Search Results - "Michael, Natalie"

New Horizons: Is Obesity a Disorder of Neurotransmission? by Caron, Alexandre, Jane Michael, Natalie

“…Obesity is a disease of the nervous system. While some will view this statement as provocative, others will take it as obvious. Whatever our side is, the…”
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Long Chain Fatty Acids Differentially Regulate Sub-populations of Arcuate POMC and NPY Neurons by Michael, Natalie J., Watt, Matthew J.

“…•LCFAs differentially affect POMC and NPY neuron activity.•Oleic and palmitic acids inhibit POMC neuron activity.•Oleic and palmitic acids excite NPY neuron…”
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Sex‐specific Consequences of Psychosocial Stress on Cardiorespiratory Control: a Comparison with Intermittent Hypoxia by Gagnon, Marianne, Fournier, Stéphanie, Marcouiller, François, Joseph, Vincent, Michael, Natalie J., Kinkead, Richard

“…Sleep apnea (SA) is a complex, multifactorial and a sex‐specific respiratory disorder; sexual dimorphism being present both in its prevalence and in the…”
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Coordination of metabolism, arousal, and reward by orexin/hypocretin neurons by Michael, Natalie J, Elmquist, Joel K

“…Orexin/hypocretin neurons located in the lateral hypothalamus play a critical role in the maintenance of arousal and contribute to the regulation of multiple…”
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Electrophysiological Comparison of Definitive Pro-opiomelanocortin Neurons in the Arcuate Nucleus and the Retrochiasmatic Area of Male and Female Mice by Srour, Nader, Lavoie, Olivier, Khouma, Axelle, Minbashi Moeini, Moein, Plamondon, Julie, Kinkead, Richard, Michael, Natalie J., Caron, Alexandre

“…[Display omitted] •80% of POMC neurons of the retrochiasmatic area (RCA) express the leptin receptor.•42% of POMC neurons of the arcuate nucleus (ARC) express…”
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Direct and indirect effects of liraglutide on hypothalamic POMC and NPY/AgRP neurons – Implications for energy balance and glucose control by He, Zhenyan, Gao, Yong, Lieu, Linh, Afrin, Sadia, Cao, Jianhong, Michael, Natalie J., Dong, Yanbin, Sun, Jia, Guo, Hongbo, Williams, Kevin W.

“…The long-acting glucagon-like peptide-1 receptor (GLP-1R) agonist, liraglutide, stimulates insulin secretion and efficiently suppresses food intake to reduce…”
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Insulin regulates POMC neuronal plasticity to control glucose metabolism by Dodd, Garron T, Michael, Natalie J, Lee-Young, Robert S, Mangiafico, Salvatore P, Pryor, Jack T, Munder, Astrid C, Simonds, Stephanie E, Brüning, Jens Claus, Zhang, Zhong-Yin, Cowley, Michael A, Andrikopoulos, Sofianos, Horvath, Tamas L, Spanswick, David, Tiganis, Tony

“…Hypothalamic neurons respond to nutritional cues by altering gene expression and neuronal excitability. The mechanisms that control such adaptive processes…”
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Electrophysiological Properties of Genetically Identified Histaminergic Neurons by Michael, Natalie J., Zigman, Jeffrey M., Williams, Kevin W., Elmquist, Joel K.

“…•Mouse histaminergic neurons display heterogeneity in their electrophysiological properties.•Electrophysiological properties of histaminergic neurons are…”
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A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding by Dodd, Garron T., Andrews, Zane B., Simonds, Stephanie E., Michael, Natalie J., DeVeer, Michael, Brüning, Jens C., Spanswick, David, Cowley, Michael A., Tiganis, Tony

“…Beige adipocytes can interconvert between white and brown-like states and switch between energy storage versus expenditure. Here we report that beige adipocyte…”
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Adipocyte Gs but not Gi signaling regulates whole-body glucose homeostasis by Caron, Alexandre, Reynolds, Ryan P., Castorena, Carlos M., Michael, Natalie J., Lee, Charlotte E., Lee, Syann, Berdeaux, Rebecca, Scherer, Philipp E., Elmquist, Joel K.

“…The sympathetic nervous system (SNS) is a key regulator of the metabolic and endocrine functions of adipose tissue. Increased SNS outflow promotes fat…”
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A Neural basis for Octanoic acid regulation of energy balance by Haynes, Vanessa R., Michael, Natalie J., van den Top, Marco, Zhao, Fei-Yue, Brown, Russell D., De Souza, David, Dodd, Garron T., Spanswick, David, Watt, Matthew J.

“…Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aimed to identify long- and medium-chain…”
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A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding by Dodd, Garron T., Andrews, Zane B., Simonds, Stephanie E., Michael, Natalie J., DeVeer, Michael, Brüning, Jens C., Spanswick, David, Cowley, Michael A., Tiganis, Tony

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Melanocortin regulation of histaminergic neurons via perifornical lateral hypothalamic melanocortin 4 receptors by Michael, Natalie J., Caron, Alexandre, Lee, Charlotte E., Castorena, Carlos M., Lee, Syann, Zigman, Jeffrey M., Williams, Kevin W., Elmquist, Joel K.

“…Histaminergic neurons of the tuberomammillary nucleus (TMN) are wake-promoting and contribute to the regulation of energy homeostasis. Evidence indicates that…”
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Histaminergic regulation of food intake by Khouma, Axelle, Moeini, Moein Minbashi, Plamondon, Julie, Richard, Denis, Caron, Alexandre, Michael, Natalie Jane

“…Histamine is a biogenic amine that acts as a neuromodulator within the brain. In the hypothalamus, histaminergic signaling contributes to the regulation of…”
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Effects of caffeine on alertness as measured by infrared reflectance oculography by Michael, Natalie, Johns, Murray, Owen, Caroline, Patterson, John

“…Rationale Caffeine is a well-known stimulant that can be used to increase alertness and performance especially in low arousal situations such as monotonous…”
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Mitochondrial uncoupling in the melanocortin system differentially regulates NPY and POMC neurons to promote weight-loss by Michael, Natalie Jane, Simonds, Stephanie Elise, van den Top, Marco, Cowley, Michael Alexander, Spanswick, David

“…The mitochondrial uncoupling agent 2,4-dinitrophenol (DNP), historically used as a treatment for obesity, is known to cross the blood-brain-barrier, but its…”
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A critical update on the leptin‐melanocortin system by Lavoie, Olivier, Michael, Natalie Jane, Caron, Alexandre

“…The discovery of leptin in 1994 was an “eureka moment” in the field of neurometabolism that provided new opportunities to better understand the central control…”
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Do POMC neurons have a sweet tooth for leptin? Special issue: Role of nutrients in nervous control of energy balance by Srour, Nader, Caron, Alexandre, Michael, Natalie Jane

“…Coordinated detection of changes in metabolic state by the nervous system is fundamental for survival. Hypothalamic pro-opiomelanocortin (POMC) neurons play a…”
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A critical update on the l eptin‐melanocortin system by Lavoie, Olivier, Michael, Natalie Jane, Caron, Alexandre

“…Abstract The discovery of leptin in 1994 was an “eureka moment” in the field of neurometabolism that provided new opportunities to better understand the…”
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Coordination of metabolism, arousal, and reward by orexin/hypocretin neurons by Michael, Natalie J, Elmquist, Joel K

“…Orexin/hypocretin neurons located in the lateral hypothalamus play a critical role in the maintenance of arousal and contribute to the regulation of multiple…”
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