sicklick, Jason K., Sander, Maike, Grandgenett, Paul M., Hollingsworth, Michael A., Shibata, Shinsuke, Pizzo, Donald, Valasek, Mark A., Sasik, Roman, Scadeng, Miriam, Okano, Hideyuki, Kim, Youngsoo, MacLeod, A. Robert, Lowy, Andrew M., Reya, Tannishtha

“…The stem cell determinant Musashi (Msi) is a key mediator of pancreatic cancer progression and therapy resistance. Musashi protein target in pancreatic cancer…”
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MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer by Chaika, Nina V, Gebregiworgis, Teklab, Lewallen, Michelle E, Purohit, Vinee, Radhakrishnan, Prakash, Liu, Xiang, Zhang, Bo, Mehla, Kamiya, Brown, Roger B, Caffrey, Thomas, Yu, Fang, Johnson, Keith R, Powers, Robert, Hollingsworth, Michael A, Singh, Pankaj K

“…Aberrant glucose metabolism is one of the hallmarks of cancer that facilitates cancer cell survival and proliferation. Here, we demonstrate that MUC1, a large,…”
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Effects of interobserver and interdisciplinary segmentation variabilities on CT-based radiomics for pancreatic cancer by Wong, Jeffrey, Baine, Michael, Wisnoskie, Sarah, Bennion, Nathan, Zheng, Dechun, Yu, Lei, Dalal, Vipin, Hollingsworth, Michael A., Lin, Chi, Zheng, Dandan

“…Radiomics is a method to mine large numbers of quantitative imaging features and develop predictive models. It has shown exciting promise for improved cancer…”
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Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins by Bailey, Jennifer M., Singh, Pankaj K., Hollingsworth, Michael A.

“…This review will highlight the significance of three critical pathways in developmental biology and our emerging understanding of their roles in regulating…”
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Microfluidic immunocapture of circulating pancreatic cells using parallel EpCAM and MUC1 capture: characterization, optimization and downstream analysis by Thege, Fredrik I, Lannin, Timothy B, Saha, Trisha N, Tsai, Shannon, Kochman, Michael L, Hollingsworth, Michael A, Rhim, Andrew D, Kirby, Brian J

“…We have developed and optimized a microfluidic device platform for the capture and analysis of circulating pancreatic cells (CPCs) and pancreatic circulating…”
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Pathobiological implications of MUC16 expression in pancreatic cancer by Haridas, Dhanya, Chakraborty, Subhankar, Ponnusamy, Moorthy P, Lakshmanan, Imayavaramban, Rachagani, Satyanarayana, Cruz, Eric, Kumar, Sushil, Das, Srustidhar, Lele, Subodh M, Anderson, Judy M, Wittel, Uwe A, Hollingsworth, Michael A, Batra, Surinder K

“…MUC16 (CA125) belongs to a family of high-molecular weight O-glycosylated proteins known as mucins. While MUC16 is well known as a biomarker in ovarian cancer,…”
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Cancer Biomarkers Defined by Autoantibody Signatures to Aberrant O-Glycopeptide Epitopes by WANDALL, Hans H, BLIXT, Ola, BURCHELL, Joy, CLAUSEN, Henrik, TARP, Mads A, PEDERSEN, Johannes W, BENNETT, Eric P, MANDEL, Ulla, RAGUPATHI, Govind, LIVINGSTON, Phil O, HOLLINGSWORTH, Michael A, TAYLOR-PAPADIMITRIOU, Joyce

“…Autoantibodies to cancer antigens hold promise as biomarkers for early detection of cancer. Proteins that are aberrantly processed in cancer cells are likely…”
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Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation by Somerville, Tim Dd, Biffi, Giulia, Daßler-Plenker, Juliane, Hur, Stella K, He, Xue-Yan, Vance, Krysten E, Miyabayashi, Koji, Xu, Yali, Maia-Silva, Diogo, Klingbeil, Olaf, Demerdash, Osama E, Preall, Jonathan B, Hollingsworth, Michael A, Egeblad, Mikala, Tuveson, David A, Vakoc, Christopher R

“…A highly aggressive subset of pancreatic ductal adenocarcinomas undergo trans-differentiation into the squamous lineage during disease progression. Here, we…”
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radioGWAS links radiome to genome to discover driver genes with somatic mutations for heterogeneous tumor image phenotype in pancreatic cancer by Zheng, Dandan, Grandgenett, Paul M., Zhang, Qi, Baine, Michael, Shi, Yu, Du, Qian, Liang, Xiaoying, Wong, Jeffrey, Iqbal, Subhan, Preuss, Kiersten, Kamal, Ahsan, Yu, Hongfeng, Du, Huijing, Hollingsworth, Michael A., Zhang, Chi

“…Addressing the significant level of variability exhibited by pancreatic cancer necessitates the adoption of a systems biology approach that integrates…”
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Truncated O-Glycan-Bearing MUC16 Enhances Pancreatic Cancer Cells Aggressiveness via α4β1 Integrin Complexes and FAK Signaling by Rajesh, Christabelle, Sagar, Satish, Rathinavel, Ashok Kumar, Chemparathy, Divya Thomas, Peng, Xianlu Laura, Yeh, Jen Jen, Hollingsworth, Michael A, Radhakrishnan, Prakash

“…Elevated levels of Mucin-16 (MUC16) in conjunction with a high expression of truncated O-glycans is implicated in playing crucial roles in the malignancy of…”
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An intravenous pancreatic cancer therapeutic: Characterization of CRISPR/Cas9n-modified Clostridium novyi-Non Toxic by Dailey, Kaitlin M, Small, James M, Pullan, Jessica E, Winfree, Seth, Vance, Krysten E, Orr, Megan, Mallik, Sanku, Bayles, Kenneth W, Hollingsworth, Michael A, Brooks, Amanda E

“…Clostridium novyi has demonstrated selective efficacy against solid tumors largely due to the microenvironment contained within dense tumor cores. The core of…”
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Differential expression of metabolic genes in tumor and stromal components of primary and metastatic loci in pancreatic adenocarcinoma by Chaika, Nina V, Yu, Fang, Purohit, Vinee, Mehla, Kamiya, Lazenby, Audrey J, DiMaio, Dominick, Anderson, Judy M, Yeh, Jen Jen, Johnson, Keith R, Hollingsworth, Michael A, Singh, Pankaj K

“…Pancreatic cancer is the fourth leading cause of cancer related deaths in the United States with a five-year survival rate of 6%. It is characterized by…”
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