Search Results - "Michael, W. Matthew"

Characterization of factors that underlie transcriptional silencing in C. elegans oocytes by Belew, Mezmur D, Chien, Emilie, Michael, W Matthew

“…While it has been appreciated for decades that prophase-arrested oocytes are transcriptionally silenced on a global level, the molecular pathways that promote…”
Get full text

MRN-dependent and independent pathways for recruitment of TOPBP1 to DNA double-strand breaks by Montales, Katrina, Ruis, Kenna, Lindsay, Howard, Michael, W. Matthew

“…A taxia T elangiectasia mutated and R AD3-related (ATR) kinase is activated by DNA replication stress and also by various forms of DNA damage, including DNA…”
Get full text

Direct Binding to Replication Protein A (RPA)-coated Single-stranded DNA Allows Recruitment of the ATR Activator TopBP1 to Sites of DNA Damage by Acevedo, Julyana, Yan, Shan, Michael, W. Matthew

“…A critical event for the ability of cells to tolerate DNA damage and replication stress is activation of the ATR kinase. ATR activation is dependent on the…”
Get full text

Structure-function analysis of TOPBP1’s role in ATR signaling using the DSB-mediated ATR activation in Xenopus egg extracts (DMAX) system by Montales, Katrina, Kim, Ahhyun, Ruis, Kenna, Michael, W. Matthew

“…The protein kinase ATR is activated at sites of DNA double-strand breaks where it plays important roles in promoting DNA end resection and regulating cell…”
Get full text

Zygotic Genome Activation Triggers Chromosome Damage and Checkpoint Signaling in C. elegans Primordial Germ Cells by Butuči, Melina, Williams, Ashley B., Wong, Matthew M., Kramer, Brendan, Michael, W. Matthew

“…Recent findings have identified highly transcribed genes as a source of genome instability; however, the degree to which large-scale shifts in transcriptional…”
Get full text

Cell-Type Specific Responses to DNA Replication Stress in Early C. elegans Embryos by Stevens, Holly, Williams, Ashley B, Michael, W Matthew

“…To better understand how the cellular response to DNA replication stress is regulated during embryonic development, we and others have established the early C…”
Get full text

TopBP1 and DNA polymerase alpha-mediated recruitment of the 9-1-1 complex to stalled replication forks: Implications for a replication restart-based mechanism for ATR checkpoint activation by Yan, Shan, Michael, W. Matthew

“…Upon sensing DNA damage or replication stress, cells trigger checkpoint response pathways that control cell cycle progression and maintain genomic stability. A…”
Get full text

Continued primer synthesis at stalled replication forks contributes to checkpoint activation by Van, Christopher, Yan, Shan, Michael, W. Matthew, Waga, Shou, Cimprich, Karlene A.

“…Stalled replication forks activate and are stabilized by the ATR (ataxia-telangiectasia mutated and Rad3 related)-mediated checkpoint, but ultimately, they…”
Get full text

Ubiquitin/SUMO modification of PCNA promotes replication fork progression in Xenopus laevis egg extracts by Leach, Craig A, Michael, W. Matthew

“…The homotrimeric DNA replication protein proliferating cell nuclear antigen (PCNA) is regulated by both ubiquitylation and sumoylation. We study the appearance…”
Get full text

Checkpoint silencing during the DNA damage response in Caenorhabditis elegans embryos by Holway, Antonia H, Kim, Seung-Hwan, La Volpe, Adriana, Michael, W. Matthew

“…In most cells, the DNA damage checkpoint delays cell division when replication is stalled by DNA damage. In early Caenorhabditis elegans embryos, however, the…”
Get full text

A global chromatin compaction pathway that represses germline gene expression during starvation by Belew, Mezmur D, Chien, Emilie, Wong, Matthew, Michael, W Matthew

“…While much is known about how transcription is controlled at individual genes, comparatively little is known about how cells regulate gene expression on a…”
Get full text

The Xenopus Xmus101 Protein Is Required for the Recruitment of Cdc45 to Origins of DNA Replication by Van Hatten, Ruth A., Tutter, Antonin V., Holway, Antonia H., Khederian, Alyssa M., Walter, Johannes C., Michael, W. Matthew

“…The initiation of eukaryotic DNA replication involves origin recruitment and activation of the MCM2-7 complex, the putative replicative helicase…”
Get full text

NBS1 binds directly to TOPBP1 via disparate interactions between the NBS1 BRCT1 domain and the TOPBP1 BRCT1 and BRCT2 domains by Huynh, Oanh, Ruis, Kenna, Montales, Katrina, Michael, W. Matthew

“…The TOPBP1 and NBS1 proteins are key components of DNA repair and DNA-based signaling systems. TOPBP1 is a multi-BRCT domain containing protein that plays…”
Get full text

Activation of the DNA Replication Checkpoint through RNA Synthesis by Primase by Michael, W. Matthew, Ott, Robert, Fanning, Ellen, Newport, John

“…When DNA replication is inhibited during the synthesis (S) phase of the cell cycle, a signaling pathway (checkpoint) is activated that serves to prevent…”
Get full text

Cyclin CYB-3 controls both S-phase and mitosis and is asymmetrically distributed in the early C. elegans embryo by Michael, W Matthew

“…In early C. elegans embryos the timing of cell division is both invariant and developmentally regulated, yet how the cell cycle is controlled in the embryo and…”
Get full text

Delineation of a minimal topoisomerase II binding protein 1 for regulated activation of ATR at DNA double-strand breaks by Ruis, Kenna, Huynh, Oanh, Montales, Katrina, Barr, Nina A., Michael, W. Matthew

“…Topoisomerase II Binding Protein 1 (TOPBP1) is an important activator of the DNA damage response kinase Ataxia Telangiectasia and Rad3-related (ATR), although…”
Get full text

The topoisomerase II/condensin II axis silences transcription during germline specification in Caenorhabditis elegans by Belew, Mezmur D, Chien, Emilie, Wong, Matthew, Michael, W Matthew

“…Abstract In Caenorhabditis elegans, the germline is specified via a preformation mechanism that relies on the PIE-1 protein's ability to globally silence mRNA…”
Get full text

TopBP1 and DNA polymerase-α directly recruit the 9-1-1 complex to stalled DNA replication forks by Yan, Shan, Michael, W. Matthew

“…TopBP1 and the Rad9-Rad1-Hus1 (9-1-1) complex activate the ataxia telangiectasia mutated and Rad3-related (ATR) protein kinase at stalled replication forks…”
Get full text

Biochemical analysis of TOPBP1 oligomerization by Kim, Ahhyun, Montales, Katrina, Ruis, Kenna, Senebandith, Holly, Gasparyan, Hovik, Cowan, Quinn, Michael, W. Matthew

“…•The ATR activator TOPBP1 oligomerizes via BRCT-BRCT domain interactions.•TOPBP1 oligomers can still bind heterologous binding partners.•The TOPBP1 AAD…”
Get full text

Transcriptional repression during spermatogenesis in C. elegans requires TOP-2, condensin II, and the MET-2 H3K9 methyltransferase by Chien, Emilie, Michael, W Matthew

“…In RNA polymerase II (RNAPII) transcription is globally repressed as oocytes prepare for meiosis. Recent work has identified the transcriptional repressors…”
Get full text