Search Results - "Michael, Sherryll L."

Effect of Inhibitors of Nitric Oxide Synthase on Acetaminophen-Induced Hepatotoxicity in Mice by Hinson, Jack A., Bucci, Thomas J., Irwin, Lisa K., Michael, Sherryll L., Mayeux, Philip R.

“…We recently reported that following a toxic dose of acetaminophen to mice, tyrosine nitration occurs in the protein of cells that become necrotic. Nitration of…”
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Acetaminophen-Induced Hepatotoxicity in Mice Lacking Inducible Nitric Oxide Synthase Activity by Michael, Sherryll L., Mayeux, Philip R., Bucci, Thomas J., Warbritton, Alan R., Irwin, Lisa K., Pumford, Neil R., Hinson, Jack A.

“…We recently reported that nitrotyrosine and acetaminophen (APAP)-cysteine protein adducts colocalize in the hepatic centrilobular cells following a toxic dose…”
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Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species by Michael, Sherryll L., Pumford, Neil R., Mayeux, Philip R., Niesman, Michael R., Hinson, Jack A.

“…Hepatotoxic doses of acetaminophen to mice produce not only acetaminophen‐protein adducts in the centrilobular cells of the liver, but nitrotyrosine‐protein…”
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Western Blot Analysis for Nitrotyrosine Protein Adducts in Livers of Saline-Treated and Acetaminophen-Treated Mice by Hinson, Jack A., Michael, Sherryll L., Ault, Subrena G., Pumford, Neil R.

“…The hepatic centrilobular necrosis produced by the analgesic/antipyretic acetaminophen correlates with metabolic activation of the drug leading to its covalent…”
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