Search Results - "Michael, K.P."

Vertical T cell immunodominance and epitope entropy determine HIV-1 escape by Liu, Michael K P, Hawkins, Natalie, Ritchie, Adam J, Ganusov, Vitaly V, Whale, Victoria, Brackenridge, Simon, Li, Hui, Pavlicek, Jeffrey W, Cai, Fangping, Rose-Abrahams, Melissa, Treurnicht, Florette, Hraber, Peter, Riou, Catherine, Gray, Clive, Ferrari, Guido, Tanner, Rachel, Ping, Li-Hua, Anderson, Jeffrey A, Swanstrom, Ronald, Cohen, Myron, Karim, Salim S Abdool, Haynes, Barton, Borrow, Persephone, Perelson, Alan S, Shaw, George M, Hahn, Beatrice H, Williamson, Carolyn, Korber, Bette T, Gao, Feng, Self, Steve, McMichael, Andrew, Goonetilleke, Nilu

“…HIV-1 accumulates mutations in and around reactive epitopes to escape recognition and killing by CD8+ T cells. Measurements of HIV-1 time to escape should…”
Get full text

Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection by Ferrari, Guido, Korber, Bette, Goonetilleke, Nilu, Liu, Michael K P, Turnbull, Emma L, Salazar-Gonzalez, Jesus F, Hawkins, Natalie, Self, Steve, Watson, Sydeaka, Betts, Michael R, Gay, Cynthia, McGhee, Kara, Pellegrino, Pierre, Williams, Ian, Tomaras, Georgia D, Haynes, Barton F, Gray, Clive M, Borrow, Persephone, Roederer, Mario, McMichael, Andrew J, Weinhold, Kent J

“…In the present study, we analyzed the functional profile of CD8+ T-cell responses directed against autologous transmitted/founder HIV-1 isolates during acute…”
Get full text

Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection by Kramer, Holger B, Lavender, Kerry J, Qin, Li, Stacey, Andrea R, Liu, Michael K P, di Gleria, Katalin, Simmons, Alison, Gasper-Smith, Nancy, Haynes, Barton F, McMichael, Andrew J, Borrow, Persephone, Kessler, Benedikt M

“…The earliest immune responses activated in acute human immunodeficiency virus type 1 infection (AHI) exert a critical influence on subsequent virus spread or…”
Get full text

The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection by Goonetilleke, Nilu, Liu, Michael K P, Salazar-Gonzalez, Jesus F, Ferrari, Guido, Giorgi, Elena, Ganusov, Vitaly V, Keele, Brandon F, Learn, Gerald H, Turnbull, Emma L, Salazar, Maria G, Weinhold, Kent J, Moore, Stephen, Letvin, Norman, Haynes, Barton F, Cohen, Myron S, Hraber, Peter, Bhattacharya, Tanmoy, Borrow, Persephone, Perelson, Alan S, Hahn, Beatrice H, Shaw, George M, Korber, Bette T, McMichael, Andrew J

“…Identification of the transmitted/founder virus makes possible, for the first time, a genome-wide analysis of host immune responses against the infecting HIV-1…”
Get full text

SARS-CoV-2 and HIV-1: Should HIV-1-Infected Individuals in Sub-Saharan Africa Be Considered a Priority Group for the COVID-19 Vaccines? by Mandala, Wilson Lewis, Liu, Michael K P

“…Since its emergence in 2019 SARS-CoV-2 has proven to have a higher level of morbidity and mortality compared to the other prevailing coronaviruses. Although…”
Get full text

Fitness Costs and Diversity of the Cytotoxic T Lymphocyte (CTL) Response Determine the Rate of CTL Escape during Acute and Chronic Phases of HIV Infection by GANUSOV, Vitaly V, GOONETILLEKE, Nilu, LIU, Michael K. P, FERRARI, Guido, SHAW, George M, MCMICHAEL, Andrew J, BORROW, Persephone, KORBER, Bette T, PERELSON, Alan S

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

An Early HIV Mutation within an HLA-B57-Restricted T Cell Epitope Abrogates Binding to the Killer Inhibitory Receptor 3DL1 by BRACKENRIDGE, Simon, EVANS, Edward J, TOEBES, Mireille, GOONETILLEKE, Nilu, LIU, Michael K. P, DI GLERIA, Kati, SCHUMACHER, Ton N, DAVIS, Simon J, MCMICHAEL, Andrew J, GILLESPIE, Geraldine M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Emergency Department Management of Heart Failure and COPD: A National Survey of Attitudes and Practice by Hale, Michael K P, Stiell, Ian G, Clement, Catherine M

“…The Ottawa Heart Failure Risk Scale (OHFRS) and the Ottawa COPD Risk Scale (OCRS) were developed in order to estimate medical risk and to help guide…”
Get more information

Application of a Dual Force Sensor System to Characterize the Intrinsic Operation of Horse Bridles and Bits by Cross, Graham H., Cheung, Michael K.P., Honey, Thomas J., Pau, Michael K., Senior, Kara-Jane

“…An equine bridle tension system, with electronic force gauges in both the line of the reins and that of the cheekpiece (CP) on one side of the horse, is used…”
Get full text

Distinct kinetics of Gag-specific CD4+ and CD8+ T cell responses during acute HIV-1 infection by Riou, Catherine, Ganusov, Vitaly V, Campion, Suzanne, Mlotshwa, Mandla, Liu, Michael K P, Whale, Victoria E, Goonetilleke, Nilu, Borrow, Persephone, Ferrari, Guido, Betts, Michael R, Haynes, Barton F, McMichael, Andrew J, Gray, Clive M

“…HIV infection is characterized by a gradual deterioration of immune function, mainly in the CD4 compartment. To better understand the dynamics of HIV-specific…”
Get full text

Increased memory differentiation is associated with decreased polyfunctionality for HIV but not for cytomegalovirus-specific CD8+ T cells by Riou, Catherine, Treurnicht, Florette, Abrahams, Melissa-Rose, Mlisana, Koleka, Liu, Michael K P, Goonetilleke, Nilu, Koup, Richard, Roederer, Mario, Abdool Karim, Salim, de Bruyn, Guy, Williamson, Carolyn, Gray, Clive M, Burgers, Wendy A

“…The generation of polyfunctional CD8(+) T cells, in response to vaccination or natural infection, has been associated with improved protective immunity…”
Get full text

A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies by Liu, Donglai, Wang, Chu, Hora, Bhavna, Zuo, Tao, Goonetilleke, Nilu, Liu, Michael K P, Berrong, Mark, Ferrari, Guido, McMichael, Andrew J, Bhattacharya, Tanmoy, Perelson, Alan S, Gao, Feng

“…Mutations rapidly accumulate in the HIV-1 genome after infection. Some of those mutations are selected by host immune responses and often cause viral fitness…”
Get full text

Reversion and T cell escape mutations compensate the fitness loss of a CD8+ T cell escape mutant in their cognate transmitted/founder virus by Song, Hongshuo, Hora, Bhavna, Bhattacharya, Tanmoy, Goonetilleke, Nilu, Liu, Michael K P, Wiehe, Kevin, Li, Hui, Iyer, Shilpa S, McMichael, Andrew J, Perelson, Alan S, Gao, Feng

“…Immune escape mutations that revert back to the consensus sequence frequently occur in newly HIV-1-infected individuals and have been thought to render the…”
Get full text

Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome by Song, Hongshuo, Pavlicek, Jeffrey W, Cai, Fangping, Bhattacharya, Tanmoy, Li, Hui, Iyer, Shilpa S, Bar, Katharine J, Decker, Julie M, Goonetilleke, Nilu, Liu, Michael K P, Berg, Anna, Hora, Bhavna, Drinker, Mark S, Eudailey, Josh, Pickeral, Joy, Moody, M Anthony, Ferrari, Guido, McMichael, Andrew, Perelson, Alan S, Shaw, George M, Hahn, Beatrice H, Haynes, Barton F, Gao, Feng

“…A modest change in HIV-1 fitness can have a significant impact on viral quasispecies evolution and viral pathogenesis, transmission and disease progression. To…”
Get full text

Differences in HIV-Specific T Cell Responses between HIV-Exposed and -Unexposed HIV-Seronegative Individuals by RITCHIE, Adam J, CAMPION, Suzanne L, LEGG, Kenneth, COHEN, Myron S, DELWART, Eric L, HAYNES, Barton F, FIDLER, Sarah, MCMICHAEL, Andrew J, GOONETILLEKE, Nilu, KOPYCINSKI, Jakub, MOODIE, Zoe, WANG, Z. Maggie, PANDYA, Kruti, MOORE, Stephen, LIU, Michael K. P, BRACKENRIDGE, Simon, KULDANEK, Kristin

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Increased memory differentiation is associated with decreased polyfunctionality for HIV but not for CMV-specific CD8+ T cells by Riou, Catherine, Treurnicht, Florette, Abrahams, Melissa-Rose, Mlisana, Koleka, Liu, Michael K.P., Goonetilleke, Nilu, Koup, Richard, Roederer, Mario, Karim, Salim Abdool, de Bruyn, Guy, Williamson, Carolyn, Gray, Clive M., Burgers, Wendy A.

“…The generation of polyfunctional CD8+ T cells, in response to vaccination or natural infection, has been associated with improved protective immunity. However,…”
Get full text

Integration of CD28 and CTLA‐4 function results in differential responses of T cells to CD80 and CD86 by Manzotti, Claire N., Liu, Michael K. P., Burke, Fiona, Dussably, Laure, Zheng, Yong, Sansom, David M.

“…CD80 and CD86 have the capacity to either stimulate or inhibit T cell responses through their receptors CD28 and cytotoxic T lymphocyte‐associated antigen 4…”
Get full text

Exocytosis of CTLA-4 Is Dependent on Phospholipase D and ADP Ribosylation Factor-1 and Stimulated during Activation of Regulatory T Cells by Mead, Karen I, Zheng, Yong, Manzotti, Claire N, Perry, Laura C. A, Liu, Michael K. P, Burke, Fiona, Powner, Dale J, Wakelam, Michael J. O, Sansom, David M

“…CTLA-4 is an essential protein in the regulation of T cell responses that interacts with two ligands found on the surface of APCs (CD80 and CD86). CTLA-4 is…”
Get full text

Bonamia exitiosa epizootic in Ostrea chilensis from Foveaux Strait, southern New Zealand between 1986 and 1992 by Cranfield, H.J., Dunn, A., Doonan, I.J., Michael, K.P.

“…Disease caused by the haplosporidian parasite, Bonamia exitiosa, swept through the dredge oyster (Ostrea chilensis) population of Foveaux Strait between 1986…”
Get full text

Diagnostic accuracy and clinical utility of a simplified low cost method of counting CD4 cells with flow cytometry in Malawi: diagnostic accuracy study by MacLennan, Calman A, Liu, Michael K P, White, Sarah A, van Oosterhout, Joep J G, Simukonda, Felanji, Bwanali, Joseph, Moore, Michael J, Zijlstra, Eduard E, Drayson, Mark T, Molyneux, Malcolm E

“…Objectives To assess the diagnostic accuracy and clinical utility of a simplified low cost method for measuring absolute and percentage CD4 counts with flow…”
Get full text