Search Results - "Michael, P J"

Synergistic effects of common schizophrenia risk variants by Schrode, Nadine, Ho, Seok-Man, Yamamuro, Kazuhiko, Dobbyn, Amanda, Huckins, Laura, Matos, Marliette R., Cheng, Esther, Deans, P. J. Michael, Flaherty, Erin, Barretto, Natalie, Topol, Aaron, Alganem, Khaled, Abadali, Sonya, Gregory, James, Hoelzli, Emily, Phatnani, Hemali, Singh, Vineeta, Girish, Deeptha, Aronow, Bruce, Mccullumsmith, Robert, Hoffman, Gabriel E., Stahl, Eli A., Morishita, Hirofumi, Sklar, Pamela, Brennand, Kristen J.

“…The mechanisms by which common risk variants of small effect interact to contribute to complex genetic disorders are unclear. Here, we apply a genetic…”
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Analysis framework and experimental design for evaluating synergy-driving gene expression by Schrode, Nadine, Seah, Carina, Deans, P. J. Michael, Hoffman, Gabriel, Brennand, Kristen J.

“…The mechanisms by which genetic risk variants interact with each other, as well as environmental factors, to contribute to complex genetic disorders remain…”
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Of Mice and Mates: Automated Classification and Modelling of Mouse Behaviour in Groups Using a Single Model Across Cages by Camilleri, Michael P. J., Bains, Rasneer S., Williams, Christopher K. I.

“…Behavioural experiments often happen in specialised arenas, but this may confound the analysis. To address this issue, we provide tools to study mice in the…”
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Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer by Crowley, Michael J. P., Bhinder, Bhavneet, Markowitz, Geoffrey J., Martin, Mitchell, Verma, Akanksha, Sandoval, Tito A., Chae, Chang-Suk, Yomtoubian, Shira, Hu, Yang, Chopra, Sahil, Tavarez, Diamile A., Giovanelli, Paolo, Gao, Dingcheng, McGraw, Timothy E., Altorki, Nasser K., Elemento, Olivier, Cubillos-Ruiz, Juan R., Mittal, Vivek

“…IRE1α-XBP1 signaling is emerging as a central orchestrator of malignant progression and immunosuppression in various cancer types. Employing a computational…”
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Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve immunotherapy by Markowitz, Geoffrey J., Ban, Yi, Tavarez, Diamile A., Yoffe, Liron, Podaza, Enrique, He, Yongfeng, Martin, Mitchell T., Crowley, Michael J. P., Sandoval, Tito A., Gao, Dingcheng, Martin, M. Laura, Elemento, Olivier, Cubillos-Ruiz, Juan R., McGraw, Timothy E., Altorki, Nasser K., Mittal, Vivek

“…TCF1 high progenitor CD8 + T cells mediate the efficacy of immunotherapy; however, the mechanisms that govern their generation and maintenance are poorly…”
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Reconciling the Spatial Distribution of the Surface Temperature Trends in the Southeastern United States by Misra, V., Michael, J.-P., Boyles, R., Chassignet, E. P., Griffin, M., O’Brien, J. J.

“…This study attempts to explain the considerable spatial heterogeneity in the observed linear trends of monthly mean maximum and minimum temperatures (T maxandT…”
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Persistent animal identification leveraging non-visual markers by Camilleri, Michael P. J., Zhang, Li, Bains, Rasneer S., Zisserman, Andrew, Williams, Christopher K. I.

“…Our objective is to locate and provide a unique identifier for each mouse in a cluttered home-cage environment through time, as a precursor to automated…”
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Varied Diagnosis of the Observed Surface Temperature Trends in the Southeast United States by Misra, V., Michael, J.-P.

“…This paper diagnoses the temperature trends in maximum (T max) and minimum temperatures (T min) over a selection of 65 stations spread over the southeast…”
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Magmatic and amagmatic seafloor generation at the ultraslow-spreading Gakkel ridge, Arctic Ocean by Michael, P. J, Langmuir, C. H, Dick, H. J. B, Snow, J. E, Goldstein, S. L, Graham, D. W, Lehnert, K, Kurras, G, Jokat, W, Mühe, R, Edmonds, H. N

“…A high-resolution mapping and sampling study of the Gakkel ridge was accomplished during an international ice-breaker expedition to the high Arctic and North…”
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Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis by Poulos, Michael G., Ramalingam, Pradeep, Gutkin, Michael C., Kleppe, Maria, Ginsberg, Michael, Crowley, Michael J. P., Elemento, Olivier, Levine, Ross L., Rafii, Shahin, Kitajewski, Jan, Greenblatt, Matthew B., Shim, Jae-Hyuck, Butler, Jason M.

“…Haematopoietic stem cells (HSCs) reside in distinct niches within the bone marrow (BM) microenvironment, comprised of endothelial cells (ECs) and tightly…”
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Neuroligin-3 and neuroligin-4X form nanoscopic clusters and regulate growth cone organization and size by Gatford, Nicholas J F, Deans, P J Michael, Duarte, Rodrigo R R, Chennell, George, Sellers, Katherine J, Raval, Pooja, Srivastava, Deepak P

“…Abstract The cell-adhesion proteins neuroligin-3 and neuroligin-4X (NLGN3/4X) have well described roles in synapse formation. NLGN3/4X are also expressed…”
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Injuries and overuse syndromes in powerlifting by Siewe, J, Rudat, J, Röllinghoff, M, Schlegel, U J, Eysel, P, Michael, J W-P

“…Powerlifting is a discipline of competitive weightlifting. To date, no investigations have focused on pain encountered during routine training. The aim of the…”
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Development and Initial Validation of the Student Interest and Choice in STEM (SIC-STEM) Survey 2.0 Instrument for Assessment of the Social Cognitive Career Theory Constructs by Roller, Sarah A., Lampley, Sandra A., Dillihunt, Monica L., Benfield, Michael P. J., Gholston, Sampson E., Turner, Matthew W., Davis, Andrew M.

“…In response to a growing need for STEM professionals, this study reports the results of the initial validation of a refined survey instrument that purports to…”
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Understanding the Conceptions of Engineering in Early Elementary Students by Lampley, Sandra A., Dyess, Sarah Roller, Benfield, Michael P. J., Davis, Andrew M., Gholston, Sampson E., Dillihunt, Monica L., Turner, Matthew W.

“…There is a demand for more STEM professionals. Early elementary students’ conceptions about engineering can influence whether or not they explore STEM career…”
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Prostate-Specific Membrane Antigen Is a Potential Antiangiogenic Target in Adrenocortical Carcinoma by Crowley, Michael J. P, Scognamiglio, Theresa, Liu, Yi-Fang, Kleiman, David A, Beninato, Toni, Aronova, Anna, Liu, He, Jhanwar, Yuliya S, Molina, Ana, Tagawa, Scott T, Bander, Neil H, Zarnegar, Rasa, Elemento, Olivier, Fahey, Thomas J

“…Context: Adrenocortical carcinoma (ACC) is a rare tumor type with a poor prognosis and few therapeutic options. Objective: Assess prostate-specific membrane…”
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DNA methylation of IGF2DMR and H19 is associated with fetal and infant growth: the generation R study by Bouwland-Both, Marieke I, van Mil, Nina H, Stolk, Lisette, Eilers, Paul H C, Verbiest, Michael M P J, Heijmans, Bastiaan T, Tiemeier, Henning, Hofman, Albert, Steegers, Eric A P, Jaddoe, Vincent W V, Steegers-Theunissen, Régine P M

“…Changes in epigenetic programming of embryonic growth genes during pregnancy seem to affect fetal growth. Therefore, in a population-based prospective birth…”
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Silencing of UCHL1 by CpG Promoter Hyper-methylation is Associated with Metastatic Gastroenteropancreatic Well-Differentiated Neuroendocrine (Carcinoid) Tumors by Kleiman, David A., Beninato, Toni, Sultan, Samuel, Crowley, Michael J. P., Finnerty, Brendan, Kumar, Ritu, Panarelli, Nicole C., Liu, Yi-Fang, Lieberman, Michael D., Seandel, Marco, Evans, Todd, Elemento, Olivier, Zarnegar, Rasa, Fahey, Thomas J.

“…Background Well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare tumors with varying metastatic potential. The underlying…”
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Controlled Nucleation of Lipid Nanoparticles by Nguyen, Juliane, Walsh, Colin L., Motion, J. P. Michael, Perttu, Emily K., Szoka, Francis

“…ABSTRACT Purpose We describe a nucleation-based method which allows for the generation of monodisperse lipid nanoparticles over a range of diameters. Using a…”
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ICT for e-learning in three higher education institutions in Tanzania by Mahenge, Michael P J, Sanga, Camilius

“…The advancement in Information and Communication Technology (ICT) has brought new opportunities for learning. Tanzania is adopting the new technologies in…”
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Electron-Induced Dissociation of Singly Charged Organic Cations as a Tool for Structural Characterization of Pharmaceutical Type Molecules by Mosely, Jackie A, Smith, Michael J. P, Prakash, Aruna S, Sims, Martin, Bristow, Anthony W. T

“…Collision-induced dissociation (CID) and electron-induced dissociation (EID) have been investigated for a selection of small, singly charged organic molecules…”
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